TY - JOUR
T1 - Propensity score-matched comparison of short- and long-term outcomes between surgery and endoscopic submucosal dissection (ESD) for intestinal type early gastric cancer (EGC) of the middle and lower third of the stomach: a European tertiary referral center experience
AU - Quero, Giuseppe
AU - Fiorillo, Claudio
AU - Longo, F.
AU - Laterza, Vito
AU - Rosa, Fausto
AU - Cina, C.
AU - Menghi, Roberta
AU - Tortorelli, Antonio Pio
AU - Barbaro, Federico
AU - Pecere, Silvia
AU - Petruzziello, Lucio
AU - Costamagna, Guido
AU - Alfieri, Sergio
PY - 2021
Y1 - 2021
N2 - Background: Despite the comparable results between ESD and gastrectomy reported in multiple Asiatic studies, limited data are currently present on the long-term efficacy of ESD for EGC in Western countries. The aim of this study was to compare the short- and long-term outcomes of the endoscopic submucosal dissection and surgery for non-diffuse early gastric cancer treatment in a Western cohort of patients. Methods: All patients with a diagnosis of intestinal type EGC located in the middle and lower third of the stomach from 2005 to 2015 were enrolled in the study. All patients completed a 5-year follow-up. Patients were divided according to the procedure performed (ESD/subtotal gastrectomy). The two groups were matched for age, gender, ASA score, tumor dimension, and grade of infiltration (mucosa/submucosa). Results: After matching, 84 patients (42 per group) were included in the analysis. Peri-procedural morbidity rate was 7.1% and no difference was observed between the two groups (4.8% vs 9.5% for ESD and STG groups, respectively; p = 0.3). Similar results in terms of 5-year OS and DFS were observed for ESD and STG (77.7% vs 71.8% ; p = 0.78 and 74.9% vs 72% ; p = 0.7, respectively). At the multivariate analysis, ASA3 score was recognized as the only negative predictor factor for the 5-year OS (OR 6.2; 95% CI 2.2–16.8; p < 0.001). Regarding the DFS, both ASA3 score (OR 4.4; 95% CI 1.7–10.9; p < 0.001) and submucosal infiltration(OR 5.1; 95% CI 1.2–22.4 ; p = 0.02) were identified as independent risk factors for a worse outcome. Conclusions: Our results confirm the safety and feasibility ESD for EGC treatment in a Western setting. In addition, this is one of the few reports showing comparable results both in terms of short- and long-term outcomes between ESD and surgery for intestinal type ECG treatment in Western countries.
AB - Background: Despite the comparable results between ESD and gastrectomy reported in multiple Asiatic studies, limited data are currently present on the long-term efficacy of ESD for EGC in Western countries. The aim of this study was to compare the short- and long-term outcomes of the endoscopic submucosal dissection and surgery for non-diffuse early gastric cancer treatment in a Western cohort of patients. Methods: All patients with a diagnosis of intestinal type EGC located in the middle and lower third of the stomach from 2005 to 2015 were enrolled in the study. All patients completed a 5-year follow-up. Patients were divided according to the procedure performed (ESD/subtotal gastrectomy). The two groups were matched for age, gender, ASA score, tumor dimension, and grade of infiltration (mucosa/submucosa). Results: After matching, 84 patients (42 per group) were included in the analysis. Peri-procedural morbidity rate was 7.1% and no difference was observed between the two groups (4.8% vs 9.5% for ESD and STG groups, respectively; p = 0.3). Similar results in terms of 5-year OS and DFS were observed for ESD and STG (77.7% vs 71.8% ; p = 0.78 and 74.9% vs 72% ; p = 0.7, respectively). At the multivariate analysis, ASA3 score was recognized as the only negative predictor factor for the 5-year OS (OR 6.2; 95% CI 2.2–16.8; p < 0.001). Regarding the DFS, both ASA3 score (OR 4.4; 95% CI 1.7–10.9; p < 0.001) and submucosal infiltration(OR 5.1; 95% CI 1.2–22.4 ; p = 0.02) were identified as independent risk factors for a worse outcome. Conclusions: Our results confirm the safety and feasibility ESD for EGC treatment in a Western setting. In addition, this is one of the few reports showing comparable results both in terms of short- and long-term outcomes between ESD and surgery for intestinal type ECG treatment in Western countries.
KW - Early gastric cancer
KW - Endoscopic submucosal dissection
KW - Gastrectomy
KW - Western countries
KW - Early gastric cancer
KW - Endoscopic submucosal dissection
KW - Gastrectomy
KW - Western countries
UR - http://hdl.handle.net/10807/177532
U2 - 10.1007/s00464-020-07677-3
DO - 10.1007/s00464-020-07677-3
M3 - Article
SN - 0930-2794
VL - 35
SP - 2592
EP - 2600
JO - Surgical Endoscopy
JF - Surgical Endoscopy
ER -