Psychiatry and sensation: the epigenetic links

Madia Lozupone, Ivana Leccisotti, Mario Altamura, Maria Claudia Moretti, Antonello Bellomo, Antonio Daniele, Vittorio Dibello, Emanuela Resta, Francesco Panza

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

A complex interaction among sensory, social and epigenetic determinants in psychiatric conditions was described across all age strata. The high prevalence of mental disorders in individuals with sensory deficits might be attributed to the interaction among social isolation, cognitive functioning and sensory processing. The epigenetic implications of such interactions were examined: environmental and social factors can affect gene expression and impact the pathogenesis of psychiatric disorders also through sensory processing. This article discussed the role of social determinants, in other words, social isolation, loneliness and chronic stress, in promoting psychiatric disorders and, in a vicious circle, sensory deficits (vision, hearing, olfaction and somatosensation). We emphasized the importance of integrating social, sensory and epigenetic factors to target different treatments for psychiatric conditions.
Lingua originaleEnglish
pagine (da-a)1315-1327
Numero di pagine13
RivistaEpigenomics
Volume16
DOI
Stato di pubblicazionePubblicato - 2024

Keywords

  • DNA methylation
  • cognitive impairment
  • depression
  • sensory impairment
  • late-onset depression
  • psychiatry
  • schizophrenia
  • epigenetics

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