PU.1 and CEBPA expression in acute myeloid leukemia.

Francesco D'Alo'; Annalisa Di Ruscio; Francesco Guidi; Emiliano Fabiani; Mariangela Greco; Carlo Rumi; Stefan Hohaus; Maria Teresa Voso

doi:10.1016/j.leukres.2008.01.007

PU.1 and CEBPA expression in acute myeloid leukemia.

Francesco D'Alo', Annalisa Di Ruscio, Francesco Guidi, Emiliano Fabiani, Mariangela Greco, Carlo Rumi, Stefan Hohaus, Maria Teresa Voso

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

16 Citazioni (Scopus)

Abstract

Alterations of the transcription factors CCAAT/enhancer binding protein alpha (CEBPA) and PU.1 have been described in acute myeloid leukemia (AML). We studied CEBPA and PU.1 mRNA levels by real-time RT-PCR in 109 primary AML samples, compared with normal bone marrow and peripheral blood cells. Low PU.1 levels were observed in monoblastic leukemias, while low CEBPA levels were associated with leukopenia at diagnosis and lack of expression of differentiation antigens CD33 and CD11c. We conclude that down-regulation of CEBPA and PU.1 is not a general feature of primary AML, but appears to be restricted to distinct AML subtypes.

Lingua originale	English
pagine (da-a)	1448-1453
Numero di pagine	6
Rivista	Leukemia Research
DOI	https://doi.org/10.1016/j.leukres.2008.01.007
Stato di pubblicazione	Pubblicato - 2008

Keywords

Acute myeloid leukemia
Prognosis
Transcription factor

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10.1016/j.leukres.2008.01.007

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title = "PU.1 and CEBPA expression in acute myeloid leukemia.",

abstract = "Alterations of the transcription factors CCAAT/enhancer binding protein alpha (CEBPA) and PU.1 have been described in acute myeloid leukemia (AML). We studied CEBPA and PU.1 mRNA levels by real-time RT-PCR in 109 primary AML samples, compared with normal bone marrow and peripheral blood cells. Low PU.1 levels were observed in monoblastic leukemias, while low CEBPA levels were associated with leukopenia at diagnosis and lack of expression of differentiation antigens CD33 and CD11c. We conclude that down-regulation of CEBPA and PU.1 is not a general feature of primary AML, but appears to be restricted to distinct AML subtypes.",

keywords = "Acute myeloid leukemia, Prognosis, Transcription factor, Acute myeloid leukemia, Prognosis, Transcription factor",

author = "Francesco D'Alo' and {Di Ruscio}, Annalisa and Francesco Guidi and Emiliano Fabiani and Mariangela Greco and Carlo Rumi and Stefan Hohaus and Voso, {Maria Teresa}",

year = "2008",

doi = "10.1016/j.leukres.2008.01.007",

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journal = "Leukemia Research",

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T1 - PU.1 and CEBPA expression in acute myeloid leukemia.

AU - D'Alo', Francesco

AU - Di Ruscio, Annalisa

AU - Guidi, Francesco

AU - Fabiani, Emiliano

AU - Greco, Mariangela

AU - Rumi, Carlo

AU - Hohaus, Stefan

AU - Voso, Maria Teresa

PY - 2008

Y1 - 2008

N2 - Alterations of the transcription factors CCAAT/enhancer binding protein alpha (CEBPA) and PU.1 have been described in acute myeloid leukemia (AML). We studied CEBPA and PU.1 mRNA levels by real-time RT-PCR in 109 primary AML samples, compared with normal bone marrow and peripheral blood cells. Low PU.1 levels were observed in monoblastic leukemias, while low CEBPA levels were associated with leukopenia at diagnosis and lack of expression of differentiation antigens CD33 and CD11c. We conclude that down-regulation of CEBPA and PU.1 is not a general feature of primary AML, but appears to be restricted to distinct AML subtypes.

AB - Alterations of the transcription factors CCAAT/enhancer binding protein alpha (CEBPA) and PU.1 have been described in acute myeloid leukemia (AML). We studied CEBPA and PU.1 mRNA levels by real-time RT-PCR in 109 primary AML samples, compared with normal bone marrow and peripheral blood cells. Low PU.1 levels were observed in monoblastic leukemias, while low CEBPA levels were associated with leukopenia at diagnosis and lack of expression of differentiation antigens CD33 and CD11c. We conclude that down-regulation of CEBPA and PU.1 is not a general feature of primary AML, but appears to be restricted to distinct AML subtypes.

KW - Acute myeloid leukemia

KW - Prognosis

KW - Transcription factor

KW - Acute myeloid leukemia

KW - Prognosis

KW - Transcription factor

UR - http://hdl.handle.net/10807/6330

U2 - 10.1016/j.leukres.2008.01.007

DO - 10.1016/j.leukres.2008.01.007

M3 - Article

SN - 0145-2126

SP - 1448

EP - 1453

JO - Leukemia Research

JF - Leukemia Research

ER -

PU.1 and CEBPA expression in acute myeloid leukemia.

Abstract

Keywords

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