TY - JOUR
T1 - Psychological profile and unexpected pain in oral lichen planus: A case–control multicenter SIPMO studya
AU - Adamo, Daniela
AU - Calabria, Elena
AU - Coppola, Noemi
AU - Lo Muzio, Lorenzo
AU - Giuliani, Michele
AU - Bizzoca, Maria Eleonora
AU - Azzi, Lorenzo
AU - Croveri, Fabio
AU - Colella, Giuseppe
AU - Boschetti, Ciro Emiliano
AU - Montebugnoli, Lucio
AU - Gissi, Davide
AU - Gabriele, Mario
AU - Nisi, Marco
AU - Sardella, Andrea
AU - Lodi, Giovanni
AU - Varoni, Elena M.
AU - Giudice, Amerigo
AU - Antonelli, Alessandro
AU - Cabras, Marco
AU - Gambino, Alessio
AU - Vescovi, Paolo
AU - Majorana, Alessandra
AU - Bardellini, Elena
AU - Campisi, Giuseppina
AU - Panzarella, Vera
AU - Francesco, Spadari
AU - Marino, Sonia
AU - Pentenero, Monica
AU - Ardore, Marco
AU - Biasotto, Matteo
AU - Gobbo, Margherita
AU - Guarda Nardini, Luca
AU - Romeo, Umberto
AU - Tenore, Gianluca
AU - Serpico, Rosario
AU - Lajolo, Carlo
AU - Gioco, Gioele
AU - Aria, Massimo
AU - Mignogna, Michele Davide
PY - 2021
Y1 - 2021
N2 - Objectives: To analyze psychological profiles, pain, and oral symptoms in patients with oral lichen planus (OLP). Materials and methods: 300 patients with keratotic OLP (K-OLP; reticular, papular, plaque-like subtypes), 300 patients with predominant non-keratotic OLP (nK-OLP; erythematosus atrophic, erosive, ulcerative, bullous subtypes), and 300 controls were recruited in 15 universities. The number of oral sites involved and oral symptoms were recorded. The Numeric Rating Scale (NRS), Total Pain Rating Index (T-PRI), Hamilton Rating Scales for Depression and for Anxiety (HAM-D and HAM-A), Pittsburgh Sleep Quality Index (PSQI), and Epworth Sleepiness Scale (ESS) were administered. Results: The OLP patients, especially the nK-OLP, showed higher scores in the NRS, T-PRI, HAM-D, HAM-A and PSQI compared with the controls (p-value <.001**). A positive correlation between the NRS, T-PRI, HAM-A, HAM-D, and PSQI was found with the number of oral symptoms and number of oral sites involved. Pain was reported in 67.3% of nK-OLP and 49.7% of K-OLP cases with poor correspondence between the site of lesions and the site of the symptoms. Conclusions: Mood disorders are frequently associated with OLP with an unexpected symptomatology correlated with the number of oral symptoms and with the extension of disease suggesting a peripheral neuropathy.
AB - Objectives: To analyze psychological profiles, pain, and oral symptoms in patients with oral lichen planus (OLP). Materials and methods: 300 patients with keratotic OLP (K-OLP; reticular, papular, plaque-like subtypes), 300 patients with predominant non-keratotic OLP (nK-OLP; erythematosus atrophic, erosive, ulcerative, bullous subtypes), and 300 controls were recruited in 15 universities. The number of oral sites involved and oral symptoms were recorded. The Numeric Rating Scale (NRS), Total Pain Rating Index (T-PRI), Hamilton Rating Scales for Depression and for Anxiety (HAM-D and HAM-A), Pittsburgh Sleep Quality Index (PSQI), and Epworth Sleepiness Scale (ESS) were administered. Results: The OLP patients, especially the nK-OLP, showed higher scores in the NRS, T-PRI, HAM-D, HAM-A and PSQI compared with the controls (p-value <.001**). A positive correlation between the NRS, T-PRI, HAM-A, HAM-D, and PSQI was found with the number of oral symptoms and number of oral sites involved. Pain was reported in 67.3% of nK-OLP and 49.7% of K-OLP cases with poor correspondence between the site of lesions and the site of the symptoms. Conclusions: Mood disorders are frequently associated with OLP with an unexpected symptomatology correlated with the number of oral symptoms and with the extension of disease suggesting a peripheral neuropathy.
KW - anxiety
KW - depression
KW - oral lichen planus
KW - pain
KW - sleep disturbance
KW - anxiety
KW - depression
KW - oral lichen planus
KW - pain
KW - sleep disturbance
UR - http://hdl.handle.net/10807/196361
U2 - 10.1111/odi.13787
DO - 10.1111/odi.13787
M3 - Article
SN - 1354-523X
VL - 28
SP - 398
EP - 414
JO - Oral Diseases
JF - Oral Diseases
ER -