Quest for Missing Proteins: Update 2015 on Chromosome-Centric Human Proteome Project

Peter Horvatovich*, Emma K. Lundberg, Yu Ju Chen, Ting Yi Sung, Fuchu He, Ec Nice, Robert J Goode, Simon Yu, Shoba Ranganathan, Mark S Baker, Gb Domont, Erika Velasquez, Dong Li, Siqi Liu, Quanhui Wang, Qing Yu He, Rajasree Menon, Yuanfang Guan, Fj Corrales, Victor SeguraJi Casal, A Pascual Montano, Jp Albar, Manuel Fuentes, M Gonzalez Gonzalez, Paula Diez, Nieves Ibarrola, Rosa M Degano, Yassene And Borchers Mohammed, Andrea Urbani, Alessio Soggiu, Tadashi Yamamoto, Ghasem Hosseini Salekdeh, Alexander Archakov, Elena Ponomarenko, Andrey Lisitsa, Cheryl F Lichti, Ekaterina Mostovenko, Roger A Kroes, Melinda Rezeli, Akos Vegvari, Thomas E Fehniger, Rainer Bischoff, Juan Antonio Vizcaino, Eric W Deutsch, Lydie Lane, Carol L Nilsson, Gyorgy Marko Varga, Gilbert S Omenn, Seul Ki Jeong, Jong Sun Lim, Young Ki Paik, William S. Hancock

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo

52 Citazioni (Scopus)

Abstract

This paper summarizes the recent activities of the Chromosome-Centric Human Proteome Project (C-HPP) consortium, which develops new technologies to identify yet-to-be annotated proteins (termed "missing proteins") in biological samples that lack sufficient experimental evidence at the protein level for confident protein identification. The C-HPP also aims to identify new protein forms that may be caused by genetic variability, post-translational modifications, and alternative splicing. Proteogenomic data integration forms the basis of the C-HPP's activities; therefore, we have summarized some of the key approaches and their roles in the project. We present new analytical technologies that improve the chemical space and lower detection limits coupled to bioinformatics tools and some publicly available resources that can be used to improve data analysis or support the development of analytical assays. Most of this paper's content has been compiled from posters, slides, and discussions presented in the series of C-HPP workshops held during 2014. All data (posters, presentations) used are available at the C-HPP Wild (http://c-hpp.webhosting.rug.nl/) and in the Supporting Information.
Lingua originaleInglese
pagine (da-a)3415-3431
Numero di pagine17
RivistaJournal of Proteome Research
Volume14
Numero di pubblicazione9
DOI
Stato di pubblicazionePubblicato - 2015

All Science Journal Classification (ASJC) codes

  • Chimica Generale
  • Biochimica

Keywords

  • Chromosome-Centric Human Proteome Project
  • missing proteins

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