Reduced fronto-temporal
connectivity is associated with frontal gray matter density reduction and
neuropsychological deficit in schizophrenia.

Ilaria Spoletini; A Cherubini; Margherita Di Paola; G Banfi; N Rusch; Giovanni Martinotti; Pietro Bria; Ia Rubino; A Siracusano; C Caltagirone; Gianfranco Spalletta

doi:10.1016/j.schres.2008.11.011

Reduced fronto-temporal connectivity is associated with frontal gray matter density reduction and neuropsychological deficit in schizophrenia.

Ilaria Spoletini, A Cherubini, Margherita Di Paola, G Banfi, N Rusch, Giovanni Martinotti, Pietro Bria, Ia Rubino, A Siracusano, C Caltagirone, Gianfranco Spalletta

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

54 Citazioni (Scopus)

Abstract

A "disconnectivity model" of schizophrenia has been proposed, but it is still unclear if white mar abnormalities are associated with gray matter changes and if they may be the anatomic substrate of cognitive impairment, which is a core symptom of the disorder. The first objective was to detect if white matter microstructure alterations in schizophrenia are associated with or independent of gray matter change, using an optimized method for white matter (Tract-Based Spatial Statistics) and gray matter analyses (whole-brain voxel-wise approach). The second objective was to identify the neuropsychological correlates of white matter abnormalities in the schizophrenic group, using a comprehensive neuropsychological battery.

Lingua originale	English
pagine (da-a)	57-68
Numero di pagine	12
Rivista	Schizophrenia Research
Volume	108
DOI	https://doi.org/10.1016/j.schres.2008.11.011
Stato di pubblicazione	Pubblicato - 2009
Pubblicato esternamente	Sì

Keywords

Schizophrenia

Accesso al documento

10.1016/j.schres.2008.11.011

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Cita questo

Spoletini, I., Cherubini, A., Di Paola, M., Banfi, G., Rusch, N., Martinotti, G., Bria, P., Rubino, I., Siracusano, A., Caltagirone, C., & Spalletta, G. (2009). Reduced fronto-temporal connectivity is associated with frontal gray matter density reduction and neuropsychological deficit in schizophrenia. Schizophrenia Research, 108, 57-68. https://doi.org/10.1016/j.schres.2008.11.011

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abstract = "A {"}disconnectivity model{"} of schizophrenia has been proposed, but it is still unclear if white mar abnormalities are associated with gray matter changes and if they may be the anatomic substrate of cognitive impairment, which is a core symptom of the disorder. The first objective was to detect if white matter microstructure alterations in schizophrenia are associated with or independent of gray matter change, using an optimized method for white matter (Tract-Based Spatial Statistics) and gray matter analyses (whole-brain voxel-wise approach). The second objective was to identify the neuropsychological correlates of white matter abnormalities in the schizophrenic group, using a comprehensive neuropsychological battery.",

keywords = "Schizophrenia, Schizophrenia",

author = "Ilaria Spoletini and A Cherubini and {Di Paola}, Margherita and G Banfi and N Rusch and Giovanni Martinotti and Pietro Bria and Ia Rubino and A Siracusano and C Caltagirone and Gianfranco Spalletta",

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Spoletini, I, Cherubini, A, Di Paola, M, Banfi, G, Rusch, N, Martinotti, G, Bria, P, Rubino, I, Siracusano, A, Caltagirone, C & Spalletta, G 2009, 'Reduced fronto-temporal connectivity is associated with frontal gray matter density reduction and neuropsychological deficit in schizophrenia.', Schizophrenia Research, vol. 108, pagg. 57-68. https://doi.org/10.1016/j.schres.2008.11.011

TY - JOUR

T1 - Reduced fronto-temporal connectivity is associated with frontal gray matter density reduction and neuropsychological deficit in schizophrenia.

AU - Spoletini, Ilaria

AU - Cherubini, A

AU - Di Paola, Margherita

AU - Banfi, G

AU - Rusch, N

AU - Martinotti, Giovanni

AU - Bria, Pietro

AU - Rubino, Ia

AU - Siracusano, A

AU - Caltagirone, C

AU - Spalletta, Gianfranco

PY - 2009

Y1 - 2009

N2 - A "disconnectivity model" of schizophrenia has been proposed, but it is still unclear if white mar abnormalities are associated with gray matter changes and if they may be the anatomic substrate of cognitive impairment, which is a core symptom of the disorder. The first objective was to detect if white matter microstructure alterations in schizophrenia are associated with or independent of gray matter change, using an optimized method for white matter (Tract-Based Spatial Statistics) and gray matter analyses (whole-brain voxel-wise approach). The second objective was to identify the neuropsychological correlates of white matter abnormalities in the schizophrenic group, using a comprehensive neuropsychological battery.

AB - A "disconnectivity model" of schizophrenia has been proposed, but it is still unclear if white mar abnormalities are associated with gray matter changes and if they may be the anatomic substrate of cognitive impairment, which is a core symptom of the disorder. The first objective was to detect if white matter microstructure alterations in schizophrenia are associated with or independent of gray matter change, using an optimized method for white matter (Tract-Based Spatial Statistics) and gray matter analyses (whole-brain voxel-wise approach). The second objective was to identify the neuropsychological correlates of white matter abnormalities in the schizophrenic group, using a comprehensive neuropsychological battery.

KW - Schizophrenia

UR - http://hdl.handle.net/10807/41642

U2 - 10.1016/j.schres.2008.11.011

DO - 10.1016/j.schres.2008.11.011

M3 - Article

SN - 0920-9964

VL - 108

SP - 57

EP - 68

JO - Schizophrenia Research

JF - Schizophrenia Research