Reelin is transiently expressed in the peripheral nerve during development and is upregulated following nerve crush

Anna D'Altocolle, Aurora Del Fa' Gangitano, Carlo Gangitano, Roger Panteri, J. Mey, N. Zhelyaznik, C Marino, F. Lorenzetto, M. Buffelli, F. Keller

Risultato della ricerca: Contributo in rivistaArticolo in rivista

27 Citazioni (Scopus)

Abstract

Reelin is an extracellular matrix protein which is critical for the positioning of migrating post-mitotic neurons and the laminar organization of several brain structures during development. We investigated the expression and localization of Reelin in the rodent peripheral nerve during postnatal development and following crush injury in the adult stage. As shown with Western blotting, immunocytochemistry and RT-PCR, Schwann cells in the developing peripheral nerve and in primary cultures from neonatal nerves produce and secrete Reelin. While Reelin levels are downregulated in adult stages, they are again induced following sciatic nerve injury. A morphometric analysis of sciatic nerve sections of reeler mice suggests that Reelin is not essential for axonal ensheathment by Schwann cells, however, it influences the caliber of myelinated axons and the absolute number of fibers per unit area. This indicates that Reelin may play a role in peripheral nervous system development and repair by regulating Schwann cell–axon interactions.
Lingua originaleEnglish
pagine (da-a)133-142
Numero di pagine10
RivistaMolecular and Cellular Neurosciences
Stato di pubblicazionePubblicato - 2006

Keywords

  • development
  • peripheral nerve
  • reelin

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