RANTES correlates with inflammatory activity and synaptic excitability in multiple sclerosis

Gaetano Martino, Paolo Maria Rossini, Francesco Mori, Robert Nisticò, Carolina G. Nicoletti, Sara Zagaglia, Georgia Mandolesi, Sonia Piccinin, Gianvito Martino, Annamaria Finardi, Girolama A. Marfia, Roberto Furlan, Diego Centonze

Risultato della ricerca: Contributo in rivistaArticolo in rivista

26 Citazioni (Scopus)

Abstract

Alterations of synaptic transmission induced by inflammatory activity have been linked to the pathogenic mechanisms of multiple sclerosis (MS). Regulated upon activation, normal T-cell expressed, and secreted (RANTES) is a pro-inflammatory chemokine involved in MS pathophysiology, potentially able to regulate glutamate release and plasticity in MS brains, with relevant consequences on the clinical manifestations of the disease.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaMultiple sclerosis (Houndmills, Basingstoke, England)
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • CSF
  • Chemokines
  • LTP
  • TMS
  • glutamate
  • synaptic plasticity

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