Radiofrequency ablation for intraductal extension of ampullary adenomatous lesions: proposal for a standardized protocol

Andrea Tringali, Maria Valeria Matteo, Beatrice Orlandini, Federico Barbaro, Vincenzo Perri, Qianqian Zhang, Riccardo Ricci, Guido Costamagna

Risultato della ricerca: Contributo in rivistaArticolo in rivista


Background and study aims Intraductal extension of ampullary adenoma represents a challenging endoscopic issue. Intraductal radiofrequency ablation (RFA) has been recently suggested, but evidence and standardization of this technique are still lacking. This study aimed to provide a long-term evaluation of clinical efficacy and safety of intraductal RFA ablation with a standardized algorithm of treatment. Patients and methods Data were prospectively collected from consecutive patients with intraductal extension of adenomatous ampullary lesions from January 2016 to November 2018. Endpoints of the study were clinical success evaluated on histology results at the last follow-up, technical success, and adverse events assessment. Results Nine patients with intraductal (biliary ± pancreatic) extension of ampullary adenomas were treated with RFA during the study period. Histology on the papillectomy specimen confirmed intraductal involvement with lowgrade dysplasia (LGD) in five cases (56%), high-grade dysplasia (HGD) in three (33%), and HGD with intramucosal adenocarcinoma in one patient (11 %). Additional argon plasma coagulation to ablate the adenoma on the duodenal mucosa was applied in five patients (56%). Technical success was 100 %. One patient (11%) with failed pancreatic stenting, developing acute pancreatitis after RFA, recovered with medical therapy. After a median follow-up of 21 months (IQR 20–31), six patients (67%) achieved clinical success being free of recurrence, whereas one was diagnosed with persistence of adenocarcinoma, one with recurrent HGD, and one with recurrent LGD. Conclusions In our experience, intraductal RFA achieved acceptable results after a 2-year follow-up. Further studies are required to confirm our results and to select those patients most likely to respond.
Lingua originaleEnglish
pagine (da-a)E749-E755
RivistaEndoscopy International Open
Stato di pubblicazionePubblicato - 2021


  • Ampulloma
  • Radio freuency ablation


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