PTPN22 1858C>T polymorphism distribution in Europe and association with rheumatoid arthritis: case-control study and meta-analysis

Elisa Gremese, Stefano Alivernini, Barbara Tolusso, Francesca Faustini, Alice Mannocci, Gianfranco Ferraccioli, Mc Totaro, V Napolioni, S Canestri, Sl Bosello

Risultato della ricerca: Contributo in rivistaArticolo in rivista

39 Citazioni (Scopus)

Abstract

The PTPN22 rs2476601 polymorphism is associated with rheumatoid arthritis (RA); nonetheless, the association is weaker or absent in some southern European populations. The aim of the study was to evaluate the association between the PTPN22 rs2476601 polymorphism and RA in Italian subjects and to compare our results with those of other European countries, carrying out a meta-analysis of European data.
Lingua originaleEnglish
pagine (da-a)e24292-e24292
RivistaPLoS One
Volume6
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • Adult
  • Aged
  • Arthritis, Rheumatoid
  • Case-Control Studies
  • Europe
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Geography
  • Greece
  • Humans
  • Italy
  • Middle Aged
  • Mutation Rate
  • Polymorphism, Single Nucleotide
  • Protein Tyrosine Phosphatase, Non-Receptor Type 22
  • Spain
  • Tunisia
  • Turkey

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