Recurrent candidiasis and early-onset gastric cancer in a patient with a genetically defined partial MYD88

Risultato della ricerca: Contributo in rivistaArticolo in rivista

9 Citazioni (Scopus)

Abstract

Gastric cancer is caused by both genetic and environmental factors. A woman who suffered from recurrent candidiasis throughout her life developed diffuse-type gastric cancer at the age of 23 years. Using whole-exome sequencing we identified a germline homozygous missense variant in MYD88. Immunological assays on peripheral blood mononuclear cells revealed an impaired immune response upon stimulation with Candida albicans, characterized by a defective production of the cytokine interleukin-17. Our data suggest that a genetic defect in MYD88 results in an impaired immune response and may increase gastric cancer risk.
Lingua originaleEnglish
pagine (da-a)289-296
Numero di pagine8
RivistaFamilial Cancer
Volume2016
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • cancer

Fingerprint

Entra nei temi di ricerca di 'Recurrent candidiasis and early-onset gastric cancer in a patient with a genetically defined partial MYD88'. Insieme formano una fingerprint unica.

Cita questo