Radiation effects on male fertility

Claudia Marchetti, F. De Felice, F. Marampon, G. Cascialli, L. Muzii, V. Tombolini

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Background: Spermatogenesis is a process of dynamic cell differentiation. Ionizing radiation impairs spermatogenesis, and spermatogonia are more radiosensitive than spermatocytes or spermatids. Consistent with this assumption and due to improvement in tumor curability, nowadays, fertility preservation represents a public health need. Objectives: To discuss radiotherapy-induced risk to male fertility and raise oncologic awareness of male fertility in daily clinical practice. Materials and Methods: PubMed and Clinicaltrials.gov databases were searched for papers in English. Results: We provide an overview of clinical landscape. Four main issues were proposed: (i) spermatogenesis and radiobiological general concepts; (ii) impairment of spermatogenesis; (iii) impairment of testosterone-producing Leydig cells; (iv) clinical radiotherapy evidence in oncology. Conclusion: This review can be useful in daily clinical work and offer some directions for future research.
Lingua originaleEnglish
pagine (da-a)2-7
Numero di pagine6
RivistaAndrology
Volume7
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • fertility
  • late effects
  • oligospermia
  • spermatogonia
  • radiotherapy
  • spermatogenesis
  • radiation

Fingerprint

Entra nei temi di ricerca di 'Radiation effects on male fertility'. Insieme formano una fingerprint unica.

Cita questo