Reduced fronto-temporal connectivity is associated with frontal gray matter density reduction and neuropsychological deficit in schizophrenia.

Ilaria Spoletini, Margherita Di Paola, Giovanni Martinotti, Pietro Bria, Gianfranco Spalletta, A Cherubini, G Banfi, N Rusch, Ia Rubino, A Siracusano, C Caltagirone

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

54 Citazioni (Scopus)

Abstract

A "disconnectivity model" of schizophrenia has been proposed, but it is still unclear if white mar abnormalities are associated with gray matter changes and if they may be the anatomic substrate of cognitive impairment, which is a core symptom of the disorder. The first objective was to detect if white matter microstructure alterations in schizophrenia are associated with or independent of gray matter change, using an optimized method for white matter (Tract-Based Spatial Statistics) and gray matter analyses (whole-brain voxel-wise approach). The second objective was to identify the neuropsychological correlates of white matter abnormalities in the schizophrenic group, using a comprehensive neuropsychological battery.
Lingua originaleEnglish
pagine (da-a)57-68
Numero di pagine12
RivistaSchizophrenia Research
Volume108
DOI
Stato di pubblicazionePubblicato - 2009

Keywords

  • Schizophrenia

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