Abstract
Gastric cancer is caused by both genetic and environmental factors. A woman who suffered from recurrent candidiasis throughout her life developed diffuse-type gastric cancer at the age of 23 years. Using whole-exome sequencing we identified a germline homozygous missense variant in MYD88. Immunological assays on peripheral blood mononuclear cells revealed an impaired immune response upon stimulation with Candida albicans, characterized by a defective production of the cytokine interleukin-17. Our data suggest that a genetic defect in MYD88 results in an impaired immune response and may increase gastric cancer risk.
Lingua originale | English |
---|---|
pagine (da-a) | 289-296 |
Numero di pagine | 8 |
Rivista | Familial Cancer |
Volume | 2016 |
DOI | |
Stato di pubblicazione | Pubblicato - 2017 |
Keywords
- cancer