Reduced intensity conditioning in unrelated donor transplantation for refractory cytopenia in childhood

B. Strahm, Franco Locatelli, P. Bader, K. Ehlert, B. Kremens, F. Zintl, M. Führer, D. Stachel, K. W. Sykora, P. Sedlacek, I. Baumann, C. M. Niemeyer

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Myelodysplastic syndromes (MDS) are a heterogenous group of acquired hematopoietic stem cell disorders. Refractory cytopenia ( RC) is the most common subtype of childhood MDS and hematopoietic stem cell transplantation (HSCT) is the only curative treatment. HSCT following a myeloablative preparative regimen is associated with a low probability of relapse and considerable transplant-related mortality. In the present European Working Groups of MDS pilot study, we investigated whether a reduced intensity conditioning regimen (RIC) is able to offer reduced toxicity without increased rates of graft failure or relapse. Nineteen children with RC were transplanted from an unrelated donor following RIC consisting of fludarabine, thiotepa and anti-thymocyte globulin. Three patients experienced graft failure. Neutrophil and platelet engraftment occurred at a median time of 23 and 30 days, respectively. Cumulative incidence of grade II-IV and grade III and IV acute graft-versus-host disease (GVHD) was 0.48 and 0.13, respectively; three patients developed extensive chronic GVHD. Although infections were the predominant complications, only one patient with extensive chronic GVHD died from infectious complications. Overall and event-free survival at 3 years were 0.84 and 0.74, respectively. In conclusion, our results were comparable to those of patients treated with myeloablative HSCT. Long-term follow-up is needed to demonstrate the expected reduction in long-term sequelae.
Lingua originaleEnglish
pagine (da-a)329-333
Numero di pagine5
RivistaBone Marrow Transplantation
Volume40
DOI
Stato di pubblicazionePubblicato - 2007

Keywords

  • refractory cytopenia
  • reduced intensity conditioning regimen
  • children
  • transplant-related complications
  • hematopoietic stem cell transplantation

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