TY - JOUR
T1 - Relapsing-remitting autoimmune agrypnia
AU - Batocchi, Anna Paola
AU - Della Marca, Giacomo
AU - Mirabella, Massimiliano
AU - Caggiula, Marcella
AU - Frisullo, Giovanni
AU - Mennuni, Gioacchino Francesco
AU - Tonali, Pietro Attilio
PY - 2001
Y1 - 2001
N2 - A woman affected by multiple cranial nerve palsy developed several episodes of total insomnia and respiratory crises resulting from central breathing depression associated with dysautonomic symptoms. Oligoclonal IgG bands were present in her cerebrospinal fluid, and immunohistochemistry showed increased binding of serum and cerebrospinal fluid on gamma-aminobutyric acid-ergic, synapse-rich neuronal cells. Immunosuppressive treatment and plasma exchange were followed by clinical improvement, with restoration of sleep architecture and disappearance of respiratory crises, suggesting autoimmune pathogenesis of the syndrome.
AB - A woman affected by multiple cranial nerve palsy developed several episodes of total insomnia and respiratory crises resulting from central breathing depression associated with dysautonomic symptoms. Oligoclonal IgG bands were present in her cerebrospinal fluid, and immunohistochemistry showed increased binding of serum and cerebrospinal fluid on gamma-aminobutyric acid-ergic, synapse-rich neuronal cells. Immunosuppressive treatment and plasma exchange were followed by clinical improvement, with restoration of sleep architecture and disappearance of respiratory crises, suggesting autoimmune pathogenesis of the syndrome.
KW - Autoimmune Diseases
KW - Autonomic Nervous System Diseases
KW - Cranial Nerve Diseases
KW - Electroencephalography
KW - Immunosuppressive Agents
KW - Plasma Exchange
KW - Polysomnography
KW - Respiratory Insufficiency
KW - Sleep Initiation and Maintenance Disorders
KW - Syndrome
KW - Voice Disorders
KW - Autoimmune Diseases
KW - Autonomic Nervous System Diseases
KW - Cranial Nerve Diseases
KW - Electroencephalography
KW - Immunosuppressive Agents
KW - Plasma Exchange
KW - Polysomnography
KW - Respiratory Insufficiency
KW - Sleep Initiation and Maintenance Disorders
KW - Syndrome
KW - Voice Disorders
UR - http://hdl.handle.net/10807/19977
U2 - 10.1002/ana.1261
DO - 10.1002/ana.1261
M3 - Article
SN - 0364-5134
VL - 50
SP - 668
EP - 671
JO - Annals of Neurology
JF - Annals of Neurology
ER -