Prophylactic aspirin therapy does not increase faecal calprotectin concentrations.

Massimo Montalto, Valentina Curigliano, Luca Santoro, M Lombardi, Marcello Covino, Giovanni Cammarota, Sara Dalvai, Fabio D'Onofrio, Antonio Gasbarrini, Giovanni Battista Gasbarrini

Risultato della ricerca: Contributo in rivistaArticolo in rivista

16 Citazioni (Scopus)


OBJECTIVE: Non-steroidal anti-inflammatory drugs (NSAID) can induce enteropathy. Aspirin ingestion is associated with a lower small-intestinal inflammation than other NSAID. Faecal calprotectin concentrations have recently been proposed as a simple non-invasive test to identify NSAID enteropathy. The aim of our pilot study was to evaluate calprotectin concentrations in patients on treatment with low-dose aspirin. METHODS: Twenty-two patients on prophylactic treatment with aspirin were recruited. Twenty-five healthy volunteers were enrolled as a control group. Faecal calprotectin concentrations were determined by enzyme-linked immunosorbent assay. Statistical analysis was performed by t-test for unpaired data. RESULTS: The mean faecal calprotectin concentration in patients (57.95+/-44.28 microg/g) did not show significant differences compared with controls (45.76+/-26.45 microg/g; P=0.251). CONCLUSIONS: We found that low-dose aspirin does not induce an increase in faecal calprotectin increase
Lingua originaleEnglish
pagine (da-a)965-967
Numero di pagine3
Stato di pubblicazionePubblicato - 2006


  • prophylactic


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