TY - JOUR
T1 - Recovery Time after Hemodialysis Is Inversely Associated with the Ultrafiltration Rate
AU - Bossola, Maurizio
AU - Di Stasio, Enrico
AU - Monteburini, Tania
AU - Parodi, Emanuele
AU - Ippoliti, Fabio
AU - Cenerelli, Stefano
AU - Santarelli, Stefano
AU - Santarelli, Stefania
AU - Nebiolo, Pier Eugenio
AU - Sirolli, Vittorio
AU - Bonomini, Mario
AU - Antocicco, Manuela
AU - Zuccala', Giuseppe
AU - Laudisio, Alice
PY - 2019
Y1 - 2019
N2 - Introduction: The present study aimed to determine the
variables that are associated with a longer dialysis recovery
time (DRT) and to define the relationship that exists between
DRT and the ultrafiltration rate (UFR) in prevalent chronic hemodialysis (CHD) patients. Methods: We studied 210 prevalent CHD of 5 hemodialysis units in Central Italy. Patients
were invited to answer to the question: “How long does it
take you to recover from a dialysis session?” Answers to this
question were subsequently converted into minutes. Demographic, clinical and laboratory parameters were recorded
for each patient as well as the UFR (mL/kg/h), the dialysate
sodium concentration and temperature. Results: Median
DRT was 180 min (60–420). Ninety five (45%) patients had a
DRT ≥ the median value. Mean UFR was 9.2 ± 3.0 mL/kg/h.
Patients with a lower DRT had a less prevalent disability in
the instrumental activities daily living, had a higher UFR, and
a lower dialysate temperature, as compared with subjects
with higher DRT. According to the logistic regression model,
UFR was associated with a DRT below the median (i.e., 180)
in the unadjusted model (OR 1.12; 95% CI 1.02–1.23; p =
0.019), after adjusting for age and sex (OR 1.11; 95% CI 1.01–
1.22; p = 0.025), and in the fully adjusted model (OR 1.11; 95%
CI 1.04–1.22; p = 0.040). UFR increase was associated with
increasing probability of DRT below the median (p for trend=
0.035). The highest tertile of DRT was associated with UFR
below the mean value (i.e., 9.2 mL/kg/h) in multinomial logistic regression having the lowest DRT tertile as reference.
DRT was significantly lower in patients with UFR >13 mL/
kg/h than in patients with UFR 10–13 or <10 mL/kg/h. Conclusion: DRT is inversely associated with UFR in CHD patients. Whether a high UFR should be recommended to reduce the DRT needs to be elucidated through an adequate
prospective randomized study.
AB - Introduction: The present study aimed to determine the
variables that are associated with a longer dialysis recovery
time (DRT) and to define the relationship that exists between
DRT and the ultrafiltration rate (UFR) in prevalent chronic hemodialysis (CHD) patients. Methods: We studied 210 prevalent CHD of 5 hemodialysis units in Central Italy. Patients
were invited to answer to the question: “How long does it
take you to recover from a dialysis session?” Answers to this
question were subsequently converted into minutes. Demographic, clinical and laboratory parameters were recorded
for each patient as well as the UFR (mL/kg/h), the dialysate
sodium concentration and temperature. Results: Median
DRT was 180 min (60–420). Ninety five (45%) patients had a
DRT ≥ the median value. Mean UFR was 9.2 ± 3.0 mL/kg/h.
Patients with a lower DRT had a less prevalent disability in
the instrumental activities daily living, had a higher UFR, and
a lower dialysate temperature, as compared with subjects
with higher DRT. According to the logistic regression model,
UFR was associated with a DRT below the median (i.e., 180)
in the unadjusted model (OR 1.12; 95% CI 1.02–1.23; p =
0.019), after adjusting for age and sex (OR 1.11; 95% CI 1.01–
1.22; p = 0.025), and in the fully adjusted model (OR 1.11; 95%
CI 1.04–1.22; p = 0.040). UFR increase was associated with
increasing probability of DRT below the median (p for trend=
0.035). The highest tertile of DRT was associated with UFR
below the mean value (i.e., 9.2 mL/kg/h) in multinomial logistic regression having the lowest DRT tertile as reference.
DRT was significantly lower in patients with UFR >13 mL/
kg/h than in patients with UFR 10–13 or <10 mL/kg/h. Conclusion: DRT is inversely associated with UFR in CHD patients. Whether a high UFR should be recommended to reduce the DRT needs to be elucidated through an adequate
prospective randomized study.
KW - Hemodialysis · Time of recovery · Ultrafiltration rate · Dialysate sodium · Dialysate temperature
KW - Hemodialysis · Time of recovery · Ultrafiltration rate · Dialysate sodium · Dialysate temperature
UR - http://hdl.handle.net/10807/135644
U2 - 10.1159/000492919
DO - 10.1159/000492919
M3 - Article
SN - 0253-5068
SP - 45
EP - 51
JO - Blood Purification
JF - Blood Purification
ER -