Reconstitution of aluminium and iron core in horse spleen apoferritin

Gabriele Ciasca, M Chiarpotto, G Campi, B Bocca, M Rodio, A Pino, A Ricci, N Poccia, C Rossi, A Alimonti, H Amenitsch, P Sole, A. Bianconi

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

17 Citazioni (Scopus)

Abstract

This study investigates the uptake of iron and aluminium by apoferritin. In particular, we provide the first evidence that apoferritin is able to bind in vitro the physiological form of aluminium, Al(OH)4 −, to reach an Al/Fe atomic ratio of about 0.15. Mass spectrometry analysis shows that the Al content increases linearly as a function of Al concentration in solution. These findings provide a better understanding of the Al uptake in vivo, confirming that the metal content of ferritin depends on the metal bio-availability.
Lingua originaleEnglish
pagine (da-a)6149-6155
Numero di pagine7
RivistaJournal of Nanoparticle Research
Volume13
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • Aluminium Metal toxicity Ferritin SAXS ICP-MS Nanomedicine

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