Real-world approach to actinic keratosis management: practical treatment algorithm for office-based dermatology

Ketty Peris, Iris Zalaudek, Thomas Dirschka, Girish Gupta, Giuseppe Micali, Eggert Stockfleth, Nicole Basset-Séguin, Véronique Del Marmol, Reinhard Dummer, Gregor B. E. Jemec, Josep Malvehy, Susana Puig, Alexander J. Stratigos, Giovanni Pellacani

Risultato della ricerca: Contributo in rivistaArticolo in rivista

39 Citazioni (Scopus)

Abstract

Actinic keratosis (AK) is a chronic skin disease in which multiple clinical and subclinical lesions co-exist across large areas of sun-exposed skin, resulting in field cancerisation. Lesions require treatment because of their potential to transform into invasive squamous cell carcinoma. This article aims to provide office-based dermatologists and general practitioners with simple guidance on AK treatment in daily clinical practice to supplement existing evidence-based guidelines. Novel aspects of the proposed treatment algorithm include differentiating patients according to whether they have isolated scattered lesions, lesions clustered in small areas or large affected fields without reference to specific absolute numbers of lesions. Recognising that complete lesion clearance is rarely achieved in real-life practice and that AK is a chronic disease, the suggested treatment goals are to reduce the number of lesions, to achieve long-term disease control and to prevent disease progression to invasive squamous cell carcinoma. In the clinical setting, physicians should select AK treatments based on local availability, and the presentation and needs of their patients. The proposed AK treatment algorithm is easy-to-use and has high practical relevance for real-life, office-based dermatology.
Lingua originaleEnglish
pagine (da-a)1-12
Numero di pagine12
RivistaTHE JOURNAL OF DERMATOLOGICAL TREATMENT
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • 2708
  • 5-fluorouracil
  • Diclofenac
  • field cancerisation
  • imiquimod
  • ingenol mebutate
  • photodynamic therapy

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