Relative risk of plaque erosion among different age and sex groups in patients with acute coronary syndrome

Filippo Crea, Giampaolo Niccoli, Michele Russo, Hyung Oh Kim, Chong Jin Kim, Weon Kim, Jin-Man Cho, Tsunenari Soeda, Masamichi Takano, Bryan P Yan, Rocco Vergallo, Yoshiyasu Minami, Takumi Higuma, Shigeki Kimura, Niklas Frederik Boeder, Holger Nef, Tom Adriaenssens, Osamu Kurihara, Vikas Thondapu, Erika YamamotoTomoyo Sugiyama, Hang Lee, Tsunekazu Kakuta, Taishi Yonetsu, Ik-Kyung Jang

Risultato della ricerca: Contributo in rivistaArticolo in rivista

3 Citazioni (Scopus)

Abstract

ostmortem studies reported plaque erosion is frequent in young women. Recent in vivo studies failed to show age and sex differences in the plaque erosion prevalence. The aim of this study was to investigate the prevalence of plaque erosion by age and sex among acute coronary syndromes (ACS) patients. From 1699 ACS patients, 1083 with plaque erosion or rupture were analyzed. Patients were categorized as 5 age groups (≤ 50, 51-60, 61-70, 71-80, ≥ 81 years). Overall prevalence of plaque erosion was similar between males and females (p = 0.831). Males age ≤ 50 had higher (p = 0.018) and age 71-80 had lower (p = 0.006) prevalence of plaque erosion. Females age 61-70 had higher (p = 0.021) and age 71-80 had lower (p = 0.045) prevalence of plaque erosion. In advanced age groups (≥ 71 years), rupture was the dominant etiology in both sexes. In multivariate analysis of males, age ≤ 50 demonstrated a trend to increase (OR 1.418, 95% CI 0.961-2.093, p = 0.078) the erosion risk. Females age ≤ 70 independently increased (OR 2.138, 95% CI 1.249-3.661, p = 0.006) the risk for erosion. The prevalence of plaque erosion was similar between males and females. Plaque erosion risk was increased in the males age ≤ 50 and in the females age ≤ 70 among ACS patients.
Lingua originaleEnglish
pagine (da-a)352-359
Numero di pagine8
RivistaJOURNAL OF THROMBOSIS AND THROMBOLYSIS
Volume49
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • Acute coronary syndrome
  • Aging
  • Plaque erosion
  • Sex

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