Reappraisal of the clinical pharmacology of low-dose aspirin by comparing novel direct and traditional indirect biomarkers of drug action

Carlo Patrono, P. Patrignani, S. Tacconelli, E. Piazuelo, L. Di Francesco, M. Dovizio, C. Sostres, E. Marcantoni, P. Guillem-Llobat, P. Del Boccio, M. Zucchelli, A. Lanas

Risultato della ricerca: Contributo in rivistaArticolo in rivista

58 Citazioni (Scopus)

Abstract

Even though the acetylation of platelet cyclooxygenase (COX)-1 at serine-529 is the direct mechanism of action of low-dose aspirin, its antiplatelet effect has been characterized using indirect indexes of COX-1 activity.
Lingua originaleEnglish
pagine (da-a)1320-1330
Numero di pagine11
RivistaJournal of Thrombosis and Haemostasis
Volume12
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • 11-dehydro-thromboxane B2
  • acetylsalicylic acid
  • antiplatelet drugs
  • cyclooxygenase-1
  • proteomics
  • thromboxane A2

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