Recurrent candidiasis and early-onset gastric cancer in a patient with a genetically defined partial MYD88

Maurizio Genuardi; Ingrid P. Vogelaar; Marjolijn J. L. Ligtenberg; Rachel S. Van Der Post; Richarda M. De Voer; C. Marleen Kets; Trees J. G. Jansen; Liesbeth Jacobs; Gerty Schreibelt; I. Jolanda M. De Vries; Mihai G. Netea; Nicoline Hoogerbrugge; Jan Lubinski; Anna Jakubowska; Urszula Teodorczyk; Hans K. Schackert; Cora M. Aalfs; Encarna B. Gómez García; Guglielmina N. Ranzani; Valeria Molinaro; Liselotte P. Van Hest; Frederik J. Hes; Elke Holinski-Feder; Margreet G. E. M. Ausems; Rolf H. Sijmons; Anja Wagner; Lizet E. Van Der Kolk; Hugo Pinheiro; Carla Oliveira; Inga Bjørnevoll; Hildegunn Høberg Vetti; J. Han; J. M. Van Krieken

doi:10.1007/s10689-015-9859-z

Recurrent candidiasis and early-onset gastric cancer in a patient with a genetically defined partial MYD88

Maurizio Genuardi, Ingrid P. Vogelaar, Marjolijn J. L. Ligtenberg, Rachel S. Van Der Post, Richarda M. De Voer, C. Marleen Kets, Trees J. G. Jansen, Liesbeth Jacobs, Gerty Schreibelt, I. Jolanda M. De Vries, Mihai G. Netea, Nicoline Hoogerbrugge, Jan Lubinski, Anna Jakubowska, Urszula Teodorczyk, Hans K. Schackert, Cora M. Aalfs, Encarna B. Gómez García, Guglielmina N. Ranzani, Valeria MolinaroLiselotte P. Van Hest, Frederik J. Hes, Elke Holinski-Feder, Margreet G. E. M. Ausems, Rolf H. Sijmons, Anja Wagner, Lizet E. Van Der Kolk, Hugo Pinheiro, Carla Oliveira, Inga Bjørnevoll, Hildegunn Høberg Vetti, J. Han, J. M. Van Krieken

Risultato della ricerca: Contributo in rivista › Articolo in rivista

9 Citazioni (Scopus)

Abstract

Gastric cancer is caused by both genetic and environmental factors. A woman who suffered from recurrent candidiasis throughout her life developed diffuse-type gastric cancer at the age of 23 years. Using whole-exome sequencing we identified a germline homozygous missense variant in MYD88. Immunological assays on peripheral blood mononuclear cells revealed an impaired immune response upon stimulation with Candida albicans, characterized by a defective production of the cytokine interleukin-17. Our data suggest that a genetic defect in MYD88 results in an impaired immune response and may increase gastric cancer risk.

Lingua originale	English
pagine (da-a)	289-296
Numero di pagine	8
Rivista	Familial Cancer
Volume	2016
DOI	https://doi.org/10.1007/s10689-015-9859-z
Stato di pubblicazione	Pubblicato - 2017

Keywords

cancer

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10.1007/s10689-015-9859-z

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Genuardi, M., Vogelaar, I. P., Ligtenberg, M. J. L., Van Der Post, R. S., De Voer, R. M., Kets, C. M., Jansen, T. J. G., Jacobs, L., Schreibelt, G., De Vries, I. J. M., Netea, M. G., Hoogerbrugge, N., Lubinski, J., Jakubowska, A., Teodorczyk, U., Schackert, H. K., Aalfs, C. M., Gómez García, E. B., Ranzani, G. N., ... Van Krieken, J. M. (2017). Recurrent candidiasis and early-onset gastric cancer in a patient with a genetically defined partial MYD88. Familial Cancer, 2016, 289-296. https://doi.org/10.1007/s10689-015-9859-z

@article{b1c370861955479e84ede9c1855b0610,

title = "Recurrent candidiasis and early-onset gastric cancer in a patient with a genetically defined partial MYD88",

abstract = "Gastric cancer is caused by both genetic and environmental factors. A woman who suffered from recurrent candidiasis throughout her life developed diffuse-type gastric cancer at the age of 23 years. Using whole-exome sequencing we identified a germline homozygous missense variant in MYD88. Immunological assays on peripheral blood mononuclear cells revealed an impaired immune response upon stimulation with Candida albicans, characterized by a defective production of the cytokine interleukin-17. Our data suggest that a genetic defect in MYD88 results in an impaired immune response and may increase gastric cancer risk.",

keywords = "cancer, cancer",

author = "Maurizio Genuardi and Vogelaar, {Ingrid P.} and Ligtenberg, {Marjolijn J. L.} and {Van Der Post}, {Rachel S.} and {De Voer}, {Richarda M.} and Kets, {C. Marleen} and Jansen, {Trees J. G.} and Liesbeth Jacobs and Gerty Schreibelt and {De Vries}, {I. Jolanda M.} and Netea, {Mihai G.} and Nicoline Hoogerbrugge and Jan Lubinski and Anna Jakubowska and Urszula Teodorczyk and Schackert, {Hans K.} and Aalfs, {Cora M.} and {G{\'o}mez Garc{\'i}a}, {Encarna B.} and Ranzani, {Guglielmina N.} and Valeria Molinaro and {Van Hest}, {Liselotte P.} and Hes, {Frederik J.} and Elke Holinski-Feder and Ausems, {Margreet G. E. M.} and Sijmons, {Rolf H.} and Anja Wagner and {Van Der Kolk}, {Lizet E.} and Hugo Pinheiro and Carla Oliveira and Inga Bj{\o}rnevoll and {H{\o}berg Vetti}, Hildegunn and J. Han and {Van Krieken}, {J. M.}",

year = "2017",

doi = "10.1007/s10689-015-9859-z",

language = "English",

volume = "2016",

pages = "289--296",

journal = "Familial Cancer",

issn = "1389-9600",

publisher = "Kluwer Academic Publishers, Dordrecht ; Boston",

}

Genuardi, M, Vogelaar, IP, Ligtenberg, MJL, Van Der Post, RS, De Voer, RM, Kets, CM, Jansen, TJG, Jacobs, L, Schreibelt, G, De Vries, IJM, Netea, MG, Hoogerbrugge, N, Lubinski, J, Jakubowska, A, Teodorczyk, U, Schackert, HK, Aalfs, CM, Gómez García, EB, Ranzani, GN, Molinaro, V, Van Hest, LP, Hes, FJ, Holinski-Feder, E, Ausems, MGEM, Sijmons, RH, Wagner, A, Van Der Kolk, LE, Pinheiro, H, Oliveira, C, Bjørnevoll, I, Høberg Vetti, H, Han, J & Van Krieken, JM 2017, 'Recurrent candidiasis and early-onset gastric cancer in a patient with a genetically defined partial MYD88', Familial Cancer, vol. 2016, pagg. 289-296. https://doi.org/10.1007/s10689-015-9859-z

TY - JOUR

T1 - Recurrent candidiasis and early-onset gastric cancer in a patient with a genetically defined partial MYD88

AU - Genuardi, Maurizio

AU - Vogelaar, Ingrid P.

AU - Ligtenberg, Marjolijn J. L.

AU - Van Der Post, Rachel S.

AU - De Voer, Richarda M.

AU - Kets, C. Marleen

AU - Jansen, Trees J. G.

AU - Jacobs, Liesbeth

AU - Schreibelt, Gerty

AU - De Vries, I. Jolanda M.

AU - Netea, Mihai G.

AU - Hoogerbrugge, Nicoline

AU - Lubinski, Jan

AU - Jakubowska, Anna

AU - Teodorczyk, Urszula

AU - Schackert, Hans K.

AU - Aalfs, Cora M.

AU - Gómez García, Encarna B.

AU - Ranzani, Guglielmina N.

AU - Molinaro, Valeria

AU - Van Hest, Liselotte P.

AU - Hes, Frederik J.

AU - Holinski-Feder, Elke

AU - Ausems, Margreet G. E. M.

AU - Sijmons, Rolf H.

AU - Wagner, Anja

AU - Van Der Kolk, Lizet E.

AU - Pinheiro, Hugo

AU - Oliveira, Carla

AU - Bjørnevoll, Inga

AU - Høberg Vetti, Hildegunn

AU - Han, J.

AU - Van Krieken, J. M.

PY - 2017

Y1 - 2017

N2 - Gastric cancer is caused by both genetic and environmental factors. A woman who suffered from recurrent candidiasis throughout her life developed diffuse-type gastric cancer at the age of 23 years. Using whole-exome sequencing we identified a germline homozygous missense variant in MYD88. Immunological assays on peripheral blood mononuclear cells revealed an impaired immune response upon stimulation with Candida albicans, characterized by a defective production of the cytokine interleukin-17. Our data suggest that a genetic defect in MYD88 results in an impaired immune response and may increase gastric cancer risk.

AB - Gastric cancer is caused by both genetic and environmental factors. A woman who suffered from recurrent candidiasis throughout her life developed diffuse-type gastric cancer at the age of 23 years. Using whole-exome sequencing we identified a germline homozygous missense variant in MYD88. Immunological assays on peripheral blood mononuclear cells revealed an impaired immune response upon stimulation with Candida albicans, characterized by a defective production of the cytokine interleukin-17. Our data suggest that a genetic defect in MYD88 results in an impaired immune response and may increase gastric cancer risk.

KW - cancer

UR - http://hdl.handle.net/10807/148672

U2 - 10.1007/s10689-015-9859-z

DO - 10.1007/s10689-015-9859-z

M3 - Article

VL - 2016

SP - 289

EP - 296

JO - Familial Cancer

JF - Familial Cancer

SN - 1389-9600

ER -

Recurrent candidiasis and early-onset gastric cancer in a patient with a genetically defined partial MYD88

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Keywords

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