Radial Peripapillary Capillary Plexus Perfusion and Endothelial Dysfunction in Early Post-SARS-CoV-2 Infection

Maria Cristina Savastano, Luca Santoro, Emanuele Crincoli, Claudia Fossataro, Gloria Gambini, Alfonso Savastano, Umberto De Vico, Angelo Santoliquido, Antonio Nesci, Francesco Landi, Stanislao Rizzo

Risultato della ricerca: Contributo in rivistaArticolo in rivista


Background: Endothelial cells damage and thromboinflammation are considered key elements in the generation of organ impairment in patients with COVID-19 disease. The endothelial function is evaluated by measuring flow-mediated dilation (FMD). We aimed to analyze the association between FMD impairment and retinal vascular parameters in early post-COVID-19 patients. 00118-00199Tomography (OCT), OCT Angiography (OCTA) and slit lamp examination were performed. FMD ≤ 7% was considered as pathological. Our primary outcome was to assess potential differences in the radial peripapillary capillary plexus flow index (RPCP-FI) and RPCP density (RPCP-D) values between post-COVID-19 patients with and without FMD impairment. The associations of other retinal vascular parameters with FMD impairment were assessed as secondary endpoints. Results: FMD impairment was detected in 31 patients (37.8%). RPCP-FI (p = 0.047), age (p = 0.048) and prevalence of diabetes (p = 0.046) significantly differed in patients with FMD ≤ 7% in regression analysis. RPCP-FI was linearly correlated with FMD values (R = 0.244, p =0.027). SCT was found to be lower in patients with impaired FMD (p = 0.004), although this difference was only a trend in binary logistic regression output (p = 0.07). Conclusions: Early post-COVID-19 patients showed a higher prevalence of FMD impairment compared to the general population. Age, diabetes and RPCP-FI were independently correlated with the presence of endothelial impairment in the early post-infective period.
Lingua originaleEnglish
pagine (da-a)26-38
Numero di pagine13
Stato di pubblicazionePubblicato - 2022


  • COVID-19
  • OCT angiography
  • SARS-CoV-2
  • diabetes
  • endothelial dysfunction
  • flow-mediated dilation
  • macula
  • retinal vascular layers


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