Reconstitution of aluminium and iron core in horse spleen apoferritin

Gabriele Ciasca; M Chiarpotto; G Campi; B Bocca; M Rodio; A Pino; A Ricci; N Poccia; C Rossi; A Alimonti; H Amenitsch; P Sole; A. Bianconi

doi:10.1007/s11051-011-0294-2

Reconstitution of aluminium and iron core in horse spleen apoferritin

Gabriele Ciasca, M Chiarpotto, G Campi, B Bocca, M Rodio, A Pino, A Ricci, N Poccia, C Rossi, A Alimonti, H Amenitsch, P Sole, A. Bianconi

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

18 Citazioni (Scopus)

Abstract

This study investigates the uptake of iron and aluminium by apoferritin. In particular, we provide the first evidence that apoferritin is able to bind in vitro the physiological form of aluminium, Al(OH)4 −, to reach an Al/Fe atomic ratio of about 0.15. Mass spectrometry analysis shows that the Al content increases linearly as a function of Al concentration in solution. These findings provide a better understanding of the Al uptake in vivo, confirming that the metal content of ferritin depends on the metal bio-availability.

Lingua originale	English
pagine (da-a)	6149-6155
Numero di pagine	7
Rivista	Journal of Nanoparticle Research
Volume	13
DOI	https://doi.org/10.1007/s11051-011-0294-2
Stato di pubblicazione	Pubblicato - 2011

Keywords

Aluminium Metal toxicity Ferritin SAXS ICP-MS Nanomedicine

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10.1007/s11051-011-0294-2

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abstract = "This study investigates the uptake of iron and aluminium by apoferritin. In particular, we provide the first evidence that apoferritin is able to bind in vitro the physiological form of aluminium, Al(OH)4 −, to reach an Al/Fe atomic ratio of about 0.15. Mass spectrometry analysis shows that the Al content increases linearly as a function of Al concentration in solution. These findings provide a better understanding of the Al uptake in vivo, confirming that the metal content of ferritin depends on the metal bio-availability.",

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T1 - Reconstitution of aluminium and iron core in horse spleen apoferritin

AU - Ciasca, Gabriele

AU - Chiarpotto, M

AU - Campi, G

AU - Bocca, B

AU - Rodio, M

AU - Pino, A

AU - Ricci, A

AU - Poccia, N

AU - Rossi, C

AU - Alimonti, A

AU - Amenitsch, H

AU - Sole, P

AU - Bianconi, A.

PY - 2011

Y1 - 2011

N2 - This study investigates the uptake of iron and aluminium by apoferritin. In particular, we provide the first evidence that apoferritin is able to bind in vitro the physiological form of aluminium, Al(OH)4 −, to reach an Al/Fe atomic ratio of about 0.15. Mass spectrometry analysis shows that the Al content increases linearly as a function of Al concentration in solution. These findings provide a better understanding of the Al uptake in vivo, confirming that the metal content of ferritin depends on the metal bio-availability.

AB - This study investigates the uptake of iron and aluminium by apoferritin. In particular, we provide the first evidence that apoferritin is able to bind in vitro the physiological form of aluminium, Al(OH)4 −, to reach an Al/Fe atomic ratio of about 0.15. Mass spectrometry analysis shows that the Al content increases linearly as a function of Al concentration in solution. These findings provide a better understanding of the Al uptake in vivo, confirming that the metal content of ferritin depends on the metal bio-availability.

KW - Aluminium Metal toxicity Ferritin SAXS ICP-MS Nanomedicine

UR - http://hdl.handle.net/10807/43072

U2 - 10.1007/s11051-011-0294-2

DO - 10.1007/s11051-011-0294-2

M3 - Article

VL - 13

SP - 6149

EP - 6155

JO - Journal of Nanoparticle Research

JF - Journal of Nanoparticle Research

SN - 1388-0764

ER -

Reconstitution of aluminium and iron core in horse spleen apoferritin

Abstract

Keywords

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