Proteomics and neonatal infection

Giovanni Vento, Chiara Tirone, Claudia Aurilia, Milena Tana, Andrea Piras, A Lio, G Tesfagabir, Massimo Castagnola, Chiara Fanali, Costantino Romagnoli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

1 Citazioni (Scopus)


Antimicrobial peptides plays an important role in the host innate defence network, even in humans. Recent studies demonstrated the capacity of human airways epithelial cells to synthesize antimicrobial peptides, and their multifunctional role in the primary immunity. The presence of ct-defensins in bronchoalveolar lavage fluid (BALF) was investigated in a cohort of preterm newborns with gestational age (GA) < or =30 weeks. BALF samples were analysed by High Performance Liquid Chromatography Electrospray Ionization Mass Spectrometer. Our data show that preterm newborns, also at the lower GA, are able to produce defenses, underlining that their innate defence system is already active before the at-term delivery date.
Lingua originaleEnglish
pagine (da-a)47-49
Numero di pagine3
RivistaMinerva Pediatrica
Stato di pubblicazionePubblicato - 2010


  • Amniotic Fluid
  • Antimicrobial Cationic Peptides
  • Bronchoalveolar Lavage Fluid
  • Chromatography, High Pressure Liquid
  • Cohort Studies
  • Gestational Age
  • Humans
  • Immunity, Innate
  • Infant, Newborn
  • Infant, Premature, Diseases
  • Infection
  • Molecular Structure
  • Proteomics
  • Spectrometry, Mass, Electrospray Ionization
  • alpha-Defensins
  • beta-Defensins


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