TY - JOUR
T1 - Reliability of the Hammersmith functional motor scale for spinal muscular atrophy in a multicentric study
AU - Mercuri, Eugenio Maria
AU - Messina, S.
AU - Battini, R.
AU - Berardinelli, A.
AU - Boffi, P.
AU - Bono, R.
AU - Bruno, C.
AU - Carboni, N.
AU - Cini, C.
AU - Colitto, F.
AU - D'Amico, A.
AU - Minetti, C.
AU - Mirabella, Massimiliano
AU - Mongini, T.
AU - Morandi, L.
AU - Dlamini, N.
AU - Orcesi, S.
AU - Pelliccioni, M.
AU - Pane, Marika
AU - Pini, A.
AU - Swan, A. V.
AU - Villanova, M.
AU - Vita, G.
AU - Main, M.
AU - Muntoni, F.
AU - Bertini, E.
PY - 2006
Y1 - 2006
N2 - The aim of this study was to validate the Hammersmith functional motor scale for children with spinal muscular atrophy in a large cohort of 90 non-ambulant children with spinal muscular atrophy type 2 or 3. All had a baseline assessment (T0) and were reassessed either at 3 months (T1) (n=66) or at 6 months (T2) (n=24). Inter-observer reliability, tested on 13 children among 3 examiners, was >95%. Of the 66 children examined after 3 months 4 had adverse effects in between assessments and were excluded from the analysis. Forty-two (68%) of the remaining 62 reassessed had no variation in scores between T0 and T1 and 13 (21%) were within ±1 point. 9 (37.5%) of the 24 children reassessed after 6 months had no variation in scores between T0 and T2 and another 9 (37.5%) had variations within ±1 point. Our study confirms previous observations of the reliability of the scale and helps to establish a baseline for assessing changes of functional ability over 3 and 6 month intervals. This information can be valuable in view of therapeutic trials. © 2005 Elsevier B.V. All rights reserved.
AB - The aim of this study was to validate the Hammersmith functional motor scale for children with spinal muscular atrophy in a large cohort of 90 non-ambulant children with spinal muscular atrophy type 2 or 3. All had a baseline assessment (T0) and were reassessed either at 3 months (T1) (n=66) or at 6 months (T2) (n=24). Inter-observer reliability, tested on 13 children among 3 examiners, was >95%. Of the 66 children examined after 3 months 4 had adverse effects in between assessments and were excluded from the analysis. Forty-two (68%) of the remaining 62 reassessed had no variation in scores between T0 and T1 and 13 (21%) were within ±1 point. 9 (37.5%) of the 24 children reassessed after 6 months had no variation in scores between T0 and T2 and another 9 (37.5%) had variations within ±1 point. Our study confirms previous observations of the reliability of the scale and helps to establish a baseline for assessing changes of functional ability over 3 and 6 month intervals. This information can be valuable in view of therapeutic trials. © 2005 Elsevier B.V. All rights reserved.
KW - Clinical trial
KW - Functional abilities
KW - Hammersmith functional motor scale
KW - Reliability
KW - SMA
KW - Validation
KW - Clinical trial
KW - Functional abilities
KW - Hammersmith functional motor scale
KW - Reliability
KW - SMA
KW - Validation
UR - https://publicatt.unicatt.it/handle/10807/260321
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=31944440025&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=31944440025&origin=inward
U2 - 10.1016/j.nmd.2005.11.010
DO - 10.1016/j.nmd.2005.11.010
M3 - Article
SN - 0960-8966
VL - 16
SP - 93
EP - 98
JO - Neuromuscular Disorders
JF - Neuromuscular Disorders
IS - 2
ER -