Progressive multifocal leukoencephalopathy in a patient with Franklin disease and hypogammaglobulinemia.

Massimiliano Mirabella, Enzo Ricci, Mario Sabatelli, Giorgio Tasca, Raffaele Iorio, Umberto Basile, Libero Lauriola, Raffaele Tartaglione

Risultato della ricerca: Contributo in rivistaArticolo in rivista

9 Citazioni (Scopus)

Abstract

We report an association between histologically confirmed progressive multifocal leukoencephalopathy (PML) and an extremely rare humoral immunodeficiency disease, Franklin disease. In our patient, clinical presentation has been typical and prompted us, together with radiological findings, to perform a brain biopsy to confirm the diagnosis even if there was no evidence of any other risk factor except hypogammaglobulinemia. We suggest that PML should be suspected in patients in whom immunosuppression is not obvious (i.e. not only in the setting of HIV infection or disseminated end-stage lymphomas) and involves defects in humoral immunity.
Lingua originaleEnglish
pagine (da-a)203-204
Numero di pagine2
RivistaJournal of the Neurological Sciences
Stato di pubblicazionePubblicato - 2009

Keywords

  • Brain biopsy
  • PML

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