Prognostic value of virological and immunological responses after 6 months of antiretroviral treatment in adults with HIV-1 infection in sub-Saharan Africa

Andrea De Luca, Barbara Pedruzzi, Mc Marazzi, S Mancinelli, S Ceffa, Amd Altan, E Buonomo, Mcf Prosperi, Am Noorjehan, P Scarcella, G Liotta, L. Palombi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

16 Citazioni (Scopus)

Abstract

HIV RNA monitoring is not available in most antiretroviral treatment (ART) programs in sub-Saharan Africa; switch to second-line therapy is mostly guided by clinical/immunological criteria. This may lead to unnecessary disease progression and drug resistance accumulation. We investigated the prognostic value of virological and immunological status 6 months after ART initiation with respect to death, loss to follow-up, and treatment switch.
Lingua originaleEnglish
pagine (da-a)236-244
Numero di pagine9
RivistaJournal of Acquired Immune Deficiency Syndromes
Volume59
DOI
Stato di pubblicazionePubblicato - 2012

Keywords

  • Adult
  • Africa South of the Sahara
  • Anti-HIV Agents
  • CD4 Lymphocyte Count
  • Cohort Studies
  • Drug Administration Schedule
  • Female
  • HIV Infections
  • HIV-1
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Patient Compliance
  • Predictive Value of Tests
  • Prospective Studies
  • RNA, Viral
  • Viral Load

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