Protective role of biliary cholesterol and phospholipid lamellae against bile acid-induced cell damage

L Puglielli; L Amigo; M Arrese; L Núñez; A Rigotti; J Garrido; S González; Geltrude Mingrone; Av Greco; L. Accatino

Protective role of biliary cholesterol and phospholipid lamellae against bile acid-induced cell damage

L Puglielli, L Amigo, M Arrese, L Núñez, A Rigotti, J Garrido, S González, Geltrude Mingrone, Av Greco, L. Accatino

Risultato della ricerca: Contributo in rivista › Articolo

Abstract

Bile salts (BS) are cytotoxic agents, but cell damage is not observed in the hepatobiliary system. We hypothesized that biliary lipid vesicles (unilamellae and multilamellae) could have a protective role against BS-induced cytotoxicity.

Lingua originale	Inglese
pagine (da-a)	244-254
Numero di pagine	11
Rivista	Gastroenterology
Volume	107
Stato di pubblicazione	Pubblicato - 1994

Keywords

Animals
Bile
Bile Acids and Salts
Bile Canaliculi
Cell Death
Cholestasis
Cholesterol
Diosgenin
Dose-Response Relationship, Drug
Erythrocytes
Intracellular Membranes
Liver
Male
Microscopy, Electron
Phospholipids
Rats
Rats, Wistar
Taurocholic Acid

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title = "Protective role of biliary cholesterol and phospholipid lamellae against bile acid-induced cell damage",

abstract = "Bile salts (BS) are cytotoxic agents, but cell damage is not observed in the hepatobiliary system. We hypothesized that biliary lipid vesicles (unilamellae and multilamellae) could have a protective role against BS-induced cytotoxicity.",

keywords = "Animals, Bile, Bile Acids and Salts, Bile Canaliculi, Cell Death, Cholestasis, Cholesterol, Diosgenin, Dose-Response Relationship, Drug, Erythrocytes, Intracellular Membranes, Liver, Male, Microscopy, Electron, Phospholipids, Rats, Rats, Wistar, Taurocholic Acid, Animals, Bile, Bile Acids and Salts, Bile Canaliculi, Cell Death, Cholestasis, Cholesterol, Diosgenin, Dose-Response Relationship, Drug, Erythrocytes, Intracellular Membranes, Liver, Male, Microscopy, Electron, Phospholipids, Rats, Rats, Wistar, Taurocholic Acid",

author = "L Puglielli and L Amigo and M Arrese and L N{\'u}{\~n}ez and A Rigotti and J Garrido and S Gonz{\'a}lez and Geltrude Mingrone and Av Greco and L. Accatino",

year = "1994",

language = "English",

volume = "107",

pages = "244--254",

journal = "Gastroenterology",

issn = "0016-5085",

publisher = "W.B. Saunders",

}

TY - JOUR

T1 - Protective role of biliary cholesterol and phospholipid lamellae against bile acid-induced cell damage

AU - Puglielli, L

AU - Amigo, L

AU - Arrese, M

AU - Núñez, L

AU - Rigotti, A

AU - Garrido, J

AU - González, S

AU - Mingrone, Geltrude

AU - Greco, Av

AU - Accatino, L.

PY - 1994

Y1 - 1994

N2 - Bile salts (BS) are cytotoxic agents, but cell damage is not observed in the hepatobiliary system. We hypothesized that biliary lipid vesicles (unilamellae and multilamellae) could have a protective role against BS-induced cytotoxicity.

AB - Bile salts (BS) are cytotoxic agents, but cell damage is not observed in the hepatobiliary system. We hypothesized that biliary lipid vesicles (unilamellae and multilamellae) could have a protective role against BS-induced cytotoxicity.

KW - Animals

KW - Bile

KW - Bile Acids and Salts

KW - Bile Canaliculi

KW - Cell Death

KW - Cholestasis

KW - Cholesterol

KW - Diosgenin

KW - Dose-Response Relationship, Drug

KW - Erythrocytes

KW - Intracellular Membranes

KW - Liver

KW - Male

KW - Microscopy, Electron

KW - Phospholipids

KW - Rats

KW - Rats, Wistar

KW - Taurocholic Acid

KW - Animals

KW - Bile

KW - Bile Acids and Salts

KW - Bile Canaliculi

KW - Cell Death

KW - Cholestasis

KW - Cholesterol

KW - Diosgenin

KW - Dose-Response Relationship, Drug

KW - Erythrocytes

KW - Intracellular Membranes

KW - Liver

KW - Male

KW - Microscopy, Electron

KW - Phospholipids

KW - Rats

KW - Rats, Wistar

KW - Taurocholic Acid

UR - http://hdl.handle.net/10807/7067

M3 - Article

SN - 0016-5085

VL - 107

SP - 244

EP - 254

JO - Gastroenterology

JF - Gastroenterology

ER -

Protective role of biliary cholesterol and phospholipid lamellae against bile acid-induced cell damage

Abstract

Keywords

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