Reduced Cancer Incidence in Huntington's Disease: Analysis in the Registry Study

Alberto Albanese, Anna Rita Bentivoglio, Paul Mcnulty, Richard Pilcher, Raviram Ramesh, Renata Necuiniate, Alis Hughes, Daniel Farewell, Peter Holmans, Lesley Jones, Raphael M. Bonelli, Karen Hecht, Brigitte Herranhof, Anna Holl, Hans-Peter Kapfhammer, Michael Koppitz, Sabine Lilek, Markus Magnet, Nicole Müller, Daniela OttiAnnamaria Painold, Karin Reisinger, Monika Scheibl, Helmut Schöggl, Jasmin Ullah, Eva-Maria Braunwarth, Florian Brugger, Lisa Buratti, Eva-Maria Hametner, Caroline Hepperger, Christiane Holas, Anna Hotter, Anna Hussl, Barbara Larcher, Philipp Mahlknecht, Christoph Müller, Bernadette Pinter, Werner Poewe, Eva-Magdalena Reiter, Klaus Seppi, Fabienne Sprenger, Gregor Wenning, Gunther Ladurner, Stefan Lilek, Daniela Sinadinosa, Wolfgang Staffen, Anna Maria Walleczek, Eric Constant, Anne-Françoise Gillardin, Marie-Claude Léonard, Christine Verellen-Dumoulin, Françoise Van De Wyngaerde, Michel Dupuis, Cécile Minet, Pascale Ribaï, Dominique Van Paemel, Andrea Boogaerts, Wim Vandenberghe, Dimphna Van Reijen, Michaela Kaiserova, Zuzana Šenkárová, Jiří Klempíř, Veronika Majerová, Jan Roth, Louise Hasselstrøm Madsen, Anette Torvin Møller, Lena Hjermind, Oda Jacobsen, Suzanne Lindquist, Jørgen Nielsen, Lisbeth Regeur, Jette Stockholm, Ida Unmack Larsen, Christina Vangsted-Hansen, Tua Vinther-Jensen, Annette Lolk, Marianne Lundsgaard, Lene Wermuth, Christian Andersson, Clara Nyberg, Jimmy Sundblom, Maarit Peippo, Marjett Sipponen, Paivi Hartikainen, Mari Ollokainen, Jaana Åman, Jaakko Ignatius, Mikko Kärppä, Aki Mustonen, Outi Kajula, Outi Jääskalainen, Jukka Moilanen, Maire Santala, Pia Eklund, Heli Hiivola, Hannele Hyppönen, Kirsti Martikainen, Katri Tuuha, Philippe Allain, Dominique Bonneau, Marie Bost, Bénédicte Gohier, Marie-Anne Guérid, Audrey Olivier, Julie Prouzet, Adriana Prundean, Clarisse Scherer-Gagou, Christophe Verny, Blandine Babiloni, Sabrina Debruxelles, Charlotte Duché, Cyril Goizet, Laetitia Jameau, Danielle Lafoucrière, Umberto Spampinato, Julien Couttier, Bérengère Debilly, Christine Delaigue, Franck Durif, Perrine Legendre, Sylvie Loiseau, Miguel Ulla, Tiphaine Vidal, Anne-Catherine Bachoud-Lévi, Farideh Badei, Marie-Françoise Boissé, Lotfi Boudali, Laurent Cleret De Langavant, Laurie Lemoine, Graca Morgado, Katia Youssov, Agnès Annic, Recka Barthélémy, Christelle De Bruycker, Maryline Cabaret, Anne-Sophie Carette, Nicolas Carrière, Eric Decorte, Luc Defebvre, Marie Delliaux, Arnaud Delval, Alizé Depelchin, Alain Destee, Nelly Dewulf-Pasz, Thibaut Dondaine, Florence Dugauquier, Kathy Dujardin, Lucie Hopes, Pierre Krystkowiak, Marie-Hélène Lemaire, Sylvie Manouvrier, Eugénie Mutez, Mireille Peter, Lucie Plomhause, Bernard Sablonnière, Clémence Simonin, Céline Tard, Stéphanie Thibault-Tanchou, Isabelle Vuillaume, Marcellin Bellonet, Alexandra Benoit, Hassan Berrisoul, Stéphanie Blin, Françoise Courtin, Cécile Duru, Véronique Fasquel, Mélanie Flament, Olivier Godefroy, Béatrice Mantaux, Alicia Playe, Martine Roussel, Mélissa Tir, Béatrice Schüler, Sandrine Wannepain, Jean-Philippe Azulay, Christelle Chabot, Marie Delfini, Alexandre Eusebio, Frédérique Fluchere, Hélène Grosjean, Laura Mundler, Marielle Nowak, Rolland Raseta, Sandra Benaich, Alexis Brice, Perrine Charles, Alexandra Durr, Claire Ewenczyk, Hélène Francisque, Céline Jauffret, Damian Justo, Abdulrahman Kassar, Stephan Klebe, Fabien Lesne, Paolo Milani, Marie-Lorraine Monin, Emmanuel Roze, Alina Tataru, Maya Tchikviladzé, Sandrine Bioux, Evangeline Bliaux, Carole Girard, Lucie Guyant-Maréchal, Didier Hannequin, Véronique Hannier, Séverine Jourdain, David Maltête, Dorothée Pouliquen, Ouhaid Lagha-Boukbiza, Nadine Longato, Christophe Marcel, Clélie Phillipps, Gabrielle Rudolf, Giséle Steinmetz, Christine Tranchant, Caroline Wagner, Marie-Agathe Zimmermann, Leily Blondeau, Fabienne Calvas, Samia Cheriet, Helène Delabaere, Jean-François Demonet, Jérémie Pariente, Michèle Pierre, Sandrine Rolland, Christoph Michael Kosinski, Eva Milkereit, Daniela Probst, Kathrin Reetz, Christian Sass, Johannes Schiefer, Christiane Schlangen, Cornelius J. Werner, Markus Beuth, Harald Gelderblom, Josef Priller, Harald Prüß, Eike Spruth, Silvia Thiel, Jürgen Andrich, Gisa Ellrichmann, Lennard Herrmann, Rainer Hoffmann, Barbara Kaminski, Peter Kraus, Carsten Saft, Christiane Stamm, Herwig Lange, Robert Maiwald, Cecile Bosredon, Ulrike Hunger, Matthias Löhle, Antonia Maass, Christiana Ossig, Simone Schmidt, Alexander Storch, Annett Wolz, Martin Wolz, Zacharias Kohl, Christina Kozay, Jürgen Winkler, Ulrike Bergmann, Regina Böringer, Philipp Capetian, Gerit Kammel, Johann Lambeck, Miriam Mächtel, Simone Meier, Michel Rijntjes, Birgit Zucker, Kai Boelmans, Christos Ganos, Ines Goerendt, Walburgis Heinicke, Ute Hidding, Jan Lewerenz, Alexander Münchau, Michael Orth, Jenny Schmalfeld, Lars Stubbe, Simone Zittel, Gabriele Diercks, Dirk Dressler, Flverly Francis, Sabine Gayde-Stephan, Heike Gorzolla, Bianca Kramer, Rebecca Minschke, Christoph Schrader, Pawel Tacik, Michael Ribbat, Bernhard Longinus, Antje Lüsebrink, Mark Mühlau, Alexander Peinemann, Michael Städtler, Adolf Weindl, Juliane Winkelmann, Cornelia Ziegler, Natalie Bechtel, Heike Beckmann, Stefan Bohlen, Nicole Göpfert, Eva Hölzner, Ralf Reilmann, Stefanie Rohm, Silke Rumpf, Sigrun Schepers, Nathalia Weber, Michael Bachmeier, Matthias Dose, Nina Hofstetter, Ralf Marquard, Alzbeta Mühlbäck, Katrin Barth, Andrea Buck, Julia Connemann, Daniel Ecker, Carolin Geitner, Christine Held, Andrea Kesse, Bernhard Landwehrmeyer, Franziska Lezius, Solveig Nepper, Anke Niess, Ariane Schneider, Daniela Schwenk, Sigurd Süssmuth, Sonja Trautmann, Melanie Vogel, Patrick Weydt, Thomas Musacchio, Christine Leypold, Kerstin Nöth, Claudia Cormio, Olimpia Difruscolo, Giovanni Franco, Vittorio Sciruicchio, Claudia Serpino, Marina De Tommaso, Giovanna Calandra-Buonaura, Sabina Capellari, Pietro Cortelli, Roberto Gallassi, Roberto Poda, Cesa Scaglione, Elisabetta Bertini, Elena Ghelli, Andrea Ginestroni, Claudia Mechi, Marco Paganini, Silvia Piacentini, Silvia Pradella, Anna Maria Romoli, Sandro Sorbi, Giovanni Abbruzzese, Monica Bandettini Di Poggio, Giovanna Ferrandes, Paola Mandich, Roberta Marchese, Emilio Di Maria, Simona Castagliuolo, Anna Castaldo, Stefano Di Donato, Daniela Di Bella, Cinzia Gellera, Silvia Genitrini, Caterina Mariotti, Daniela Monza, Lorenzo Nanetti, Marta Panzeri, Dominga Paridi, Paola Soliveri, Francesca Spagnolo, Franco Taroni, Chiara Tomasello, Giuseppe De Michele, Luigi Di Maio, Carlo Rinaldi, Marco Massarelli, Silvio Peluso, Alessandro Roca, Cinzia Valeria Russo, Elena Salvatore, Pierpaolo Sorrentino, Tecla Tucci, Milena Cannella, Valentina Codella, Francesca De Gregorio, Annunziata De Nicola, Francesca Elifani, Tiziana Martino, Irene Mazzante, Martina Petrollini, Maria Simonelli, Maurizio Vezza, Ferdinando Squitieri, Francesca Lovo, Giulia Coarelli, Michela Ferraldeschi, Giovanni Ristori, Monique S.E. Van Hout, Jeroen P.P. Van Vugt, A. Marit De Weert, Marloes Verhoeven, Meike Dekker, Nico Leenders, Joost Van Oostrom, Jesper Klooster, Berry Kremer, Verena Baake, Simon J.A. Van Den Bogaard, Reineke Bos, Eve M. Dumas, Ellen P. Hart'T, Anne Kampstra, Raymund A.C. Roos, Anne Schoonderbeek, Annelien Duits, Mayke Oosterloo, Mirella Waber, Carla Verstappen, Ellen Økland Blinkenberg, Erik Hauge, Hilde Tyvoll, Olaf Aaserud, Kathrine Bjørgo, Nancy Borgeød, Elisabeth Dramstad, Madeleine Fannemel, Jan C. Frich, Per F. Gørvell, Arvid Heiberg, Lars Retterstøl, Oddveig Røsby, Alma Sikiric, Bodil Stokke, Marleen Van Walsem, Ragnhild Wehus, Inga Bjørnevoll, Sigrid Botne Sando, Marte Gjøl Haug, Hanna Haugan Størseth, Vibeke Arntsen, Artur Dziadkiewicz, Malgorzata Nowak, Piotr Robowski, Emilia Sitek, Jaroslaw Slawek, Witold Soltan, Michal Szinwelski, Michal Arkuszewski, Magdalena Blaszczyk, Magdalena Boczarska-Jedynak, Ewelina Ciach-Wysocka, Agnieszka Gorzkowska, Barbara Jasińska-Myga, Aleksandra Kaczmarczyk, Gabriela Klodowska-Duda, Grzegorz Opala, Daniel Stompel, Krzysztof Banaszkiewicz, Dorota Boćwińska, Kamila Bojakowska-Jaremek, Malgorzata Dec, Natalia Grabska, Malgorzata Krawczyk, Ewelina Kubowicz, Michalina Malec-Litwinowicz, Monika Rudzińska, Agata Stenwak, Andrzej Szczudlik, Elzbieta Szczygiel, Magdalena Wójcik, Anna Wasielewska, Jacek Aniola, Anna Bryl, Anna Ciesielska, Aneta Klimberg, Jerzy Marcinkowski, Husam Samara, Justyna Sempolowicz, Bartlomiej Wiśniewski, Daniel Zielonka, Anna Gogol, Piotr Janik, Zygmunt Jamrozik, Anna Kaminska, Hubert Kwiecinski, Jakub Antczak, Katarzyna Jachinska, Wioletta Krysa, Maryla Rakowicz, Przemyslaw Richter, Rafal Rola, Danuta Ryglewicz, Halina Sienkiewicz-Jarosz, Iwona Stȩpniak, Anna Sulek, Grzegorz Witkowski, Jacek Zaremba, Elzbieta Zdzienicka, Karolina Ziora-Jakutowicz, Cristina Januário, Filipa Júlio, Manuel Almeida, Ana Calado, Margarida Dias, Joana Morgado, Cristina Semedo, Leonor Correia Guedes, Miguel Coelho, Joaquim J Ferreira, Tiago Mestre, Tiago Mendes, Anabela Valadas, Cristina Costa, Helena Cardoso, Carlos Andrade, Andreia Costa, Carolina Garrett, Miguel Gago, Joana Guimarães, João Massano, Joana Meireles, Ana Monteiro, Carmen Durán Herrera, Patrocinio Garcia Moreno, Jordi Bas, Núria Busquets, Matilde Calopa, Serge Jaumá Classen, Nadia Rodríguez Dedichá, María Teresa Buongiorno, Andrés De La Cerda Santa María, Esteban Muñoz, Pilar Santacruz, Miquel Aguilar Barbera, Ana Rojo Sebastián, Sonia Arribas Pardo, Dolors Badenes Guia, Noemi Calzado, Laura Casas Hernanz, Juan Pablo Tartari Díaz-Zorita, Judit López Catena, Pilar Quiléz Ferrer, Gemma Tome Carruesco, Misericordia Floriach Robert, Cèlia Mareca Viladrich, Elvira Roca, Jesús Miguel Ruiz Idiago, Antonio Villa Riballo, Antonia Campolongo, Ramon Fernandez De Bobadilla, Jaime Kulisevsky Bojarsky, Saul Martinez-Horta, Javier Pagonabarraga, Jesus Perez Perez, Roser Ribosa, Carolina Villa, Maria Angeles, Acera Gil, Koldo Berganzo Corrales, Juan Carlos Gomez Esteban, Amaia González, Beatriz Tijero Merino, Esther Cubo, Cecilia Gil Polo, Natividad Mariscal, Sandra Gutierrez Romero, José Matías Arbelo, Rocío Malo De Molina, Idaira Martín, Juan Manuel Periañez, Beatriz Udaeta, Fernando Alonso-Frech, María Del Valle Loarte, Francisco Barrero, Blas Morales, Belén Frades, Marina Ávila Villanueva, Maria Ascension Zea Sevilla, Fernando Alonso Frech, María Del Mar Fenollar, Rocío García-Ramos García, Clara Villanueva, Mónica Bascuñana Garde, Marta Fatás Ventura, Juan García Caldentey, Guillermo García Ribas, Justo García De Yébenes, José Luis López-Sendón Moreno, Verónica Mañanes Barral, Patricia Trigo Cubillo, Pedro José García Ruíz, Ana García, Rosa Guerrero López, Antonio Herranz Bárcenas, Asunción Martínez-Descals, Veronica Puertas Martin, Noelia Rodríguez Martínez, María José Sainz Artiga, Vicenta Sánchez, Angel Martínez Pueyo, Moreau María Dolores Alarcón, Carmen Antúnez Almagro, Esther Diéguez, Lorenza Fortuna, Salvadora Manzanares, Juan Marín Muñoz, María Martirio Antequera Torres, Fuensanta Noguera Perea, Laura Vivancos, Sonia González, Luis Menéndez Guisasola, Marta Para Prieto, René Ribacoba, Carlos Salvador, Pablo Sánchez Lozano, Inés Legarda Ramirez, Penelope Navas Arques, Monica Rodriguez Lopera, Barbara Vives Pastor, Itziar Gaston, Fermin Garcia-Amigot, Maria Dolores Martinez-Jaurrieta, Maria Antonia Ramos-Arroyo, Fátima Carrillo, María Teresa Cáceres Redondo, Pablo Mir, Laura Vargas González, Fátima Damas Hermoso, Jose Manuel García Moreno, Carolina Mendez Lucena, Eva María Pacheco Cortegana, José Chacón Peña, Luis Redondo, Violeta Sánchez Sánchez, Cristina Melgar Fernandez, María Dolores Romero Lemos, Maite Paredes Mata, Rocío Villagrán Casado, Maria Bosca, Juan Andres Burguera, Francisco Castera Brugada, Carmen Peiró Vilaplana, Pilar Solís, Begoña Jeweinat Figuerola, Paloma Millan Palanca, Jan Wahlström, Ulrika Høsterey-Ugander, Gunnel Fredlund, Radu Constantinescu, Liselotte Neleborn-Lingefjärd, Maria Berglund, Peter Berglund, Petra Linnsand, Elisabeth Björnsson, Martin Paucar, Sven Pålhagen, Per Svenningsson, Tina Wallden, Ghada Loutfi, Carina Olofsson, Eva-Lena Stattin, Laila Westman, Birgitta Wikström, Camilla Ekwall, Marie-Lousie Göller, Jean-Marc Burgunder, Yanik Stebler, Alain Kaelin, Irene Romero, Michael Schüpbach, Sabine Weber Zaugg, Federica Esposito, Jean-Marc Good, Karin Paus, Francois Vingerhoets, Christian Wider, Hans H. Jung, Jens A. Petersen, Maria Ligon-Auer, Violeta Mihaylova, Lorna Downie, Roisin Jack, Kirsty Matheson, Zosia Miedzybrodzka, Daniela Rae, Sheila A Simpson, Fiona Summers, Alexandra Ure, Vivien Vaughan, Timothy Harrower, Nathan Vernon, Shahbana Akhtar, Jenny Crooks, Adrienne Curtis, Jenny De Souza Keylock, Hugh Rickards, Jan Wright, Elizabeth Coulthard, Beverley Hayward, Kasia Sieradzan, Abigail Wright, Roger A. Barker, Deidre O'Keefe, Anna Gerrtiz Di Pietro, Kate Fisher, Anna Goodman, Susan Hill, Sarah Mason, Rachel Swain, Natalie Valle Guzman, Monica Busse, Cynthia Butcher, Stephen Dunnett, Catherine Clenaghan, Ruth Fullam, Sarah Hunt, Una Jones, Hanan Khalil, Sara Minster, Michael Owen, Kathleen Price, Jenny Townhill, Anne Rosser, David Goudie, Lindsay Buchanan, Paula Mcfadyen, Alison Tonner, Anne-Marie Taylor, Maureen Edwards, Carrie Ho, Marie Mcgill, Mary Porteous, Pauline Pearson, Sarah Irvine, Peter Brockie, Jillian Foster, Nicola Johns, Sue Mckenzie, Jean Rothery, Gareth Thomas, Shona Yates, Catherine Deith, Jane Ireland, Stuart Ritchie, Liz Burrows, Amy Fletcher, Alison Harding, Fiona Laver, Mark Silva, Aileen Thomson, Carol Chu, Carole Evans, Deena Gallentree, Stephanie Hamer, Alison Kraus, Ivana Markova, Ashok Raman, Alyson Andrew, Julie Frost, Rupert Noad, Emma Hobson, Stuart Jamieson, Mandy Longthorpe, Hannah Musgrave, Caroline Peacy, Liz Rowett, Jean Toscano, Sue Wild, Pam Yardumian, Carole Clayton, Heather Dipple, Dawn Freire-Patino, Caroline Hallam, Julia Middleton, Sundus Alusi, Rhys Davies, Kevin Foy, Emily Gerrans, Louise Pate, Uruj Anjum, Jan Coebergh, Charlotte Eddy, Nayana Lahiri, Meriel Mcentagart, Michael Patton, Maria Peterson, Sarah Rose, Thomasin Andrews, Andrew Dougherty, Charlotte Golding, Fred Kavalier, Hana Laing, Alison Lashwood, Dene Robertson, Deborah Ruddy, Alastair Santhouse, Anna Whaite, Stefania Bruno, Elvina Chu, Karen Doherty, Salman Haider, Davina Hensman, Monica Lewis, Marianne Novak, Aakta Patel, Nicola Robertson, Elisabeth Rosser, Sarah Tabrizi, Rachel Taylor, Thomas Warner, Edward Wild, Natalie Arran, Judith Bek, Jenny Callaghan, David Craufurd, Marianne Hare, Liz Howard, Susan Huson, Liz Johnson, Mary Jones, Ashok Krishnamoorthy, Helen Murphy, Emma Oughton, Lucy Partington-Jones, Dawn Rogers, Andrea Sollom, Julie Snowden, Cheryl Stopford, Jennifer Thompson, Iris Trender-Gerhard, Nicola Verstraelen, Leann Westmoreland, Ginette Cass, Lynn Davidson, Jill Davison, Suresh Komati, Sharon Mcdonnell, Zeid Mohammed, Karen Morgan, Lois Savage, Baldev Singh, Josh Wood, Caroline Knight, Mari O'Neill, Debasish Das Purkayastha, Andrea H Nemeth, Gill Siuda, Ruth Valentine, Richard Armstrong, David Harrison, Max Hughes, Sandra Large, John O Donovan, Amy Palmer, Andrew Parkinson, Beverley Soltysiak, Leanne Timings, Josh Williams, John Burn, Rebecca Weekes, Janet Craven, Wendy Bailey, Caroline Coleman, Diane Haig-Brown, Steve Simpson, Tahir Majeed, Oliver Bandmann, Alyson Bradbury, Helen Fairtlough, Kay Fillingham, Isabella Foustanos, Paul Gill, Mbombe Kazoka, Kirsty O'Donovan, Louise Nevitt, Nadia Peppa, Oliver Quarrell, Cat Taylor, Katherine Tidswell, Veena Agarwal, Mary Anderson, Kerry Gunner, Kayla Harris, Elaine Hayward, Melanie Heywood, Liane Keys, Lesley Mackinnon, Christopher Kipps, Sarah Smalley, Pamela Bethwaite, Rachel Edwards, Kathleen Fuller, Lesley Gowers, Michelle Phillips, Kingsley Powell, Ida Biunno, Juliana Bronzova, Joe Giuliano, Olivia J. Handley, Sergey Illarioshkin, Torsten Illmann, Jamie Levey, Tim Mclean, Susana Pro Koivisto, Markku Päivärinta, Tereza Uhrova, Sabrina Betz, Adrien Come, Selene Capodarca, Sébastien Charpentier, Wildson Vieira Da Silva, Martina Di Renzo, Ana Maria Finisterra, Camille Genoves, Mette Gilling, Carina Hvalstedt, Kerstin Koppers, Claudia Lamanna, Matilde Laurá, Kristina Münkel, Lisanne Mütze, Martin Oehmen, Helene Padieu, Laurent Paterski, Beate Rindal, Niini Røren, Pavla Šašinková, Yury Seliverstov, Erika Timewell, Marie-Noelle Witjes-Ané, Elizaveta Yudina, Eugeniusz Zielonka

Risultato della ricerca: Contributo in rivistaArticolo in rivista

7 Citazioni (Scopus)

Abstract

Background: People with Huntington's disease (HD) have been observed to have lower rates of cancers. Objective: To investigate the relationship between age of onset of HD, CAG repeat length, and cancer diagnosis. Methods: Data were obtained from the European Huntington's disease network REGISTRY study for 6540 subjects. Population cancer incidence was ascertained from the GLOBOCAN database to obtain standardised incidence ratios of cancers in the REGISTRY subjects. Results: 173/6528 HD REGISTRY subjects had had a cancer diagnosis. The age-standardised incidence rate of all cancers in the REGISTRY HD population was 0.26 (CI 0.22-0.30). Individual cancers showed a lower age-standardised incidence rate compared with the control population with prostate and colorectal cancers showing the lowest rates. There was no effect of CAG length on the likelihood of cancer, but a cancer diagnosis within the last year was associated with a greatly increased rate of HD onset (Hazard Ratio 18.94, p < 0.001). Conclusions: Cancer is less common than expected in the HD population, confirming previous reports. However, this does not appear to be related to CAG length in HTT. A recent diagnosis of cancer increases the risk of HD onset at any age, likely due to increased investigation following a cancer diagnosis.
Lingua originaleEnglish
pagine (da-a)209-222
Numero di pagine14
RivistaJOURNAL OF HUNTINGTON’S DISEASE
Volume7
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • Cellular and Molecular Neuroscience
  • Huntington's disease
  • Neurology (clinical)
  • cancer
  • neurodegeneration
  • trinucleotide repeat

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