Rare Case of Endoscopic Treatment for Bevacizumab-Related Gastric Perforation in a Patient with Ovarian Cancer

Serena Cappuccio; Benito Marinucci; Vincenzo Bove; Luigi Carlo Turco; Francesco Cosentino; Giovanni Scambia; Guido Costamagna; Ivo Boskoski

doi:10.1159/000508556

Rare Case of Endoscopic Treatment for Bevacizumab-Related Gastric Perforation in a Patient with Ovarian Cancer

Serena Cappuccio, Benito Marinucci, Vincenzo Bove, Luigi Carlo Turco, Francesco Cosentino, Giovanni Scambia, Guido Costamagna, Ivo Boskoski

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

Antiangiogenic chemotherapy is a common treatment option for patients with advanced ovarian cancer (OC) and has been proven to be effective and generally safe. Nevertheless, in rare cases, these drugs can give serious complications such as gastrointestinal perforations that can be even mortal or very difficult to treat and can heavily impact the clinical management. We present a rare case of bevacizumab-induced gastric perforation in a patient with advanced OC occurred during bevacizumab-including chemotherapy in an adjuvant setting. Surgical treatment was not possible due to the frailty of the clinical condition of the patient and the gastric perforation was successfully treated with endoscopic suturing.

Lingua originale	English
pagine (da-a)	54-57
Numero di pagine	4
Rivista	Chemotherapy
Volume	65
DOI	https://doi.org/10.1159/000508556
Stato di pubblicazione	Pubblicato - 2020

Keywords

Adverse events
Bevacizumab
Endoscopic suture
Gastric perforation
Ovarian cancer

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abstract = "Antiangiogenic chemotherapy is a common treatment option for patients with advanced ovarian cancer (OC) and has been proven to be effective and generally safe. Nevertheless, in rare cases, these drugs can give serious complications such as gastrointestinal perforations that can be even mortal or very difficult to treat and can heavily impact the clinical management. We present a rare case of bevacizumab-induced gastric perforation in a patient with advanced OC occurred during bevacizumab-including chemotherapy in an adjuvant setting. Surgical treatment was not possible due to the frailty of the clinical condition of the patient and the gastric perforation was successfully treated with endoscopic suturing.",

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TY - JOUR

T1 - Rare Case of Endoscopic Treatment for Bevacizumab-Related Gastric Perforation in a Patient with Ovarian Cancer

AU - Cappuccio, Serena

AU - Marinucci, Benito

AU - Bove, Vincenzo

AU - Turco, Luigi Carlo

AU - Cosentino, Francesco

AU - Scambia, Giovanni

AU - Costamagna, Guido

AU - Boskoski, Ivo

PY - 2020

Y1 - 2020

N2 - Antiangiogenic chemotherapy is a common treatment option for patients with advanced ovarian cancer (OC) and has been proven to be effective and generally safe. Nevertheless, in rare cases, these drugs can give serious complications such as gastrointestinal perforations that can be even mortal or very difficult to treat and can heavily impact the clinical management. We present a rare case of bevacizumab-induced gastric perforation in a patient with advanced OC occurred during bevacizumab-including chemotherapy in an adjuvant setting. Surgical treatment was not possible due to the frailty of the clinical condition of the patient and the gastric perforation was successfully treated with endoscopic suturing.

AB - Antiangiogenic chemotherapy is a common treatment option for patients with advanced ovarian cancer (OC) and has been proven to be effective and generally safe. Nevertheless, in rare cases, these drugs can give serious complications such as gastrointestinal perforations that can be even mortal or very difficult to treat and can heavily impact the clinical management. We present a rare case of bevacizumab-induced gastric perforation in a patient with advanced OC occurred during bevacizumab-including chemotherapy in an adjuvant setting. Surgical treatment was not possible due to the frailty of the clinical condition of the patient and the gastric perforation was successfully treated with endoscopic suturing.

KW - Adverse events

KW - Bevacizumab

KW - Endoscopic suture

KW - Gastric perforation

KW - Ovarian cancer

KW - Adverse events

KW - Bevacizumab

KW - Endoscopic suture

KW - Gastric perforation

KW - Ovarian cancer

UR - http://hdl.handle.net/10807/221955

U2 - 10.1159/000508556

DO - 10.1159/000508556

M3 - Article

SN - 0009-3157

VL - 65

SP - 54

EP - 57

JO - Chemotherapy

JF - Chemotherapy

ER -

Rare Case of Endoscopic Treatment for Bevacizumab-Related Gastric Perforation in a Patient with Ovarian Cancer

Abstract

Keywords

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