TY - JOUR
T1 - Prognostic Value of EEG Microstates in Acute Stroke
AU - Zappasodi, Filippo
AU - Croce, Pierpaolo
AU - Giordani, Alessandro
AU - Assenza, Giovanni
AU - Giannantoni, Nadia M.
AU - Profice, Paolo
AU - Granata, Giuseppe
AU - Rossini, Paolo Maria
AU - Tecchio, Franca
PY - 2017
Y1 - 2017
N2 - Given the importance of neuronal plasticity in recovery from a stroke and the huge variability of recovery abilities in patients, we investigated neuronal activity in the acute phase to enhance information about the prognosis of recovery in the stabilized phase. We investigated the microstates in 47 patients who suffered a first-ever mono-lesional ischemic stroke in the middle cerebral artery territory and in 20 healthy control volunteers. Electroencephalographic (EEG) activity at rest with eyes closed was acquired between 2 and 10 days (T0) after ischemic attack. Objective criteria allowed for the selection of an optimal number of microstates. Clinical condition was quantified by the National Institute of Health Stroke Scale (NIHSS) both in acute (T0) and stabilized (T1, 5.4 ± 1.7 months) phases and Effective Recovery (ER) was calculated as (NIHSS(T1)-NIHSS(T0))/NIHSS(T0). The microstates A, B, C and D emerged as the most stable. In patients with a left lesion inducing a language impairment, microstate C topography differed from controls. Microstate D topography was different in patients with a right lesion inducing neglect symptoms. In patients, the C vs D microstate duration differed after both a left and a right lesion with respect to controls (C lower than D in left and D lower than C in right lesion). A preserved microstate B in acute phase correlated with a better effective recovery. A regression model indicated that the microstate B duration explained the 11% of ER variance. This first ever study of EEG microstates in acute stroke opens an interesting path to identify neuronal impairments with prognostic relevance, to develop enriched compensatory treatments to drive a better individual recovery.
AB - Given the importance of neuronal plasticity in recovery from a stroke and the huge variability of recovery abilities in patients, we investigated neuronal activity in the acute phase to enhance information about the prognosis of recovery in the stabilized phase. We investigated the microstates in 47 patients who suffered a first-ever mono-lesional ischemic stroke in the middle cerebral artery territory and in 20 healthy control volunteers. Electroencephalographic (EEG) activity at rest with eyes closed was acquired between 2 and 10 days (T0) after ischemic attack. Objective criteria allowed for the selection of an optimal number of microstates. Clinical condition was quantified by the National Institute of Health Stroke Scale (NIHSS) both in acute (T0) and stabilized (T1, 5.4 ± 1.7 months) phases and Effective Recovery (ER) was calculated as (NIHSS(T1)-NIHSS(T0))/NIHSS(T0). The microstates A, B, C and D emerged as the most stable. In patients with a left lesion inducing a language impairment, microstate C topography differed from controls. Microstate D topography was different in patients with a right lesion inducing neglect symptoms. In patients, the C vs D microstate duration differed after both a left and a right lesion with respect to controls (C lower than D in left and D lower than C in right lesion). A preserved microstate B in acute phase correlated with a better effective recovery. A regression model indicated that the microstate B duration explained the 11% of ER variance. This first ever study of EEG microstates in acute stroke opens an interesting path to identify neuronal impairments with prognostic relevance, to develop enriched compensatory treatments to drive a better individual recovery.
KW - Acute stroke
KW - Anatomy
KW - Electroencephalography (EEG)
KW - Microstates
KW - Neurology
KW - Neurology (clinical)
KW - Prognosis
KW - Radiological and Ultrasound Technology
KW - Radiology, Nuclear Medicine and Imaging
KW - Resting state
KW - Acute stroke
KW - Anatomy
KW - Electroencephalography (EEG)
KW - Microstates
KW - Neurology
KW - Neurology (clinical)
KW - Prognosis
KW - Radiological and Ultrasound Technology
KW - Radiology, Nuclear Medicine and Imaging
KW - Resting state
UR - http://hdl.handle.net/10807/111821
UR - http://www.wkap.nl/journalhome.htm/0896-0267
U2 - 10.1007/s10548-017-0572-0
DO - 10.1007/s10548-017-0572-0
M3 - Article
SN - 0896-0267
VL - 30
SP - 698
EP - 710
JO - Brain Topography
JF - Brain Topography
ER -