TY - JOUR
T1 - Proteomics applied to pediatric medicine: opportunities and challenges.
AU - Faa, G
AU - Messana, Irene
AU - Fanos, V
AU - Cabras, Tiziana
AU - Manconi, Barbara
AU - Vento, Giovanni
AU - Iavarone, Federica
AU - Martelli, Claudia
AU - Desiderio, Claudia
AU - Castagnola, Massimo
PY - 2016
Y1 - 2016
N2 - INTRODUCTION:\r\nCare in pediatrics often refers to treatments directed to adults. However, childhood is a specific life period, with molecular pathways connected to development and thereby it requires distinctive considerations and special treatments under disease. Proteomics can help to elucidate the molecular mechanisms underlying the human development and disease onset in pediatric age and this review is devoted to underline the results recently obtained in the field.\r\nAREAS COVERED:\r\nThe contribution of proteomics to the characterization of physiological modifications occurring during human development is presented. The proteomic studies carried out to elucidate the molecular mechanisms underlying different pediatric pathologies and to discover new markers for early diagnosis and prognosis of disease, comprising genetic and systemic pathologies, sepsis and pediatric oncology are thereafter reported. The investigations concerning milk composition in human and farm mammals are also presented. Finally, the chances offered by the integration of different -omic platforms are discussed. Expert commentary: The growing utilization of holistic technologies such as proteomics, metabolomics and microbiomics will allow, in the near future, to define at the molecular level the complexity of human development and related diseases, with great benefit for future generations.
AB - INTRODUCTION:\r\nCare in pediatrics often refers to treatments directed to adults. However, childhood is a specific life period, with molecular pathways connected to development and thereby it requires distinctive considerations and special treatments under disease. Proteomics can help to elucidate the molecular mechanisms underlying the human development and disease onset in pediatric age and this review is devoted to underline the results recently obtained in the field.\r\nAREAS COVERED:\r\nThe contribution of proteomics to the characterization of physiological modifications occurring during human development is presented. The proteomic studies carried out to elucidate the molecular mechanisms underlying different pediatric pathologies and to discover new markers for early diagnosis and prognosis of disease, comprising genetic and systemic pathologies, sepsis and pediatric oncology are thereafter reported. The investigations concerning milk composition in human and farm mammals are also presented. Finally, the chances offered by the integration of different -omic platforms are discussed. Expert commentary: The growing utilization of holistic technologies such as proteomics, metabolomics and microbiomics will allow, in the near future, to define at the molecular level the complexity of human development and related diseases, with great benefit for future generations.
KW - Biomarkers
KW - Biomarkers
UR - https://publicatt.unicatt.it/handle/10807/94960
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84984940159&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84984940159&origin=inward
U2 - 10.1080/14789450.2016.1221764
DO - 10.1080/14789450.2016.1221764
M3 - Article
SN - 1478-9450
VL - 13
SP - 883
EP - 894
JO - Expert Review of Proteomics
JF - Expert Review of Proteomics
IS - 9
ER -