TY - JOUR
T1 - Redox Balance via Lactate Dehydrogenase Is Important for Multiple Stress Resistance and Virulence in Enterococcus faecalis
AU - Fatima Rana, Nosheen
AU - Sauvageot, Nicolas
AU - Laplace, Jean-Marie
AU - Bao, Yin Yin
AU - Nes, Ingolf
AU - Rincé, Alain
AU - Posteraro, Brunella
AU - Sanguinetti, Maurizio
AU - Hartke, Axel
PY - 2013
Y1 - 2013
N2 - Enterococcus faecalis is a highly stress resistant opportunistic pathogen. The intrinsic ruggedness of this bacterium is supposed to be the basis of its capacity to colonize the hostile environments of hospitals and to cause several kinds of infections. We show in this work that general resistance to very different environmental stresses depends on the ability of E. faecalis to maintain redox balance via lactate dehydrogenase (LDH). Furthermore, LDH-deficient mutants are less successful than the wild type at colonizing host organs in a murine model of systemic infection. Taken together, our results, as well as those previously published for Staphylococcus aureus (A. R. Richardson, S. J. Libby, and F. C. Fang, Science 319:1672-1676, 2008), identify LDH as an attractive drug target. These drugs may have additional applications, as in the fight against glycopeptide antibiotic-resistant bacteria and even cancer.
AB - Enterococcus faecalis is a highly stress resistant opportunistic pathogen. The intrinsic ruggedness of this bacterium is supposed to be the basis of its capacity to colonize the hostile environments of hospitals and to cause several kinds of infections. We show in this work that general resistance to very different environmental stresses depends on the ability of E. faecalis to maintain redox balance via lactate dehydrogenase (LDH). Furthermore, LDH-deficient mutants are less successful than the wild type at colonizing host organs in a murine model of systemic infection. Taken together, our results, as well as those previously published for Staphylococcus aureus (A. R. Richardson, S. J. Libby, and F. C. Fang, Science 319:1672-1676, 2008), identify LDH as an attractive drug target. These drugs may have additional applications, as in the fight against glycopeptide antibiotic-resistant bacteria and even cancer.
KW - Enterococcus faecalis
KW - Enterococcus faecalis
UR - http://hdl.handle.net/10807/48092
U2 - 10.1128/IAI.01299-12
DO - 10.1128/IAI.01299-12
M3 - Article
SN - 0019-9567
VL - 81
SP - 2662
EP - 2668
JO - Infection and Immunity
JF - Infection and Immunity
ER -