Rate, correlates and outcomes of repeat pregnancy in HIV-infected women

Enrica Tamburrini; M. Floridia; G. Masuelli; P. Martinelli; A. Spinillo; G. Liuzzi; A. Vimercati; S. Alberico; A. Maccabruni; C. Pinnetti; V. Frisina; S. Dalzero; M. Ravizza; F. Mori; P. Ortolani; E. R. Dalle Nogare; F. Di Lorenzo; G. Sterrantino; M. Meli; S. Polemi; J. Nocentini; M. Baldini; G. Montorzi; M. Mazzetti; P. Rogasi; B. Borchi; F. Vichi; B. Del Pin; E. Pinter; E. Anzalone; R. Marocco; C. Mastroianni; V. S. Mercurio; A. Carocci; E. Grilli; M. Zaramella; B. Mariani; G. Natalini Raponi; G. Guaraldi; G. Nardini; C. Stentarelli; B. Beghetto; A. M. Degli Antoni; A. Molinari; M. P. Crisalli; A. Donisi; M. Piepoli; V. Cerri; G. Zuccotti; V. Giacomet; S. Coletto; F. Di Nello; C. Madia; G. Placido; A. Vivarelli; P. Castelli; F. Savalli; V. Portelli; F. Sabbatini; D. Francisci; L. Bernini; P. Grossi; L. Rizzi; G. Maso; M. Airoud; G. Soppelsa; A. Meloni; M. Dedoni; C. Cuboni; F. Ortu; P. Piano; A. Citernesi; I. Bordoni Vicini; K. Luzi; M. Roccio; A. Miccolis; A. De Gennaro; B. Guerra; F. Cervi; G. Simonazzi; E. Margarito; M. G. Capretti; C. Marsico; G. Faldella; M. Sansone; A. Agangi; A. Capone; M. Maruotti; C. Tibaldi; L. Trentini; T. Todros; I. Cetin; T. Brambilla; V. Savasi; C. Personeni; C. Giaquinto; M. Fiscon; E. Rubino; A. Bucceri; R. Matrone; G. Scaravelli; O. Genovese; C. Cafforio; V. Tozzi; P. Massetti; A. M. Casadei; A. F. Cavaliere; M. Cellini; G. Castelli Gattinara; A. M. Marconi; V. Sacchi; M. Ierardi; C. Polizzi; A. Mattei; M. F. Pirillo; R. Amici; C. M. Galluzzo; S. Donnini; S. Baroncelli; P. Villani; M. Cusato; A. Cerioli; M. De Martino; P. Mastroiacovo; F. Parazzini; S. Vella

doi:10.1111/hiv.12473

Rate, correlates and outcomes of repeat pregnancy in HIV-infected women

Enrica Tamburrini, M. Floridia, G. Masuelli, P. Martinelli, A. Spinillo, G. Liuzzi, A. Vimercati, S. Alberico, A. Maccabruni, C. Pinnetti, V. Frisina, S. Dalzero, M. Ravizza, F. Mori, P. Ortolani, E. R. Dalle Nogare, F. Di Lorenzo, G. Sterrantino, M. Meli, S. PolemiJ. Nocentini, M. Baldini, G. Montorzi, M. Mazzetti, P. Rogasi, B. Borchi, F. Vichi, B. Del Pin, E. Pinter, E. Anzalone, R. Marocco, C. Mastroianni, V. S. Mercurio, A. Carocci, E. Grilli, M. Zaramella, B. Mariani, G. Natalini Raponi, G. Guaraldi, G. Nardini, C. Stentarelli, B. Beghetto, A. M. Degli Antoni, A. Molinari, M. P. Crisalli, A. Donisi, M. Piepoli, V. Cerri, G. Zuccotti, V. Giacomet, S. Coletto, F. Di Nello, C. Madia, G. Placido, A. Vivarelli, P. Castelli, F. Savalli, V. Portelli, F. Sabbatini, D. Francisci, L. Bernini, P. Grossi, L. Rizzi, G. Maso, M. Airoud, G. Soppelsa, A. Meloni, M. Dedoni, C. Cuboni, F. Ortu, P. Piano, A. Citernesi, I. Bordoni Vicini, K. Luzi, M. Roccio, A. Miccolis, A. De Gennaro, B. Guerra, F. Cervi, G. Simonazzi, E. Margarito, M. G. Capretti, C. Marsico, G. Faldella, M. Sansone, A. Agangi, A. Capone, M. Maruotti, C. Tibaldi, L. Trentini, T. Todros, I. Cetin, T. Brambilla, V. Savasi, C. Personeni, C. Giaquinto, M. Fiscon, E. Rubino, A. Bucceri, R. Matrone, G. Scaravelli, O. Genovese, C. Cafforio, V. Tozzi, P. Massetti, A. M. Casadei, A. F. Cavaliere, M. Cellini, G. Castelli Gattinara, A. M. Marconi, V. Sacchi, M. Ierardi, C. Polizzi, A. Mattei, M. F. Pirillo, R. Amici, C. M. Galluzzo, S. Donnini, S. Baroncelli, P. Villani, M. Cusato, A. Cerioli, M. De Martino, P. Mastroiacovo, F. Parazzini, S. Vella

Risultato della ricerca: Contributo in rivista › Articolo in rivista

3 Citazioni (Scopus)

Abstract

Objectives: The aim of the study was to assess the rate, determinants, and outcomes of repeat pregnancies in women with HIV infection. Methods: Data from a national study of pregnant women with HIV infection were used. Main outcomes were preterm delivery, low birth weight, CD4 cell count and HIV plasma viral load. Results: The rate of repeat pregnancy among 3007 women was 16.2%. Women with a repeat pregnancy were on average younger than those with a single pregnancy (median age 30 vs. 33 years, respectively), more recently diagnosed with HIV infection (median time since diagnosis 25 vs. 51 months, respectively), and more frequently of foreign origin [odds ratio (OR) 1.36; 95% confidence interval (CI) 1.10-1.68], diagnosed with HIV infection in the current pregnancy (OR: 1.69; 95% CI: 1.35-2.11), and at their first pregnancy (OR: 1.33; 95% CI: 1.06-1.66). In women with sequential pregnancies, compared with the first pregnancy, several outcomes showed a significant improvement in the second pregnancy, with a higher rate of antiretroviral treatment at conception (39.0 vs. 65.4%, respectively), better median maternal weight at the start of pregnancy (60 vs. 61 kg, respectively), a higher rate of end-of-pregnancy undetectable HIV RNA (60.7 vs. 71.6%, respectively), a higher median birth weight (2815 vs. 2885 g, respectively), lower rates of preterm delivery (23.0 vs. 17.7%, respectively) and of low birth weight (23.4 vs. 15.4%, respectively), and a higher median CD4 cell count (+47 cells/μL), with almost no clinical progression to Centers for Disease Control and Prevention stage C (CDC-C) HIV disease (0.3%). The second pregnancy was significantly more likely to end in voluntary termination than the first pregnancy (11.4 vs. 6.1%, respectively). Conclusions: Younger and foreign women were more likely to have a repeat pregnancy; in women with sequential pregnancies, the second pregnancy was characterized by a significant improvement in several outcomes, suggesting that women with HIV infection who desire multiple children may proceed safely and confidently with subsequent pregnancies.

Lingua originale	English
pagine (da-a)	N/A-N/A
Rivista	HIV Medicine
Volume	2017
DOI	https://doi.org/10.1111/hiv.12473
Stato di pubblicazione	Pubblicato - 2016

Keywords

Birth weight
HIV
HIV RNA
Health Policy
Infectious Diseases
Pharmacology (medical)
Pregnancy
Preterm delivery

Accesso al documento

10.1111/hiv.12473

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Tamburrini, E., Floridia, M., Masuelli, G., Martinelli, P., Spinillo, A., Liuzzi, G., Vimercati, A., Alberico, S., Maccabruni, A., Pinnetti, C., Frisina, V., Dalzero, S., Ravizza, M., Mori, F., Ortolani, P., Dalle Nogare, E. R., Di Lorenzo, F., Sterrantino, G., Meli, M., ... Vella, S. (2016). Rate, correlates and outcomes of repeat pregnancy in HIV-infected women. HIV Medicine, 2017, N/A-N/A. https://doi.org/10.1111/hiv.12473

Tamburrini, Enrica ; Floridia, M. ; Masuelli, G. ; Martinelli, P. ; Spinillo, A. ; Liuzzi, G. ; Vimercati, A. ; Alberico, S. ; Maccabruni, A. ; Pinnetti, C. ; Frisina, V. ; Dalzero, S. ; Ravizza, M. ; Mori, F. ; Ortolani, P. ; Dalle Nogare, E. R. ; Di Lorenzo, F. ; Sterrantino, G. ; Meli, M. ; Polemi, S. ; Nocentini, J. ; Baldini, M. ; Montorzi, G. ; Mazzetti, M. ; Rogasi, P. ; Borchi, B. ; Vichi, F. ; Del Pin, B. ; Pinter, E. ; Anzalone, E. ; Marocco, R. ; Mastroianni, C. ; Mercurio, V. S. ; Carocci, A. ; Grilli, E. ; Zaramella, M. ; Mariani, B. ; Natalini Raponi, G. ; Guaraldi, G. ; Nardini, G. ; Stentarelli, C. ; Beghetto, B. ; Degli Antoni, A. M. ; Molinari, A. ; Crisalli, M. P. ; Donisi, A. ; Piepoli, M. ; Cerri, V. ; Zuccotti, G. ; Giacomet, V. ; Coletto, S. ; Di Nello, F. ; Madia, C. ; Placido, G. ; Vivarelli, A. ; Castelli, P. ; Savalli, F. ; Portelli, V. ; Sabbatini, F. ; Francisci, D. ; Bernini, L. ; Grossi, P. ; Rizzi, L. ; Maso, G. ; Airoud, M. ; Soppelsa, G. ; Meloni, A. ; Dedoni, M. ; Cuboni, C. ; Ortu, F. ; Piano, P. ; Citernesi, A. ; Bordoni Vicini, I. ; Luzi, K. ; Roccio, M. ; Miccolis, A. ; De Gennaro, A. ; Guerra, B. ; Cervi, F. ; Simonazzi, G. ; Margarito, E. ; Capretti, M. G. ; Marsico, C. ; Faldella, G. ; Sansone, M. ; Agangi, A. ; Capone, A. ; Maruotti, M. ; Tibaldi, C. ; Trentini, L. ; Todros, T. ; Cetin, I. ; Brambilla, T. ; Savasi, V. ; Personeni, C. ; Giaquinto, C. ; Fiscon, M. ; Rubino, E. ; Bucceri, A. ; Matrone, R. ; Scaravelli, G. ; Genovese, O. ; Cafforio, C. ; Tozzi, V. ; Massetti, P. ; Casadei, A. M. ; Cavaliere, A. F. ; Cellini, M. ; Castelli Gattinara, G. ; Marconi, A. M. ; Sacchi, V. ; Ierardi, M. ; Polizzi, C. ; Mattei, A. ; Pirillo, M. F. ; Amici, R. ; Galluzzo, C. M. ; Donnini, S. ; Baroncelli, S. ; Villani, P. ; Cusato, M. ; Cerioli, A. ; De Martino, M. ; Mastroiacovo, P. ; Parazzini, F. ; Vella, S. / Rate, correlates and outcomes of repeat pregnancy in HIV-infected women. In: HIV Medicine. 2016 ; Vol. 2017. pagg. N/A-N/A.

@article{7e274c3899de4c1fa685d8ec2c9ad1b4,

title = "Rate, correlates and outcomes of repeat pregnancy in HIV-infected women",

abstract = "Objectives: The aim of the study was to assess the rate, determinants, and outcomes of repeat pregnancies in women with HIV infection. Methods: Data from a national study of pregnant women with HIV infection were used. Main outcomes were preterm delivery, low birth weight, CD4 cell count and HIV plasma viral load. Results: The rate of repeat pregnancy among 3007 women was 16.2%. Women with a repeat pregnancy were on average younger than those with a single pregnancy (median age 30 vs. 33 years, respectively), more recently diagnosed with HIV infection (median time since diagnosis 25 vs. 51 months, respectively), and more frequently of foreign origin [odds ratio (OR) 1.36; 95% confidence interval (CI) 1.10-1.68], diagnosed with HIV infection in the current pregnancy (OR: 1.69; 95% CI: 1.35-2.11), and at their first pregnancy (OR: 1.33; 95% CI: 1.06-1.66). In women with sequential pregnancies, compared with the first pregnancy, several outcomes showed a significant improvement in the second pregnancy, with a higher rate of antiretroviral treatment at conception (39.0 vs. 65.4%, respectively), better median maternal weight at the start of pregnancy (60 vs. 61 kg, respectively), a higher rate of end-of-pregnancy undetectable HIV RNA (60.7 vs. 71.6%, respectively), a higher median birth weight (2815 vs. 2885 g, respectively), lower rates of preterm delivery (23.0 vs. 17.7%, respectively) and of low birth weight (23.4 vs. 15.4%, respectively), and a higher median CD4 cell count (+47 cells/μL), with almost no clinical progression to Centers for Disease Control and Prevention stage C (CDC-C) HIV disease (0.3%). The second pregnancy was significantly more likely to end in voluntary termination than the first pregnancy (11.4 vs. 6.1%, respectively). Conclusions: Younger and foreign women were more likely to have a repeat pregnancy; in women with sequential pregnancies, the second pregnancy was characterized by a significant improvement in several outcomes, suggesting that women with HIV infection who desire multiple children may proceed safely and confidently with subsequent pregnancies.",

keywords = "Birth weight, HIV, HIV RNA, Health Policy, Infectious Diseases, Pharmacology (medical), Pregnancy, Preterm delivery, Birth weight, HIV, HIV RNA, Health Policy, Infectious Diseases, Pharmacology (medical), Pregnancy, Preterm delivery",

author = "Enrica Tamburrini and M. Floridia and G. Masuelli and P. Martinelli and A. Spinillo and G. Liuzzi and A. Vimercati and S. Alberico and A. Maccabruni and C. Pinnetti and V. Frisina and S. Dalzero and M. Ravizza and F. Mori and P. Ortolani and {Dalle Nogare}, {E. R.} and {Di Lorenzo}, F. and G. Sterrantino and M. Meli and S. Polemi and J. Nocentini and M. Baldini and G. Montorzi and M. Mazzetti and P. Rogasi and B. Borchi and F. Vichi and {Del Pin}, B. and E. Pinter and E. Anzalone and R. Marocco and C. Mastroianni and Mercurio, {V. S.} and A. Carocci and E. Grilli and M. Zaramella and B. Mariani and {Natalini Raponi}, G. and G. Guaraldi and G. Nardini and C. Stentarelli and B. Beghetto and {Degli Antoni}, {A. M.} and A. Molinari and Crisalli, {M. P.} and A. Donisi and M. Piepoli and V. Cerri and G. Zuccotti and V. Giacomet and S. Coletto and {Di Nello}, F. and C. Madia and G. Placido and A. Vivarelli and P. Castelli and F. Savalli and V. Portelli and F. Sabbatini and D. Francisci and L. Bernini and P. Grossi and L. Rizzi and G. Maso and M. Airoud and G. Soppelsa and A. Meloni and M. Dedoni and C. Cuboni and F. Ortu and P. Piano and A. Citernesi and {Bordoni Vicini}, I. and K. Luzi and M. Roccio and A. Miccolis and {De Gennaro}, A. and B. Guerra and F. Cervi and G. Simonazzi and E. Margarito and Capretti, {M. G.} and C. Marsico and G. Faldella and M. Sansone and A. Agangi and A. Capone and M. Maruotti and C. Tibaldi and L. Trentini and T. Todros and I. Cetin and T. Brambilla and V. Savasi and C. Personeni and C. Giaquinto and M. Fiscon and E. Rubino and A. Bucceri and R. Matrone and G. Scaravelli and O. Genovese and C. Cafforio and V. Tozzi and P. Massetti and Casadei, {A. M.} and Cavaliere, {A. F.} and M. Cellini and {Castelli Gattinara}, G. and Marconi, {A. M.} and V. Sacchi and M. Ierardi and C. Polizzi and A. Mattei and Pirillo, {M. F.} and R. Amici and Galluzzo, {C. M.} and S. Donnini and S. Baroncelli and P. Villani and M. Cusato and A. Cerioli and {De Martino}, M. and P. Mastroiacovo and F. Parazzini and S. Vella",

year = "2016",

doi = "10.1111/hiv.12473",

language = "English",

volume = "2017",

pages = "N/A--N/A",

journal = "HIV Medicine",

issn = "1464-2662",

publisher = "Blackwell Science",

}

Tamburrini, E, Floridia, M, Masuelli, G, Martinelli, P, Spinillo, A, Liuzzi, G, Vimercati, A, Alberico, S, Maccabruni, A, Pinnetti, C, Frisina, V, Dalzero, S, Ravizza, M, Mori, F, Ortolani, P, Dalle Nogare, ER, Di Lorenzo, F, Sterrantino, G, Meli, M, Polemi, S, Nocentini, J, Baldini, M, Montorzi, G, Mazzetti, M, Rogasi, P, Borchi, B, Vichi, F, Del Pin, B, Pinter, E, Anzalone, E, Marocco, R, Mastroianni, C, Mercurio, VS, Carocci, A, Grilli, E, Zaramella, M, Mariani, B, Natalini Raponi, G, Guaraldi, G, Nardini, G, Stentarelli, C, Beghetto, B, Degli Antoni, AM, Molinari, A, Crisalli, MP, Donisi, A, Piepoli, M, Cerri, V, Zuccotti, G, Giacomet, V, Coletto, S, Di Nello, F, Madia, C, Placido, G, Vivarelli, A, Castelli, P, Savalli, F, Portelli, V, Sabbatini, F, Francisci, D, Bernini, L, Grossi, P, Rizzi, L, Maso, G, Airoud, M, Soppelsa, G, Meloni, A, Dedoni, M, Cuboni, C, Ortu, F, Piano, P, Citernesi, A, Bordoni Vicini, I, Luzi, K, Roccio, M, Miccolis, A, De Gennaro, A, Guerra, B, Cervi, F, Simonazzi, G, Margarito, E, Capretti, MG, Marsico, C, Faldella, G, Sansone, M, Agangi, A, Capone, A, Maruotti, M, Tibaldi, C, Trentini, L, Todros, T, Cetin, I, Brambilla, T, Savasi, V, Personeni, C, Giaquinto, C, Fiscon, M, Rubino, E, Bucceri, A, Matrone, R, Scaravelli, G, Genovese, O, Cafforio, C, Tozzi, V, Massetti, P, Casadei, AM, Cavaliere, AF, Cellini, M, Castelli Gattinara, G, Marconi, AM, Sacchi, V, Ierardi, M, Polizzi, C, Mattei, A, Pirillo, MF, Amici, R, Galluzzo, CM, Donnini, S, Baroncelli, S, Villani, P, Cusato, M, Cerioli, A, De Martino, M, Mastroiacovo, P, Parazzini, F & Vella, S 2016, 'Rate, correlates and outcomes of repeat pregnancy in HIV-infected women', HIV Medicine, vol. 2017, pagg. N/A-N/A. https://doi.org/10.1111/hiv.12473

Rate, correlates and outcomes of repeat pregnancy in HIV-infected women. / Tamburrini, Enrica; Floridia, M.; Masuelli, G.; Martinelli, P.; Spinillo, A.; Liuzzi, G.; Vimercati, A.; Alberico, S.; Maccabruni, A.; Pinnetti, C.; Frisina, V.; Dalzero, S.; Ravizza, M.; Mori, F.; Ortolani, P.; Dalle Nogare, E. R.; Di Lorenzo, F.; Sterrantino, G.; Meli, M.; Polemi, S.; Nocentini, J.; Baldini, M.; Montorzi, G.; Mazzetti, M.; Rogasi, P.; Borchi, B.; Vichi, F.; Del Pin, B.; Pinter, E.; Anzalone, E.; Marocco, R.; Mastroianni, C.; Mercurio, V. S.; Carocci, A.; Grilli, E.; Zaramella, M.; Mariani, B.; Natalini Raponi, G.; Guaraldi, G.; Nardini, G.; Stentarelli, C.; Beghetto, B.; Degli Antoni, A. M.; Molinari, A.; Crisalli, M. P.; Donisi, A.; Piepoli, M.; Cerri, V.; Zuccotti, G.; Giacomet, V.; Coletto, S.; Di Nello, F.; Madia, C.; Placido, G.; Vivarelli, A.; Castelli, P.; Savalli, F.; Portelli, V.; Sabbatini, F.; Francisci, D.; Bernini, L.; Grossi, P.; Rizzi, L.; Maso, G.; Airoud, M.; Soppelsa, G.; Meloni, A.; Dedoni, M.; Cuboni, C.; Ortu, F.; Piano, P.; Citernesi, A.; Bordoni Vicini, I.; Luzi, K.; Roccio, M.; Miccolis, A.; De Gennaro, A.; Guerra, B.; Cervi, F.; Simonazzi, G.; Margarito, E.; Capretti, M. G.; Marsico, C.; Faldella, G.; Sansone, M.; Agangi, A.; Capone, A.; Maruotti, M.; Tibaldi, C.; Trentini, L.; Todros, T.; Cetin, I.; Brambilla, T.; Savasi, V.; Personeni, C.; Giaquinto, C.; Fiscon, M.; Rubino, E.; Bucceri, A.; Matrone, R.; Scaravelli, G.; Genovese, O.; Cafforio, C.; Tozzi, V.; Massetti, P.; Casadei, A. M.; Cavaliere, A. F.; Cellini, M.; Castelli Gattinara, G.; Marconi, A. M.; Sacchi, V.; Ierardi, M.; Polizzi, C.; Mattei, A.; Pirillo, M. F.; Amici, R.; Galluzzo, C. M.; Donnini, S.; Baroncelli, S.; Villani, P.; Cusato, M.; Cerioli, A.; De Martino, M.; Mastroiacovo, P.; Parazzini, F.; Vella, S.

In: HIV Medicine, Vol. 2017, 2016, pag. N/A-N/A.

Risultato della ricerca: Contributo in rivista › Articolo in rivista

TY - JOUR

T1 - Rate, correlates and outcomes of repeat pregnancy in HIV-infected women

AU - Tamburrini, Enrica

AU - Floridia, M.

AU - Masuelli, G.

AU - Martinelli, P.

AU - Spinillo, A.

AU - Liuzzi, G.

AU - Vimercati, A.

AU - Alberico, S.

AU - Maccabruni, A.

AU - Pinnetti, C.

AU - Frisina, V.

AU - Dalzero, S.

AU - Ravizza, M.

AU - Mori, F.

AU - Ortolani, P.

AU - Dalle Nogare, E. R.

AU - Di Lorenzo, F.

AU - Sterrantino, G.

AU - Meli, M.

AU - Polemi, S.

AU - Nocentini, J.

AU - Baldini, M.

AU - Montorzi, G.

AU - Mazzetti, M.

AU - Rogasi, P.

AU - Borchi, B.

AU - Vichi, F.

AU - Del Pin, B.

AU - Pinter, E.

AU - Anzalone, E.

AU - Marocco, R.

AU - Mastroianni, C.

AU - Mercurio, V. S.

AU - Carocci, A.

AU - Grilli, E.

AU - Zaramella, M.

AU - Mariani, B.

AU - Natalini Raponi, G.

AU - Guaraldi, G.

AU - Nardini, G.

AU - Stentarelli, C.

AU - Beghetto, B.

AU - Degli Antoni, A. M.

AU - Molinari, A.

AU - Crisalli, M. P.

AU - Donisi, A.

AU - Piepoli, M.

AU - Cerri, V.

AU - Zuccotti, G.

AU - Giacomet, V.

AU - Coletto, S.

AU - Di Nello, F.

AU - Madia, C.

AU - Placido, G.

AU - Vivarelli, A.

AU - Castelli, P.

AU - Savalli, F.

AU - Portelli, V.

AU - Sabbatini, F.

AU - Francisci, D.

AU - Bernini, L.

AU - Grossi, P.

AU - Rizzi, L.

AU - Maso, G.

AU - Airoud, M.

AU - Soppelsa, G.

AU - Meloni, A.

AU - Dedoni, M.

AU - Cuboni, C.

AU - Ortu, F.

AU - Piano, P.

AU - Citernesi, A.

AU - Bordoni Vicini, I.

AU - Luzi, K.

AU - Roccio, M.

AU - Miccolis, A.

AU - De Gennaro, A.

AU - Guerra, B.

AU - Cervi, F.

AU - Simonazzi, G.

AU - Margarito, E.

AU - Capretti, M. G.

AU - Marsico, C.

AU - Faldella, G.

AU - Sansone, M.

AU - Agangi, A.

AU - Capone, A.

AU - Maruotti, M.

AU - Tibaldi, C.

AU - Trentini, L.

AU - Todros, T.

AU - Cetin, I.

AU - Brambilla, T.

AU - Savasi, V.

AU - Personeni, C.

AU - Giaquinto, C.

AU - Fiscon, M.

AU - Rubino, E.

AU - Bucceri, A.

AU - Matrone, R.

AU - Scaravelli, G.

AU - Genovese, O.

AU - Cafforio, C.

AU - Tozzi, V.

AU - Massetti, P.

AU - Casadei, A. M.

AU - Cavaliere, A. F.

AU - Cellini, M.

AU - Castelli Gattinara, G.

AU - Marconi, A. M.

AU - Sacchi, V.

AU - Ierardi, M.

AU - Polizzi, C.

AU - Mattei, A.

AU - Pirillo, M. F.

AU - Amici, R.

AU - Galluzzo, C. M.

AU - Donnini, S.

AU - Baroncelli, S.

AU - Villani, P.

AU - Cusato, M.

AU - Cerioli, A.

AU - De Martino, M.

AU - Mastroiacovo, P.

AU - Parazzini, F.

AU - Vella, S.

PY - 2016

Y1 - 2016

N2 - Objectives: The aim of the study was to assess the rate, determinants, and outcomes of repeat pregnancies in women with HIV infection. Methods: Data from a national study of pregnant women with HIV infection were used. Main outcomes were preterm delivery, low birth weight, CD4 cell count and HIV plasma viral load. Results: The rate of repeat pregnancy among 3007 women was 16.2%. Women with a repeat pregnancy were on average younger than those with a single pregnancy (median age 30 vs. 33 years, respectively), more recently diagnosed with HIV infection (median time since diagnosis 25 vs. 51 months, respectively), and more frequently of foreign origin [odds ratio (OR) 1.36; 95% confidence interval (CI) 1.10-1.68], diagnosed with HIV infection in the current pregnancy (OR: 1.69; 95% CI: 1.35-2.11), and at their first pregnancy (OR: 1.33; 95% CI: 1.06-1.66). In women with sequential pregnancies, compared with the first pregnancy, several outcomes showed a significant improvement in the second pregnancy, with a higher rate of antiretroviral treatment at conception (39.0 vs. 65.4%, respectively), better median maternal weight at the start of pregnancy (60 vs. 61 kg, respectively), a higher rate of end-of-pregnancy undetectable HIV RNA (60.7 vs. 71.6%, respectively), a higher median birth weight (2815 vs. 2885 g, respectively), lower rates of preterm delivery (23.0 vs. 17.7%, respectively) and of low birth weight (23.4 vs. 15.4%, respectively), and a higher median CD4 cell count (+47 cells/μL), with almost no clinical progression to Centers for Disease Control and Prevention stage C (CDC-C) HIV disease (0.3%). The second pregnancy was significantly more likely to end in voluntary termination than the first pregnancy (11.4 vs. 6.1%, respectively). Conclusions: Younger and foreign women were more likely to have a repeat pregnancy; in women with sequential pregnancies, the second pregnancy was characterized by a significant improvement in several outcomes, suggesting that women with HIV infection who desire multiple children may proceed safely and confidently with subsequent pregnancies.

AB - Objectives: The aim of the study was to assess the rate, determinants, and outcomes of repeat pregnancies in women with HIV infection. Methods: Data from a national study of pregnant women with HIV infection were used. Main outcomes were preterm delivery, low birth weight, CD4 cell count and HIV plasma viral load. Results: The rate of repeat pregnancy among 3007 women was 16.2%. Women with a repeat pregnancy were on average younger than those with a single pregnancy (median age 30 vs. 33 years, respectively), more recently diagnosed with HIV infection (median time since diagnosis 25 vs. 51 months, respectively), and more frequently of foreign origin [odds ratio (OR) 1.36; 95% confidence interval (CI) 1.10-1.68], diagnosed with HIV infection in the current pregnancy (OR: 1.69; 95% CI: 1.35-2.11), and at their first pregnancy (OR: 1.33; 95% CI: 1.06-1.66). In women with sequential pregnancies, compared with the first pregnancy, several outcomes showed a significant improvement in the second pregnancy, with a higher rate of antiretroviral treatment at conception (39.0 vs. 65.4%, respectively), better median maternal weight at the start of pregnancy (60 vs. 61 kg, respectively), a higher rate of end-of-pregnancy undetectable HIV RNA (60.7 vs. 71.6%, respectively), a higher median birth weight (2815 vs. 2885 g, respectively), lower rates of preterm delivery (23.0 vs. 17.7%, respectively) and of low birth weight (23.4 vs. 15.4%, respectively), and a higher median CD4 cell count (+47 cells/μL), with almost no clinical progression to Centers for Disease Control and Prevention stage C (CDC-C) HIV disease (0.3%). The second pregnancy was significantly more likely to end in voluntary termination than the first pregnancy (11.4 vs. 6.1%, respectively). Conclusions: Younger and foreign women were more likely to have a repeat pregnancy; in women with sequential pregnancies, the second pregnancy was characterized by a significant improvement in several outcomes, suggesting that women with HIV infection who desire multiple children may proceed safely and confidently with subsequent pregnancies.

KW - Birth weight

KW - HIV

KW - HIV RNA

KW - Health Policy

KW - Infectious Diseases

KW - Pharmacology (medical)

KW - Pregnancy

KW - Preterm delivery

KW - Birth weight

KW - HIV

KW - HIV RNA

KW - Health Policy

KW - Infectious Diseases

KW - Pharmacology (medical)

KW - Pregnancy

KW - Preterm delivery

UR - http://hdl.handle.net/10807/95674

UR - http://www.wiley.com/bw/journal.asp?ref=1464-2662

U2 - 10.1111/hiv.12473

DO - 10.1111/hiv.12473

M3 - Article

VL - 2017

SP - N/A-N/A

JO - HIV Medicine

JF - HIV Medicine

SN - 1464-2662

ER -

Rate, correlates and outcomes of repeat pregnancy in HIV-infected women

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