Regulatory T-cell number is increased in chronic lymphocytic leukemia patients and correlates with progressive disease

Luca Laurenti, Laura De Padua, Michela Tarnani, G D'Arena, Mm Minervini, S Deaglio, L Bonello, L De Martino, L Savino, V De Feo, N. Cascavilla

Risultato della ricerca: Contributo in rivistaArticolo in rivista

101 Citazioni (Scopus)

Abstract

Regulatory T-cells (Treg) actively maintain immunological self-tolerance and play a significant role in the progression of cancer. Treg cell numbers have been evaluated in 80 patients with previously untreated chronic lymphocytic leukemia (CLL) and in 40 normal healthy volunteers. Treg cells are higher in CLL patients than in controls and correlate with disease status (more advanced clinical stage, peripheral blood B-cell lymphocytosis, absolute CD38+ B-cell number, and more elevated LDH levels). No correlation was found with ZAP-70 expression, IgVH mutational status and cytogenetic abnormalities. This data shows that Treg cell number is abnormal in CLL patients.
Lingua originaleEnglish
pagine (da-a)363-368
Numero di pagine6
RivistaLeukemia Research
Volume35
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, CD38
  • B-Lymphocytes
  • Case-Control Studies
  • Chromosome Aberrations
  • Disease Progression
  • Female
  • Humans
  • Immunoglobulin Heavy Chains
  • Immunoglobulin Variable Region
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Male
  • Middle Aged
  • Mutation
  • Prognosis
  • Survival Rate
  • T-Lymphocytes, Regulatory
  • Tumor Markers, Biological
  • ZAP-70 Protein-Tyrosine Kinase

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