Renal toxicity and chemotherapy in children with cancer

Antonio Ruggiero, Pietro Ferrara, Giorgio Attina', Daniela Rizzo, Riccardo Riccardi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

28 Citazioni (Scopus)

Abstract

The clinical use of antineoplastic drugs can be limited by different drug-induced toxicities. Of these, renal dysfunction may be one of the most troublesome in that it can be cumulative and in general is only partially reversible with the discontinuation of the treatment. Renal toxicity may be manifested as a reduction of the glomerular filtration rate, electrolyte imbalances, or acute renal failure. Careful assessment of renal function has to be performed taking into account that the impairment of renal function is initially silent and only later may be clinically dramatic. When clinically indicated, the reduction or, in cases of severe nephrotoxicity, the suspension of chemotherapy should be considered to avoid the progressive deterioration of the compromised glomerular and/or tubular function.
Lingua originaleEnglish
pagine (da-a)2605-2614
Numero di pagine10
RivistaBRITISH JOURNAL OF CLINICAL PHARMACOLOGY
Volume83
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • Chemotherapy
  • Children
  • Nephrotoxicity
  • Pharmacology
  • Pharmacology (medical)

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