Prophylactic ibuprofen therapy of patent ductus arteriosus in preterm infants.

Angelica Bibiana Delogu, Maria Pia De Carolis, Enrico Zecca, Giuseppe Gio Batta Tortorolo, Costantino Romagnoli, Valentina Polimeni, Fiammetta Piersigilli, Papacci Papacci

Risultato della ricerca: Contributo in rivistaArticolo in rivista

71 Citazioni (Scopus)

Abstract

This study was aimed at evaluating the efficacy of ibuprofen in the prophylaxis of patent ductus arteriosus (PDA) in very preterm neonates and at detecting eventual side-effects. A total of 46 preterm neonates with gestational age under 31 weeks were randomly assigned at 2 h of life: 23 to the prophylaxis group and 23 to the control group. The prophylaxis group received intravenous treatment with ibuprofen lysine (10 mg/kg), followed by 5 mg/kg after 24 h and 48 h. No placebo was given to the control group. No PDA was demonstrated at 72 h of life in 20 of the 23 babies in the ibuprofen group (87%) nor in 7 of the 23 control neonates (30.4%). All neonates with PDA received treatment with indomethacin. One neonate in the prophylaxis group and three in the control group underwent surgical ligation. Prophylaxis with ibuprofen was not associated with any significant side-effect except for food intolerance. CONCLUSION: Ibuprofen prophylaxis seems to be efficient in closing patent ductus arteriosus and in reducing indomethacin treatment. No significant early side-effects were found due to ibuprofen.
Lingua originaleEnglish
pagine (da-a)364-368
Numero di pagine5
RivistaEuropean Journal of Pediatrics
Stato di pubblicazionePubblicato - 2000

Keywords

  • Prophylactic ibuprofen therapy
  • patent ductus arteriosus

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