Recurrent herpes simplex virus-1 infection induces hallmarks of neurodegeneration and cognitive deficits in mice

Roberto Piacentini, Domenica Donatella Li Puma, Claudio Grassi, Alessia Mastrodonato, Maria Elena Marcocci, Giovanna De Chiara, Marco Fabiani, Dolores Limongi, Giorgia Napoletani, Virginia Protto, Paolo Coluccio, Ignacio Celestino, Anna Teresa Palamara

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

57 Citazioni (Scopus)

Abstract

Herpes simplex virus type 1 (HSV-1) is a DNA neurotropic virus, usually establishing latent infections in the trigeminal ganglia followed by periodic reactivations. Although numerous findings suggested potential links between HSV-1 and Alzheimer's disease (AD), a causal relation has not been demonstrated yet. Hence, we set up a model of recurrent HSV-1 infection in mice undergoing repeated cycles of viral reactivation. By virological and molecular analyses we found: i) HSV-1 spreading and replication in different brain regions after thermal stress-induced virus reactivations; ii) accumulation of AD hallmarks including amyloid-β protein, tau hyperphosphorylation, and neuroinflammation markers (astrogliosis, IL-1β and IL-6). Remarkably, the progressive accumulation of AD molecular biomarkers in neocortex and hippocampus of HSV-1 infected mice, triggered by repeated virus reactivations, correlated with increasing cognitive deficits becoming irreversible after seven cycles of reactivation. Collectively, our findings provide evidence that mild and recurrent HSV-1 infections in the central nervous system produce an AD-like phenotype and suggest that they are a risk factor for AD.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
Numero di pagine30
RivistaPLoS Pathogens
Volume15
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • Alzheimer's disease
  • HSV-1 infected
  • herpes simplex virus-1
  • neurodegeneration

Fingerprint

Entra nei temi di ricerca di 'Recurrent herpes simplex virus-1 infection induces hallmarks of neurodegeneration and cognitive deficits in mice'. Insieme formano una fingerprint unica.

Cita questo