PTPN22 1858C>T polymorphism distribution in Europe and association with rheumatoid arthritis: case-control study and meta-analysis

Mc Totaro; Barbara Tolusso; V Napolioni; Francesca Faustini; S Canestri; Alice Mannocci; Elisa Gremese; Sl Bosello; Stefano Alivernini; Gianfranco Ferraccioli

doi:10.1371/journal.pone.0024292

PTPN22 1858C>T polymorphism distribution in Europe and association with rheumatoid arthritis: case-control study and meta-analysis

Mc Totaro
, Barbara Tolusso
, V Napolioni
, Francesca Faustini
, S Canestri
, Alice Mannocci
, Elisa Gremese
, Sl Bosello
, Stefano Alivernini
, Gianfranco Ferraccioli

Sapienza University

Risultato della ricerca: Contributo in rivista › Articolo

39 Citazioni (Scopus)

Abstract

The PTPN22 rs2476601 polymorphism is associated with rheumatoid arthritis (RA); nonetheless, the association is weaker or absent in some southern European populations. The aim of the study was to evaluate the association between the PTPN22 rs2476601 polymorphism and RA in Italian subjects and to compare our results with those of other European countries, carrying out a meta-analysis of European data.

Lingua originale	Inglese
pagine (da-a)	e24292-e24292
Rivista	PLoS One
Volume	6
Numero di pubblicazione	9
DOI	https://doi.org/10.1371/journal.pone.0024292
Stato di pubblicazione	Pubblicato - 2011

Keywords

Adult
Aged
Arthritis
Case-Control Studies
Europe
Gene Frequency
Genetic Predisposition to Disease
Genotype
Geography
Greece
Humans
Italy
Middle Aged
Mutation Rate
Non-Receptor Type 22
Polymorphism
Protein Tyrosine Phosphatase
Rheumatoid
Single Nucleotide
Spain
Tunisia
Turkey

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10.1371/journal.pone.0024292

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abstract = "The PTPN22 rs2476601 polymorphism is associated with rheumatoid arthritis (RA); nonetheless, the association is weaker or absent in some southern European populations. The aim of the study was to evaluate the association between the PTPN22 rs2476601 polymorphism and RA in Italian subjects and to compare our results with those of other European countries, carrying out a meta-analysis of European data.",

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AU - Faustini, Francesca

AU - Canestri, S

AU - Mannocci, Alice

AU - Gremese, Elisa

AU - Bosello, Sl

AU - Alivernini, Stefano

AU - Ferraccioli, Gianfranco

PY - 2011

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AB - The PTPN22 rs2476601 polymorphism is associated with rheumatoid arthritis (RA); nonetheless, the association is weaker or absent in some southern European populations. The aim of the study was to evaluate the association between the PTPN22 rs2476601 polymorphism and RA in Italian subjects and to compare our results with those of other European countries, carrying out a meta-analysis of European data.

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KW - Mutation Rate

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KW - Italy

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KW - Spain

KW - Tunisia

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ER -

PTPN22 1858C>T polymorphism distribution in Europe and association with rheumatoid arthritis: case-control study and meta-analysis

Abstract

Keywords

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