Recurrent candidiasis and early-onset gastric cancer in a patient with a genetically defined partial MYD88

MJ Ligtenberg; RS van der Post; RM de Voer; CM Kets; TJ Jansen; L Jacobs; G Schreibelt; J International Gastric Cancer Genetics Group (Lubinski; A Jakubowska; U Teodorczyk; HK Schackert; CM Aalfs; Maurizio Genuardi; EB Gómez García; GN Ranzani; V Molinaro; LP van Hest; FJ Hes; E Holinski-Feder; MG Ausems; RH Sijmons; A Wagner; LE van der Kolk; H Pinheiro; C Oliveira; I Bjørnevoll; HH Vetti; J van Krieken; de Vries; IJ; MG Netea; N Hoogerbrugge

doi:10.1007/s10689-015-9859-z

Recurrent candidiasis and early-onset gastric cancer in a patient with a genetically defined partial MYD88

MJ Ligtenberg, RS van der Post, RM de Voer, CM Kets, TJ Jansen, L Jacobs, G Schreibelt, J International Gastric Cancer Genetics Group (Lubinski, A Jakubowska, U Teodorczyk, HK Schackert, CM Aalfs, Maurizio Genuardi, EB Gómez García, GN Ranzani, V Molinaro, LP van Hest, FJ Hes, E Holinski-Feder, MG AusemsRH Sijmons, A Wagner, LE van der Kolk, H Pinheiro, C Oliveira, I Bjørnevoll, HH Vetti, J van Krieken, de Vries, IJ, MG Netea, N Hoogerbrugge^*

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo

9 Citazioni (Scopus)

Abstract

Gastric cancer is caused by both genetic and environmental factors. A woman who suffered from recurrent candidiasis throughout her life developed diffuse-type gastric cancer at the age of 23 years. Using whole-exome sequencing we identified a germline homozygous missense variant in MYD88. Immunological assays on peripheral blood mononuclear cells revealed an impaired immune response upon stimulation with Candida albicans, characterized by a defective production of the cytokine interleukin-17. Our data suggest that a genetic defect in MYD88 results in an impaired immune response and may increase gastric cancer risk.

Lingua originale	Inglese
pagine (da-a)	289-296
Numero di pagine	8
Rivista	Familial Cancer
Volume	2016
Numero di pubblicazione	15
DOI	https://doi.org/10.1007/s10689-015-9859-z
Stato di pubblicazione	Pubblicato - 2017

All Science Journal Classification (ASJC) codes

Genetica
Oncologia
Genetica (clinica)
Ricerca sul Cancro

Keywords

cancer

OSS delle Nazioni Unite

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10.1007/s10689-015-9859-z

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Ligtenberg, MJ., van der Post, RS., de Voer, RM., Kets, CM., Jansen, TJ., Jacobs, L., Schreibelt, G., International Gastric Cancer Genetics Group (Lubinski, J., Jakubowska, A., Teodorczyk, U., Schackert, HK., Aalfs, CM., Genuardi, M., Gómez García, EB., Ranzani, GN., Molinaro, V., van Hest, LP., Hes, FJ., Holinski-Feder, E., ... Hoogerbrugge, N. (2017). Recurrent candidiasis and early-onset gastric cancer in a patient with a genetically defined partial MYD88. Familial Cancer, 2016(15), 289-296. https://doi.org/10.1007/s10689-015-9859-z

@article{b1c370861955479e84ede9c1855b0610,

title = "Recurrent candidiasis and early-onset gastric cancer in a patient with a genetically defined partial MYD88",

abstract = "Gastric cancer is caused by both genetic and environmental factors. A woman who suffered from recurrent candidiasis throughout her life developed diffuse-type gastric cancer at the age of 23 years. Using whole-exome sequencing we identified a germline homozygous missense variant in MYD88. Immunological assays on peripheral blood mononuclear cells revealed an impaired immune response upon stimulation with Candida albicans, characterized by a defective production of the cytokine interleukin-17. Our data suggest that a genetic defect in MYD88 results in an impaired immune response and may increase gastric cancer risk.",

keywords = "cancer, cancer",

author = "MJ Ligtenberg and {van der Post}, RS and {de Voer}, RM and CM Kets and TJ Jansen and L Jacobs and G Schreibelt and {International Gastric Cancer Genetics Group (Lubinski}, J and A Jakubowska and U Teodorczyk and HK Schackert and CM Aalfs and Maurizio Genuardi and {G{\'o}mez Garc{\'i}a}, EB and GN Ranzani and V Molinaro and {van Hest}, LP and FJ Hes and E Holinski-Feder and MG Ausems and RH Sijmons and A Wagner and {van der Kolk}, LE and H Pinheiro and C Oliveira and I Bj{\o}rnevoll and HH Vetti and {van Krieken}, J and {de Vries} and IJ and MG Netea and N Hoogerbrugge",

year = "2017",

doi = "10.1007/s10689-015-9859-z",

language = "English",

volume = "2016",

pages = "289--296",

journal = "Familial Cancer",

issn = "1389-9600",

publisher = "Springer Science and Business Media B.V.",

number = "15",

}

Ligtenberg, MJ, van der Post, RS, de Voer, RM, Kets, CM, Jansen, TJ, Jacobs, L, Schreibelt, G, International Gastric Cancer Genetics Group (Lubinski, J, Jakubowska, A, Teodorczyk, U, Schackert, HK, Aalfs, CM, Genuardi, M, Gómez García, EB, Ranzani, GN, Molinaro, V, van Hest, LP, Hes, FJ, Holinski-Feder, E, Ausems, MG, Sijmons, RH, Wagner, A, van der Kolk, LE, Pinheiro, H, Oliveira, C, Bjørnevoll, I, Vetti, HH, van Krieken, J, de Vries, IJ, Netea, MG & Hoogerbrugge, N 2017, 'Recurrent candidiasis and early-onset gastric cancer in a patient with a genetically defined partial MYD88', Familial Cancer, vol. 2016, n. 15, pagg. 289-296. https://doi.org/10.1007/s10689-015-9859-z

TY - JOUR

T1 - Recurrent candidiasis and early-onset gastric cancer in a patient with a genetically defined partial MYD88

AU - Ligtenberg, MJ

AU - van der Post, RS

AU - de Voer, RM

AU - Kets, CM

AU - Jansen, TJ

AU - Jacobs, L

AU - Schreibelt, G

AU - International Gastric Cancer Genetics Group (Lubinski, J

AU - Jakubowska, A

AU - Teodorczyk, U

AU - Schackert, HK

AU - Aalfs, CM

AU - Genuardi, Maurizio

AU - Gómez García, EB

AU - Ranzani, GN

AU - Molinaro, V

AU - van Hest, LP

AU - Hes, FJ

AU - Holinski-Feder, E

AU - Ausems, MG

AU - Sijmons, RH

AU - Wagner, A

AU - van der Kolk, LE

AU - Pinheiro, H

AU - Oliveira, C

AU - Bjørnevoll, I

AU - Vetti, HH

AU - van Krieken, J

AU - de Vries,

AU - IJ, null

AU - Netea, MG

AU - Hoogerbrugge, N

PY - 2017

Y1 - 2017

N2 - Gastric cancer is caused by both genetic and environmental factors. A woman who suffered from recurrent candidiasis throughout her life developed diffuse-type gastric cancer at the age of 23 years. Using whole-exome sequencing we identified a germline homozygous missense variant in MYD88. Immunological assays on peripheral blood mononuclear cells revealed an impaired immune response upon stimulation with Candida albicans, characterized by a defective production of the cytokine interleukin-17. Our data suggest that a genetic defect in MYD88 results in an impaired immune response and may increase gastric cancer risk.

AB - Gastric cancer is caused by both genetic and environmental factors. A woman who suffered from recurrent candidiasis throughout her life developed diffuse-type gastric cancer at the age of 23 years. Using whole-exome sequencing we identified a germline homozygous missense variant in MYD88. Immunological assays on peripheral blood mononuclear cells revealed an impaired immune response upon stimulation with Candida albicans, characterized by a defective production of the cytokine interleukin-17. Our data suggest that a genetic defect in MYD88 results in an impaired immune response and may increase gastric cancer risk.

KW - cancer

UR - https://publicatt.unicatt.it/handle/10807/148672

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U2 - 10.1007/s10689-015-9859-z

DO - 10.1007/s10689-015-9859-z

M3 - Article

SN - 1389-9600

VL - 2016

SP - 289

EP - 296

JO - Familial Cancer

JF - Familial Cancer

IS - 15

ER -

Recurrent candidiasis and early-onset gastric cancer in a patient with a genetically defined partial MYD88

Abstract

All Science Journal Classification (ASJC) codes

Keywords

OSS delle Nazioni Unite

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