Radiotherapy plus GnRH analogue versus high dose bicalutamide: A case control study

Francesco Deodato, Vincenzo Valentini, Anna Rita Alitto, Giovanna Mantini, Milly Buwenge, Giambattista Siepe, Xiao Zhao, Richard K. Valicenti, Maria Ntreta, Silvia Bisello, Alessio G. Morganti, Silvia Cammelli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

1 Citazioni (Scopus)

Abstract

Background/Aim: Radiotherapy (RT) with adjuvant hormone therapy (HT) improves prognosis in prostate cancer (PC) patients. Gonadotrophin-releasing hormone agonist (GnRHa) with luteinizing hormone–releasing hormone (LH-RH) analogues is the standard HT. High-dose antiandrogen therapy also improves survival in patients with locally advanced PC. The aim of this study was to compare the results of patients treated with RT plus GnRHa and patients treated with RT plus bicalutamide. Patients and Methods: Our institutional PC database was used to identify patients treated with definitive or postoperative RT +/- HT which were included in this study. Results: Three hundred and eighteen patients were retrospectively reviewed (median follow-up=56 months). Five-year biochemical relapse-free survival was 85.5% and 88.3% in patients treated with GnRHa and bicalutamide, respectively (p=0.712). Conclusion: Bicalutamide may be offered as an adjuvant treatment to RT in patients who refuse GnRHa because of related side effects. Furthermore, our study justifies randomized trials comparing RT plus GnRHa and RT plus bicalutamide.
Lingua originaleEnglish
pagine (da-a)6373-6378
Numero di pagine6
RivistaAnticancer Research
Volume39
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • Adjuvant hormonal therapy
  • Aged
  • Aged, 80 and over
  • Androgen Antagonists
  • Anilides
  • Antineoplastic Agents, Hormonal
  • Bicalutamide
  • Case-Control Studies
  • Combined Modality Therapy
  • Gonadotrophin-releasing hormone agonist
  • Gonadotropin-Releasing Hormone
  • Humans
  • Male
  • Middle Aged
  • Nitriles
  • Prognosis
  • Prostate neoplasm
  • Prostate-Specific Antigen
  • Prostatic Neoplasms
  • Radiotherapy
  • Retrospective Studies
  • Tosyl Compounds

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