Replication of association of CHRNA4 rare variants with sporadic amyotrophic lateral sclerosis: The Italian multicentre study

Mario Sabatelli, Giuseppe Marangi, Marcella Zollino, Serena Lattante, Amelia Conte, Marco Luigetti, Alessandra Del Grande, Paolo Zeppilli, Alessandra Bizzarro, Ettore Domenico Capoluongo, Giovanni Neri, Paolo Maria Rossini, Adriano Chiò, Massimo Corbo, Fabio Giannini, Jessica Mandrioli, Gabriele Mora, Andrea Calvo, Gabriella Restagno, Christian LunettaSilvana Penco, Stefania Battistini

Risultato della ricerca: Contributo in rivistaArticolo in rivista

7 Citazioni (Scopus)

Abstract

Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels widely expressed throughout the mammalian brain, including bulbar and spinal motor neurons. They are involved in neuroprotection and in control of release of many neurotransmitters, including glutamate. Previous data raised the hypothesis that rare variants in the region coding the intracellular loop subunits of nAChRs might represent one of several genetic risk factors for SALS. The aim of present study was to replicate the study in an independent cohort of ALS patients. We analysed 718 sporadic ALS patients from five Italian ALS centres and 1300 ethnically matched controls. We focused primarily on CHRNA4, encoding α4 subunit, since most mutations were previously detected in this gene. We observed a significant association between CHRNA4 mutations and ALS (OR 2.91; 95% CI 1.4080-6.0453; p = 0.0056). Most mutations detected in patients were not present in the dbSNP134 and in 3500 ethnically matched control chromosomes and affected evolutionary conserved amino acid residues. In conclusion, the present data confirm that CHRNA4 variants are overrepresented in SALS strengthening the hypothesis can they act as predisposing genetic factors for SALS.
Lingua originaleEnglish
pagine (da-a)580-584
Numero di pagine5
RivistaAmyotrophic Lateral Sclerosis
Volume13
DOI
Stato di pubblicazionePubblicato - 2012

Keywords

  • ALS
  • nAchR

Fingerprint

Entra nei temi di ricerca di 'Replication of association of CHRNA4 rare variants with sporadic amyotrophic lateral sclerosis: The Italian multicentre study'. Insieme formano una fingerprint unica.

Cita questo