Recurrent upper airway infections and bacterial biofilms.

Jacopo Galli, Fausta Ardito, Lea Calo', Livia Mancinelli, Micaela Imperiali, Claudio Parrilla, Pasqualina Maria Picciotti, Guido Fadda

Risultato della ricerca: Contributo in rivistaArticolo in rivista


Bacterial biofilms identified in various medical devices used in otorhinolaryngology, including tympanostomy tubes, voice prostheses, and cochlear implants, can directly colonise mucosal tissues. The upper airways seem to be at high risk for this type of colonisation. Chronic and/or recurrent upper airway infections may be related to the complex structural and biochemical (quorum sensing) organisation of the biofilm which interferes with the activity of antibiotics (including those with proven in vitro efficacy), thus promoting the establishment of a chronic infection eradicable only by surgical treatment. Biofilm formation plays a role in upper respiratory infections: it not only explains the resistance of these infections to antibiotic therapy but it also represents an important element that contributes to the maintenance of a chronic inflammatory reaction.
Lingua originaleEnglish
pagine (da-a)121(4)-4
Numero di pagine341
RivistaJournal of Laryngology and Otology
Stato di pubblicazionePubblicato - 2007


  • biofilms


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