Abstract
| Lingua originale | English |
|---|---|
| pagine (da-a) | 509-520 |
| Numero di pagine | 12 |
| Rivista | INTERNAL AND EMERGENCY MEDICINE |
| Volume | 8 |
| DOI | |
| Stato di pubblicazione | Pubblicato - 2013 |
Keywords
- TVP
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Prophylaxis of venous thromboembolism in elderly patients with multimorbidity. / Grieco, Antonio; Marcucci, Maura; Iorio, Alfonso et al.
In: INTERNAL AND EMERGENCY MEDICINE, Vol. 8, 2013, pag. 509-520.Risultato della ricerca: Contributo in rivista › Articolo in rivista
TY - JOUR
T1 - Prophylaxis of venous thromboembolism in elderly patients with multimorbidity
AU - Grieco, Antonio
AU - Marcucci, Maura
AU - Iorio, Alfonso
AU - Nobili, Alessandro
AU - Tettamanti, Mauro
AU - Pasina, Luca
AU - Djade, Codjo Djignefa
AU - Marengoni, Alessandra
AU - Salerno, Francesco
AU - Corrao, Salvatore
AU - Mannucci, Pier Mannuccio
AU - Franchi, Carlotta
AU - Sparacio, Eleonora
AU - Alborghetti, Stefania
AU - Di Costanzo, Rosa
AU - Prisco, Domenico
AU - Silvestri, Elena
AU - Cenci, Caterina
AU - Barnini, Tommaso
AU - Delitala, Giuseppe
AU - Carta, Stefano
AU - Atzori, Sebastiana
AU - Guarnieri, Gianfranco
AU - Zanetti, Michela
AU - Spalluti, Annalisa
AU - Serra, Maria Grazia
AU - Bleve, Maria Antonietta
AU - Vanoli, Massimo
AU - Grignani, Giulia
AU - Casella, Gianluca
AU - Gasbarrone, Laura
AU - Maniscalco, Giorgio
AU - Gunelli, Massimo
AU - Tirotta, Daniela
AU - Brucato, Antonio
AU - Ghidoni, Silvia
AU - Di Corato, Paola
AU - Bernardi, Mauro
AU - Bassi, Silvia Li
AU - Santi, Luca
AU - Agnelli, Giancarlo
AU - Marchesini, Emanuela
AU - Mannarino, Elmo
AU - Lupattelli, Graziana
AU - Rondelli, Pamela
AU - Paciullo, Francesco
AU - Fabris, Fabrizio
AU - Carlon, Michela
AU - Turatto, Francesca
AU - Baroni, Maria Cristina
AU - Zardo, Marianna
AU - Manfredini, Roberto
AU - Molino, Christian
AU - Pala, Marco
AU - Fabbian, Fabio
AU - Nuti, Ranuccio
AU - Valenti, Roberto
AU - Ruvio, Martina
AU - Cappelli, Silvia
AU - Paolisso, Giuseppe
AU - Rizzo, Maria Rosaria
AU - Laieta, Maria Teresa
AU - Salvatore, Teresa
AU - Sasso, Ferdinando Carlo
AU - Utili, Riccardo
AU - Mangoni, Emanuele Durante
AU - Pinto, Daniela
AU - Olivieri, Oliviero
AU - Stanzial, Anna Maria
AU - Fellin, Renato
AU - Volpato, Stefano
AU - Fotini, Sioulis
AU - Barbagallo, Mario
AU - Dominguez, Ligia
AU - Plances, Lidia
AU - D’Angelo, Daniela
AU - Rini, Giovanbattista
AU - Mansueto, Pasquale
AU - Pepe, Ilenia
AU - Licata, Giuseppe
AU - Calvo, Luigi
AU - Valenti, Maria
AU - Borghi, Claudio
AU - Strocchi, Enrico
AU - Rinaldi, Elisa Rebecca
AU - Zoli, Marco
AU - Fabbri, Elisa
AU - Magalotti, Donatella
AU - Auteri, Alberto
AU - Pasqui, Anna Laura
AU - Puccetti, Luca
AU - Pasini, Franco Laghi
AU - Capecchi, Pier Leopoldo
AU - Bicchi, Maurizio
AU - Sabbà, Carlo
AU - Vella, Francesco Saverio
AU - Marseglia, Alessandro
AU - Luglio, Chiara Valentina
AU - Palasciano, Giuseppe
AU - Modeo, Maria Ester
AU - Aquilino, Annamaria
AU - Raffaele, Pallante
AU - Pugliese, Stefania
AU - Capobianco, Caterina
AU - Postiglione, Alfredo
AU - Barbella, Maria Rosaria
AU - De Stefano, Francesco
AU - Fenoglio, Luigi
AU - Brignone, Chiara
AU - Bracco, Christian
AU - Giraudo, Alessia
AU - Musca, Giuseppe
AU - Cuccurullo, Olga
AU - Cricco, Luigi
AU - Fiorentini, Alessandra
AU - Cappellini, Maria Domenica
AU - Fabio, Giovanna
AU - Seghezzi, Sonia
AU - De Amicis, Margherita Migone
AU - Fargion, Silvia
AU - Bonara, Paola
AU - Bulgheroni, Mara
AU - Lombardi, Rosa
AU - Magrini, Fabio
AU - Massari, Ferdinando
AU - Tonella, Tatiana
AU - Peyvandi, Flora
AU - Tedeschi, Alberto
AU - Rossio, Raffaella
AU - Moreo, Guido
AU - Ferrari, Barbara
AU - Roncari, Luisa
AU - Monzani, Valter
AU - Savojardo, Valeria
AU - Folli, Christian
AU - Magnini, Maria
AU - Mari, Daniela
AU - Rossi, Paolo Dionigi
AU - Damanti, Sarah
AU - Prolo, Silvia
AU - Lilleri, Maria Sole
AU - Micale, Giuliana
AU - Podda, Mauro
AU - Selmi, Carlo
AU - Meda, Francesca
AU - Accordino, Silvia
AU - Conca, Alessio
AU - Monti, Valentina
AU - Corazza, Gino Roberto
AU - Miceli, Emanuela
AU - Lenti, Marco Vincenzo
AU - Padula, Donatella
AU - Balduini, Carlo L.
AU - Bertolino, Giampiera
AU - Provini, Stella
AU - Quaglia, Federica
AU - Murialdo, Giovanni
AU - Bovio, Marta
AU - Dallegri, Franco
AU - Ottonello, Luciano
AU - Quercioli, Alessandra
AU - Barreca, Alessandra
AU - Secchi, Maria Beatrice
AU - Ghelfi, Davide
AU - Chin, Wu Sheng
AU - Carassale, Laura
AU - Caporotundo, Silvia
AU - Anastasio, Luigi
AU - Sofia, Lucia
AU - Carbone, Maria
AU - Traisci, Giancarlo
AU - De Feudis, Lucrezia
AU - Di Carlo, Silvia
AU - Daví, Giovanni
AU - Guagnano, Maria Teresa
AU - Sestili, Simona
AU - Bergami, Elisabetta
AU - Rizzioli, Emanuela
AU - Cagnoni, Carlo
AU - Bertone, Luca
AU - Manucra, Antonio
AU - Buratti, Alberto
AU - Tognin, Tiziana
AU - Liberato, Nicola Lucio
AU - Bernasconi, Giordano
AU - Nardo, Barbara
AU - Bianchi, Giovanni Battista
AU - Benetti, Giampiero
AU - Quagliolo, Michela
AU - Centenaro, Giuseppe Riccardo
AU - Purrello, Francesco
AU - Di Pino, Antonino
AU - Piro, Salvatore
AU - Mancuso, Gerardo
AU - Calipari, Daniela
AU - Bartone, Mosè
AU - Gullo, Francesco
AU - Cortellaro, Michele
AU - Magenta, Marina
AU - Perego, Francesca
AU - Meroni, Maria Rachele
AU - Cicardi, Marco
AU - Magenta, Antonio Gidaro Marina
AU - Sacco, Andrea
AU - Bonelli, Antonio
AU - Dentamaro, Gaetano
AU - Rozzini, Renzo
AU - Falanga, Lina
AU - Giordano, Alessandro
AU - Perin, Paolo Cavallo
AU - Lorenzati, Bartolomeo
AU - Gruden, Gabriella
AU - Bruno, Graziella
AU - Montrucchio, Giuseppe
AU - Greco, Elisabetta
AU - Tizzani, Pietro
AU - Fera, Giacomo
AU - Di Luca, Maria Loreta
AU - Renna, Donatella
AU - Perciccante, Antonio
AU - Coralli, Alessia
AU - Tassara, Rodolfo
AU - Melis, Deborah
AU - Rebella, Lara
AU - Menardo, Giorgio
AU - Bottone, Stefania
AU - Sferrazzo, Elsa
AU - Ferri, Claudio
AU - Striuli, Rinaldo
AU - Scipioni, Rosa
AU - Salmi, Raffaella
AU - Gaudenzi, Piergiorgio
AU - Gamberini, Susanna
AU - Ricci, Franco
AU - Morabito, Cosimo
AU - Fava, Roberto
AU - Semplicini, Andrea
AU - Gottardo, Lucia
AU - Vendemiale, Gianluigi
AU - Serviddio, Gaetano
AU - Forlano, Roberta
AU - Bolondi, Luigi
AU - Rasciti, Leonardo
AU - Serio, Ilaria
AU - Masala, Cesare
AU - Mammarella, Antonio
AU - Raparelli, Valeria
AU - Fanelli, Filippo Rossi
AU - Delfino, Massimo
AU - Amoroso, Antonio
AU - Violi, Francesco
AU - Basili, Stefania
AU - Perri, Ludovica
AU - Serra, Pietro
AU - Fontana, Vincenzo
AU - Falcone, Marco
AU - Bellusci, Martino
AU - Setti, Donatella
AU - Pedrazzoli, Filippo
AU - Romanelli, Giuseppe
AU - Pirali, Caterina
AU - Amolini, Claudia
AU - Rosei, Enrico Agabiti
AU - Rizzoni, Damiano
AU - Castoldi, Luana
AU - Picardi, Antonio
AU - Gentilucci, Umberto Vespasiani
AU - Mazzarelli, Chiara
AU - Gallo, Paolo
AU - Guasti, Luigina
AU - Castiglioni, Luana
AU - Maresca, Andrea
AU - Squizzato, Alessandro
AU - Contini, Sara
AU - Molaro, Marta
AU - Annoni, Giorgio
AU - Zazzetta, Maurizio Corsi Sara
AU - Bertolotti, Marco
AU - Scotto, Chiara Mussi Roberto
AU - Ferri, Maria Alice
AU - Veltri, Francesca
AU - Arturi, Franco
AU - Succurro, Elena
AU - Sesti, Giorgio
AU - Gualtieri, Umberto
AU - Perticone, Francesco
AU - Sciacqua, Angela
AU - Quero, Michele
AU - Bagnato, Chiara
AU - Loria, Paola
AU - Becchi, Maria Angela
AU - Martucci, Gianfranco
AU - Fantuzzi, Alessandra
AU - Maurantonio, Mauro
AU - Corinaldesi, Roberto
AU - De Giorgio, Roberto
AU - Serra, Mauro
AU - Grasso, Valentina
AU - Ruggeri, Eugenio
AU - Carozza, Lorenzo Mauro
AU - Pignatti, Fabio
PY - 2013
Y1 - 2013
N2 - Pharmacological thromboprophylaxis (TP) is known to reduce venous thromboembolism (VTE) in medical inpatients, but the criteria for risk-driven prescription, safety and impact on mortality are still debated. We analyze data on elderly patients with multimorbidities admitted in the year 2010 to the Italian internal medicine wards participating in the REPOSI registry to investigate the rate of TP during the hospital stay, and analyze the factors that are related to its prescription. Multivariate logistic regression, area under the ROC curve and CART analysis were performed to look for independent predictors of TP prescription. Association between TP and VTE, bleeding and death in hospital and during the 3-month post-discharge follow-up were explored by logistic regression and propensity score analysis. Among the 1,380 patients enrolled, 171 (15.2 %) were on TP during the hospital stay (162 on low molecular weight heparins, 9 on fondaparinux). The disability Barthel index was the main independent predictor of TP prescription. Rate of fatal and non-fatal VTE and bleeding during and after hospitalization did not differ between TP and non-TP patients. In-hospital and post-discharge mortality was significantly higher in patients on TP, that however was not an independent predictor of mortality. Among elderly medical patients there was a relatively low rate of TP, that was more frequently prescribed to patients with a higher degree of disability and who had an overall higher mortality.
AB - Pharmacological thromboprophylaxis (TP) is known to reduce venous thromboembolism (VTE) in medical inpatients, but the criteria for risk-driven prescription, safety and impact on mortality are still debated. We analyze data on elderly patients with multimorbidities admitted in the year 2010 to the Italian internal medicine wards participating in the REPOSI registry to investigate the rate of TP during the hospital stay, and analyze the factors that are related to its prescription. Multivariate logistic regression, area under the ROC curve and CART analysis were performed to look for independent predictors of TP prescription. Association between TP and VTE, bleeding and death in hospital and during the 3-month post-discharge follow-up were explored by logistic regression and propensity score analysis. Among the 1,380 patients enrolled, 171 (15.2 %) were on TP during the hospital stay (162 on low molecular weight heparins, 9 on fondaparinux). The disability Barthel index was the main independent predictor of TP prescription. Rate of fatal and non-fatal VTE and bleeding during and after hospitalization did not differ between TP and non-TP patients. In-hospital and post-discharge mortality was significantly higher in patients on TP, that however was not an independent predictor of mortality. Among elderly medical patients there was a relatively low rate of TP, that was more frequently prescribed to patients with a higher degree of disability and who had an overall higher mortality.
KW - TVP
KW - TVP
UR - http://hdl.handle.net/10807/52801
U2 - 10.1007/s11739-013-0944-8
DO - 10.1007/s11739-013-0944-8
M3 - Article
VL - 8
SP - 509
EP - 520
JO - INTERNAL AND EMERGENCY MEDICINE
JF - INTERNAL AND EMERGENCY MEDICINE
SN - 1970-9366
ER -