Regulatory T-cell number is increased in chronic lymphocytic leukemia patients and correlates with progressive disease

G D'Arena; Luca Laurenti; Mm Minervini; S Deaglio; L Bonello; L De Martino; Laura De Padua; L Savino; Michela Tarnani; V De Feo; N. Cascavilla

doi:10.1016/j.leukres.2010.08.010

Regulatory T-cell number is increased in chronic lymphocytic leukemia patients and correlates with progressive disease

G D'Arena, Luca Laurenti, Mm Minervini, S Deaglio, L Bonello, L De Martino, Laura De Padua, L Savino, Michela Tarnani, V De Feo, N. Cascavilla

Risultato della ricerca: Contributo in rivista › Articolo in rivista

101 Citazioni (Scopus)

Abstract

Regulatory T-cells (Treg) actively maintain immunological self-tolerance and play a significant role in the progression of cancer. Treg cell numbers have been evaluated in 80 patients with previously untreated chronic lymphocytic leukemia (CLL) and in 40 normal healthy volunteers. Treg cells are higher in CLL patients than in controls and correlate with disease status (more advanced clinical stage, peripheral blood B-cell lymphocytosis, absolute CD38+ B-cell number, and more elevated LDH levels). No correlation was found with ZAP-70 expression, IgVH mutational status and cytogenetic abnormalities. This data shows that Treg cell number is abnormal in CLL patients.

Lingua originale	English
pagine (da-a)	363-368
Numero di pagine	6
Rivista	Leukemia Research
Volume	35
DOI	https://doi.org/10.1016/j.leukres.2010.08.010
Stato di pubblicazione	Pubblicato - 2011

Keywords

Adult
Aged
Aged, 80 and over
Antigens, CD38
B-Lymphocytes
Case-Control Studies
Chromosome Aberrations
Disease Progression
Female
Humans
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region
Leukemia, Lymphocytic, Chronic, B-Cell
Male
Middle Aged
Mutation
Prognosis
Survival Rate
T-Lymphocytes, Regulatory
Tumor Markers, Biological
ZAP-70 Protein-Tyrosine Kinase

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10.1016/j.leukres.2010.08.010

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title = "Regulatory T-cell number is increased in chronic lymphocytic leukemia patients and correlates with progressive disease",

abstract = "Regulatory T-cells (Treg) actively maintain immunological self-tolerance and play a significant role in the progression of cancer. Treg cell numbers have been evaluated in 80 patients with previously untreated chronic lymphocytic leukemia (CLL) and in 40 normal healthy volunteers. Treg cells are higher in CLL patients than in controls and correlate with disease status (more advanced clinical stage, peripheral blood B-cell lymphocytosis, absolute CD38+ B-cell number, and more elevated LDH levels). No correlation was found with ZAP-70 expression, IgVH mutational status and cytogenetic abnormalities. This data shows that Treg cell number is abnormal in CLL patients.",

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author = "G D'Arena and Luca Laurenti and Mm Minervini and S Deaglio and L Bonello and {De Martino}, L and {De Padua}, Laura and L Savino and Michela Tarnani and {De Feo}, V and N. Cascavilla",

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doi = "10.1016/j.leukres.2010.08.010",

language = "English",

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pages = "363--368",

journal = "Leukemia Research",

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AU - D'Arena, G

AU - Laurenti, Luca

AU - Minervini, Mm

AU - Deaglio, S

AU - Bonello, L

AU - De Martino, L

AU - De Padua, Laura

AU - Savino, L

AU - Tarnani, Michela

AU - De Feo, V

AU - Cascavilla, N.

PY - 2011

Y1 - 2011

N2 - Regulatory T-cells (Treg) actively maintain immunological self-tolerance and play a significant role in the progression of cancer. Treg cell numbers have been evaluated in 80 patients with previously untreated chronic lymphocytic leukemia (CLL) and in 40 normal healthy volunteers. Treg cells are higher in CLL patients than in controls and correlate with disease status (more advanced clinical stage, peripheral blood B-cell lymphocytosis, absolute CD38+ B-cell number, and more elevated LDH levels). No correlation was found with ZAP-70 expression, IgVH mutational status and cytogenetic abnormalities. This data shows that Treg cell number is abnormal in CLL patients.

AB - Regulatory T-cells (Treg) actively maintain immunological self-tolerance and play a significant role in the progression of cancer. Treg cell numbers have been evaluated in 80 patients with previously untreated chronic lymphocytic leukemia (CLL) and in 40 normal healthy volunteers. Treg cells are higher in CLL patients than in controls and correlate with disease status (more advanced clinical stage, peripheral blood B-cell lymphocytosis, absolute CD38+ B-cell number, and more elevated LDH levels). No correlation was found with ZAP-70 expression, IgVH mutational status and cytogenetic abnormalities. This data shows that Treg cell number is abnormal in CLL patients.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Antigens, CD38

KW - B-Lymphocytes

KW - Case-Control Studies

KW - Chromosome Aberrations

KW - Disease Progression

KW - Female

KW - Humans

KW - Immunoglobulin Heavy Chains

KW - Immunoglobulin Variable Region

KW - Leukemia, Lymphocytic, Chronic, B-Cell

KW - Male

KW - Middle Aged

KW - Mutation

KW - Prognosis

KW - Survival Rate

KW - T-Lymphocytes, Regulatory

KW - Tumor Markers, Biological

KW - ZAP-70 Protein-Tyrosine Kinase

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KW - Aged

KW - Aged, 80 and over

KW - Antigens, CD38

KW - B-Lymphocytes

KW - Case-Control Studies

KW - Chromosome Aberrations

KW - Disease Progression

KW - Female

KW - Humans

KW - Immunoglobulin Heavy Chains

KW - Immunoglobulin Variable Region

KW - Leukemia, Lymphocytic, Chronic, B-Cell

KW - Male

KW - Middle Aged

KW - Mutation

KW - Prognosis

KW - Survival Rate

KW - T-Lymphocytes, Regulatory

KW - Tumor Markers, Biological

KW - ZAP-70 Protein-Tyrosine Kinase

UR - http://hdl.handle.net/10807/5041

U2 - 10.1016/j.leukres.2010.08.010

DO - 10.1016/j.leukres.2010.08.010

M3 - Article

SN - 0145-2126

VL - 35

SP - 363

EP - 368

JO - Leukemia Research

JF - Leukemia Research

ER -

Regulatory T-cell number is increased in chronic lymphocytic leukemia patients and correlates with progressive disease

Abstract

Keywords

OSS delle Nazioni Unite

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