@article{3659e824f3bc48678268b642a7958832,
title = "Recurrent candidiasis and early-onset gastric cancer in a patient with a genetically defined partial MYD88 defect",
abstract = "Gastric cancer is caused by both genetic and environmental factors. A woman who suffered from recurrent candidiasis throughout her life developed diffuse-type gastric cancer at the age of 23 years. Using whole-exome sequencing we identified a germline homozygous missense variant in MYD88. Immunological assays on peripheral blood mononuclear cells revealed an impaired immune response upon stimulation with Candida albicans, characterized by a defective production of the cytokine interleukin-17. Our data suggest that a genetic defect in MYD88 results in an impaired immune response and may increase gastric cancer risk.",
keywords = "Adult, Cancer Research, Candida albicans, Candidaalbicans, Candidiasis, Female, Gastric cancer, Genetics, Genetics (clinical), Helicobacter Infections, Homozygote, Humans, Interleukin-17, MYD88, Myeloid Differentiation Factor 88, Oncology, Stomach Neoplasms, Th17 response, Adult, Cancer Research, Candida albicans, Candidaalbicans, Candidiasis, Female, Gastric cancer, Genetics, Genetics (clinical), Helicobacter Infections, Homozygote, Humans, Interleukin-17, MYD88, Myeloid Differentiation Factor 88, Oncology, Stomach Neoplasms, Th17 response",
author = "Vogelaar, {Ingrid P.} and Ligtenberg, {Marjolijn J. L.} and {Van Der Post}, {Rachel S.} and {De Voer}, {Richarda M.} and Kets, {C. Marleen} and Jansen, {Trees J. G.} and Liesbeth Jacobs and Gerty Schreibelt and {De Vries}, {I. Jolanda M.} and Netea, {Mihai G.} and Nicoline Hoogerbrugge and Jan Lubinski and Anna Jakubowska and Urszula Teodorczyk and Schackert, {Hans K.} and Aalfs, {Cora M.} and {G{\'o}mez Garc{\'i}a}, {Encarna B.} and Ranzani, {Guglielmina N.} and Valeria Molinaro and {Van Hest}, {Liselotte P.} and Hes, {Frederik J.} and Elke Holinski-Feder and Maurizio Genuardi and Ausems, {Margreet G. E. M.} and Sijmons, {Rolf H.} and Anja Wagner and {Van Der Kolk}, {Lizet E.} and Hugo Pinheiro and Carla Oliveira and Inga Bj{\o}rnevoll and {H{\o}berg Vetti}, Hildegunn and J. Han and {Van Krieken}, {J. M.}",
year = "2016",
doi = "10.1007/s10689-015-9859-z",
language = "English",
volume = "15",
pages = "289--296",
journal = "Familial Cancer",
issn = "1389-9600",
publisher = "Springer Science and Business Media B.V.",
}