Redox Balance via Lactate Dehydrogenase Is Important for Multiple Stress Resistance and Virulence in Enterococcus faecalis

Brunella Posteraro, Maurizio Sanguinetti, Nosheen Fatima Rana, Nicolas Sauvageot, Jean-Marie Laplace, Yin Yin Bao, Ingolf Nes, Alain Rincé, Axel Hartke

Risultato della ricerca: Contributo in rivistaArticolo in rivista

15 Citazioni (Scopus)

Abstract

Enterococcus faecalis is a highly stress resistant opportunistic pathogen. The intrinsic ruggedness of this bacterium is supposed to be the basis of its capacity to colonize the hostile environments of hospitals and to cause several kinds of infections. We show in this work that general resistance to very different environmental stresses depends on the ability of E. faecalis to maintain redox balance via lactate dehydrogenase (LDH). Furthermore, LDH-deficient mutants are less successful than the wild type at colonizing host organs in a murine model of systemic infection. Taken together, our results, as well as those previously published for Staphylococcus aureus (A. R. Richardson, S. J. Libby, and F. C. Fang, Science 319:1672-1676, 2008), identify LDH as an attractive drug target. These drugs may have additional applications, as in the fight against glycopeptide antibiotic-resistant bacteria and even cancer.
Lingua originaleEnglish
pagine (da-a)2662-2668
Numero di pagine7
RivistaInfection and Immunity
Volume81
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • Enterococcus faecalis

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