PTPN22 1858C>T polymorphism distribution in Europe and association with rheumatoid arthritis: case-control study and meta-analysis

Mc Totaro; Barbara Tolusso; V Napolioni; Francesca Faustini; S Canestri; Alice Mannocci; Elisa Gremese; Sl Bosello; Stefano Alivernini; Gianfranco Ferraccioli

doi:10.1371/journal.pone.0024292

PTPN22 1858C>T polymorphism distribution in Europe and association with rheumatoid arthritis: case-control study and meta-analysis

Mc Totaro, Barbara Tolusso, V Napolioni, Francesca Faustini, S Canestri, Alice Mannocci, Elisa Gremese, Sl Bosello, Stefano Alivernini, Gianfranco Ferraccioli

Risultato della ricerca: Contributo in rivista › Articolo in rivista

39 Citazioni (Scopus)

Abstract

The PTPN22 rs2476601 polymorphism is associated with rheumatoid arthritis (RA); nonetheless, the association is weaker or absent in some southern European populations. The aim of the study was to evaluate the association between the PTPN22 rs2476601 polymorphism and RA in Italian subjects and to compare our results with those of other European countries, carrying out a meta-analysis of European data.

Lingua originale	English
pagine (da-a)	e24292-e24292
Rivista	PLoS One
Volume	6
DOI	https://doi.org/10.1371/journal.pone.0024292
Stato di pubblicazione	Pubblicato - 2011

Keywords

Adult
Aged
Arthritis, Rheumatoid
Case-Control Studies
Europe
Gene Frequency
Genetic Predisposition to Disease
Genotype
Geography
Greece
Humans
Italy
Middle Aged
Mutation Rate
Polymorphism, Single Nucleotide
Protein Tyrosine Phosphatase, Non-Receptor Type 22
Spain
Tunisia
Turkey

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10.1371/journal.pone.0024292

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abstract = "The PTPN22 rs2476601 polymorphism is associated with rheumatoid arthritis (RA); nonetheless, the association is weaker or absent in some southern European populations. The aim of the study was to evaluate the association between the PTPN22 rs2476601 polymorphism and RA in Italian subjects and to compare our results with those of other European countries, carrying out a meta-analysis of European data.",

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AU - Totaro, Mc

AU - Tolusso, Barbara

AU - Napolioni, V

AU - Faustini, Francesca

AU - Canestri, S

AU - Mannocci, Alice

AU - Gremese, Elisa

AU - Bosello, Sl

AU - Alivernini, Stefano

AU - Ferraccioli, Gianfranco

PY - 2011

Y1 - 2011

N2 - The PTPN22 rs2476601 polymorphism is associated with rheumatoid arthritis (RA); nonetheless, the association is weaker or absent in some southern European populations. The aim of the study was to evaluate the association between the PTPN22 rs2476601 polymorphism and RA in Italian subjects and to compare our results with those of other European countries, carrying out a meta-analysis of European data.

AB - The PTPN22 rs2476601 polymorphism is associated with rheumatoid arthritis (RA); nonetheless, the association is weaker or absent in some southern European populations. The aim of the study was to evaluate the association between the PTPN22 rs2476601 polymorphism and RA in Italian subjects and to compare our results with those of other European countries, carrying out a meta-analysis of European data.

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KW - Aged

KW - Arthritis, Rheumatoid

KW - Case-Control Studies

KW - Europe

KW - Gene Frequency

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Geography

KW - Greece

KW - Humans

KW - Italy

KW - Middle Aged

KW - Mutation Rate

KW - Polymorphism, Single Nucleotide

KW - Protein Tyrosine Phosphatase, Non-Receptor Type 22

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KW - Turkey

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KW - Aged

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KW - Case-Control Studies

KW - Europe

KW - Gene Frequency

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Geography

KW - Greece

KW - Humans

KW - Italy

KW - Middle Aged

KW - Mutation Rate

KW - Polymorphism, Single Nucleotide

KW - Protein Tyrosine Phosphatase, Non-Receptor Type 22

KW - Spain

KW - Tunisia

KW - Turkey

UR - http://hdl.handle.net/10807/3409

U2 - 10.1371/journal.pone.0024292

DO - 10.1371/journal.pone.0024292

M3 - Article

SN - 1932-6203

VL - 6

SP - e24292-e24292

JO - PLoS One

JF - PLoS One

ER -

PTPN22 1858C>T polymorphism distribution in Europe and association with rheumatoid arthritis: case-control study and meta-analysis

Abstract

Keywords

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