The salivary proteome is a complex protein mixture resulting from the
activity of salivary glands with the contribution of other components
that form the oral environment such as oral tissues and micro-organisms.
For diagnosis purposes, saliva collection has the great advantage of
being an easy and non-invasive technique. Human saliva proteomics have
proven to be a novel approach in the search for protein biomarkers for
detection of different local and systemic diseases. Currently, more than
1400 salivary proteins have been identified. In the last few years, our
research group has extensively studied the salivary proteomics in order
to analyse the salivary composition, investigating the major families of
proteins present in human and mammalian saliva, the post-translational
modifications, the different contributions of glands, the physiological and pathological modifications of saliva. The aim of this report is to present our personal experience in salivary proteomics. In conclusion, salivary proteome analysis represents an important field both for
diagnosis and monitoring of various diseases and could be considered a
novel approach to prevention of various pathological conditions.