TY - JOUR
T1 - Reconstructing ancient mitochondrial DNA links between Africa and Europe
AU - Cerezo, María
AU - Achilli, Alessandro
AU - Olivieri, Anna
AU - Perego, Ugo A.
AU - Gómez-Carballa, Alberto
AU - Brisighelli, Francesca
AU - Lancioni, Hovirag
AU - Woodward, Scott R.
AU - López-Soto, Manuel
AU - Carracedo, Ángel
AU - Capelli, Cristian
AU - Torroni, Antonio
AU - Salas, Antonio
PY - 2012
Y1 - 2012
N2 - Mitochondrial DNA (mtDNA) lineages of macro-haplogroup L (excluding the derived L3 branches M and N) represent the majority of the typical sub-Saharan mtDNA variability. In Europe, these mtDNAs account for <1% of the total but, when analyzed at the level of control region, they show no signals of having evolved within the European continent, an observation that is compatible with a recent arrival from the African continent. To further evaluate this issue, we analyzed 69 mitochondrial genomes belonging to various L sublineages from a wide range of European populations. Phylogeographic analyses showed that ~65% of the European L lineages most likely arrived in rather recent historical times, including the Romanization period, the Arab conquest of the Iberian Peninsula and Sicily, and during the period of the Atlantic slave trade. However, the remaining 35% of L mtDNAs form European-specific subclades, revealing that there was gene flow from sub-Saharan Africa toward Europe as early as 11,000 yr ago
AB - Mitochondrial DNA (mtDNA) lineages of macro-haplogroup L (excluding the derived L3 branches M and N) represent the majority of the typical sub-Saharan mtDNA variability. In Europe, these mtDNAs account for <1% of the total but, when analyzed at the level of control region, they show no signals of having evolved within the European continent, an observation that is compatible with a recent arrival from the African continent. To further evaluate this issue, we analyzed 69 mitochondrial genomes belonging to various L sublineages from a wide range of European populations. Phylogeographic analyses showed that ~65% of the European L lineages most likely arrived in rather recent historical times, including the Romanization period, the Arab conquest of the Iberian Peninsula and Sicily, and during the period of the Atlantic slave trade. However, the remaining 35% of L mtDNAs form European-specific subclades, revealing that there was gene flow from sub-Saharan Africa toward Europe as early as 11,000 yr ago
KW - mtDNA
KW - mtDNA
UR - http://hdl.handle.net/10807/42499
U2 - 10.1101/gr.134452.111
DO - 10.1101/gr.134452.111
M3 - Article
SN - 1088-9051
VL - 22
SP - 821
EP - 826
JO - Genome Research
JF - Genome Research
ER -