Protective role of biliary cholesterol and phospholipid lamellae against bile acid-induced cell damage

Geltrude Mingrone, L Puglielli, L Amigo, M Arrese, L Núñez, A Rigotti, J Garrido, S González, Av Greco, L. Accatino

Risultato della ricerca: Contributo in rivistaArticolo in rivista

50 Citazioni (Scopus)

Abstract

Bile salts (BS) are cytotoxic agents, but cell damage is not observed in the hepatobiliary system. We hypothesized that biliary lipid vesicles (unilamellae and multilamellae) could have a protective role against BS-induced cytotoxicity.
Lingua originaleEnglish
pagine (da-a)244-254
Numero di pagine11
RivistaGastroenterology
Volume107
Stato di pubblicazionePubblicato - 1994

Keywords

  • Animals
  • Bile
  • Bile Acids and Salts
  • Bile Canaliculi
  • Cell Death
  • Cholestasis
  • Cholesterol
  • Diosgenin
  • Dose-Response Relationship, Drug
  • Erythrocytes
  • Intracellular Membranes
  • Liver
  • Male
  • Microscopy, Electron
  • Phospholipids
  • Rats
  • Rats, Wistar
  • Taurocholic Acid

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