TY - JOUR
T1 - Reduced fronto-temporal
connectivity is associated with frontal gray matter density reduction and
neuropsychological deficit in schizophrenia.
AU - Spoletini, Ilaria
AU - Cherubini, A
AU - Di Paola, Margherita
AU - Banfi, G
AU - Rusch, N
AU - Martinotti, Giovanni
AU - Bria, Pietro
AU - Rubino, Ia
AU - Siracusano, A
AU - Caltagirone, C
AU - Spalletta, Gianfranco
PY - 2009
Y1 - 2009
N2 - A "disconnectivity model" of schizophrenia has been proposed, but it is still unclear if white mar abnormalities are associated with gray matter changes and if they may be the anatomic substrate of cognitive impairment, which is a core symptom of the disorder. The first objective was to detect if white matter microstructure alterations in schizophrenia are associated with or independent of gray matter change, using an optimized method for white matter (Tract-Based Spatial Statistics) and gray matter analyses (whole-brain voxel-wise approach). The second objective was to identify the neuropsychological correlates of white matter abnormalities in the schizophrenic group, using a comprehensive neuropsychological battery.
AB - A "disconnectivity model" of schizophrenia has been proposed, but it is still unclear if white mar abnormalities are associated with gray matter changes and if they may be the anatomic substrate of cognitive impairment, which is a core symptom of the disorder. The first objective was to detect if white matter microstructure alterations in schizophrenia are associated with or independent of gray matter change, using an optimized method for white matter (Tract-Based Spatial Statistics) and gray matter analyses (whole-brain voxel-wise approach). The second objective was to identify the neuropsychological correlates of white matter abnormalities in the schizophrenic group, using a comprehensive neuropsychological battery.
KW - Schizophrenia
KW - Schizophrenia
UR - http://hdl.handle.net/10807/41642
U2 - 10.1016/j.schres.2008.11.011
DO - 10.1016/j.schres.2008.11.011
M3 - Article
SN - 0920-9964
VL - 108
SP - 57
EP - 68
JO - Schizophrenia Research
JF - Schizophrenia Research
ER -