Protective Effects of Gynostemma pentaphyllum (var. Ginpent) against Lipopolysaccharide-Induced Inflammation and Motor Alteration in Mice

Luigi Lucini, Leilei Zhang, Andrea Mastinu, Sara Anna Bonini, Marika Premoli, Giuseppina Maccarinelli, Eileen Mac Sweeney, Maurizio Memo

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

11 Citazioni (Scopus)

Abstract

Gynostemma pentaphyllum (var. Ginpent) (GP) is a variety of Cucurbit with anti-inflammatory and antioxidant effects in patients. In this manuscript, the main components present in the dry extract of GP have been identified using Ultra High Performance Liquid Chromatography quadrupole-time-of-flight mass spectrometry (UHPLC/Q-TOF-MS). In addition, the anti-inflammatory action of GP was evaluated in animal models with acute peripheral inflammation and motor alteration induced by lipopolysaccharide. The results showed that GP dry extract is rich in secondary metabolites with potential antioxidant and anti-inflammatory properties. We found that the treatment with GP induced a recovery of motor function measured with the rotarod test and pole test, and a reduction in inflammatory cytokines such as interleukin-1β and interleukin-6 measured with the ELISA test. The data collected in this study on the effects of GP in in vivo models may help integrate the therapeutic strategies of inflammatory-based disorders.
Lingua originaleEnglish
pagine (da-a)570-570
Numero di pagine1
RivistaMolecules
Volume26
DOI
Stato di pubblicazionePubblicato - 2021

Keywords

  • Animals
  • Anti-Inflammatory Agents
  • Antioxidants
  • Cytokines
  • ELISA
  • Gynostemma
  • Gynostemma pentaphyllum
  • Humans
  • Inflammation
  • Lipopolysaccharides
  • Male
  • Mice
  • Mice, 129 Strain
  • Mice, Inbred C57BL
  • Motor Activity
  • Phytosterols
  • Phytotherapy
  • Plant Extracts
  • Polyphenols
  • Saponins
  • anti-inflammatory
  • motility
  • supplement

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