Radiotherapy and concomitant temozolomide during the first and last weeks in high grade gliomas: long-term analysis of a phase II study

Angelo Pompucci, Stefania Manfrida, Filippo De Renzi, Gabriella Colicchio, Giuseppina Apicella, Annunziato Mangiola, Alessandro Fiorentino, Vincenzo Frascino, Giovanna Mantini, Berardino De Bari, Viola Valentini, Carmelo Anile, Numa Cellini, Marinella Balducci, Gr D'Agostino

Risultato della ricerca: Contributo in rivistaArticolo in rivista

13 Citazioni (Scopus)

Abstract

We tested the efficacy and safety of temozolomide (TMZ) when given concomitantly to radiotherapy only in the first and last weeks of treatment to patients affected by high grade gliomas. Conformal radiotherapy (CTV1: tumor bed + residual tumor if present + 1.5 cm, 5,940 cGy, 180 cGy/day; CTV2: oedema, 3,960 cGy, 180 cGy/day) was associated with TMZ, 75 mg/m(2) x 5 days, the first and last weeks of radiotherapy. Adjuvant chemotherapy with TMZ (150 mg/mq daily x 5 days, q28 on the first cycle, 200 mg/mq daily x 5 days, q28 for the following cycles) was given, after chemoradiation, until disease progression or up to 6 cycles. From October 2000 to December 2003, 29 patients (25 GBL, 86.2%; 4 AA, 13.8%) were enrolled in this study. Twenty-two patients (75.8%) received a median 6 cycles of adjuvant chemotherapy with TMZ (range 1-20). Hematological toxicity was absent during concomitant chemoradiation and mild in adjuvant therapy, while neurological toxicity (seizures) was observed only in one case. At a median follow-up of 66 months (range 3-96), median progression-free survival (PFS) was 8 months, with a 1- and 2-year PFS of 46.7 and 28.7%, respectively; median overall survival (OS) time was 21 months, with a 1- and 2-year OS of 69.2 and 42.3%, respectively. In our experience, TMZ proved to be effective even when given only during the first and the last week of radiotherapy, with lower hematological toxicity.
Lingua originaleEnglish
pagine (da-a)95-100
Numero di pagine6
RivistaJournal of Neuro-Oncology
Volume97
DOI
Stato di pubblicazionePubblicato - 2010

Keywords

  • Adult
  • Aged
  • Antineoplastic Agents, Alkylating
  • Brain Neoplasms
  • Combined Modality Therapy
  • Dacarbazine
  • Disease Progression
  • Disease-Free Survival
  • Female
  • Glioblastoma
  • Humans
  • Longitudinal Studies
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Radiotherapy, Conformal
  • Treatment Outcome

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