Protein intake and muscle health in old age: From biological plausibility to clinical evidence

Francesco Landi*, Riccardo Calvani, Matteo Tosato, Anna Maria Martone, Elena Ortolani, Giulia Savera, Emanuela D'Angelo, Alex Nicholas Sisto, Emanuele Marzetti

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo in rivista

104 Citazioni (Scopus)


The provision of sufficient amounts of dietary proteins is central to muscle health as it ensures the supply of essential amino acids and stimulates protein synthesis. Older persons, in particular, are at high risk of insufficient protein ingestion. Furthermore, the current recommended dietary allowance for protein (0.8 g/kg/day) might be inadequate for maintaining muscle health in older adults, probably as a consequence of “anabolic resistance” in aged muscle. Older individuals therefore need to ingest a greater quantity of protein to maintain muscle function. The quality of protein ingested is also essential to promoting muscle health. Given the role of leucine as the master dietary regulator of muscle protein turnover, the ingestion of protein sources enriched with this essential amino acid, or its metabolite β-hydroxy β-methylbutyrate, is thought to offer the greatest benefit in terms of preservation of muscle mass and function in old age.
Lingua originaleEnglish
pagine (da-a)295-300
Numero di pagine6
Stato di pubblicazionePubblicato - 2016


  • Aged
  • Amino acid
  • Anorexia
  • Dietary Proteins
  • Food Science
  • Frailty
  • Humans
  • Leucine
  • Malnutrition
  • Muscle Proteins
  • Muscle, Skeletal
  • Nutritional Requirements
  • Nutritional Status
  • Sarcopenia
  • Supplementation


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