Prognostic Value of Chemotherapy Response Score (CRS) Assessed on the Adnexa in Ovarian High-Grade Serous Carcinoma: A Systematic Review and Meta-Analysis

Angela Santoro, Antonio Travaglino, Frediano Inzani, Patrizia Straccia, Damiano Arciuolo, Michele Valente, Nicoletta D'Alessandris, Giulia Scaglione, Giuseppe Angelico, Alessia Piermattei, Federica Cianfrini, Antonio Raffone, Gian Franco Zannoni

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Background: chemotherapy response score (CRS) is widely used to assess the response of ovarian high-grade serous carcinoma (HGSC) to chemotherapy and is based on pathological examination of omental specimens. We aimed to assess the prognostic value of CRS assessed on the uterine adnexa. Methods: a systematic review and meta-analysis were performed by searching three electronic databases from 2015 inception to September 2021. We included all studies reporting either hazard ratio (HR) with 95% confidence interval (CI) for progression-free survival (PFS) or primary PFS data, for both adnexal and omental CRS in HGSC. HRs with 95% CI were extracted and pooled by using a significant p-value < 0.05. Statistical heterogeneity was assessed by using Higgins' I2. Results: six studies with 691 HGSC patients were included. Adnexal CRS3 vs. CRS1-2 significantly stratified PFS, with a HR of 0.572 (0.447-0.733; p < 0.001). Omental CRS3 vs. CRS1-2 significantly stratified PFS with a similar HR (HR = 0.542; 95% CI 0.444-0.662; p < 0.001). Statistical heterogeneity was 0% in both analyses. Conclusions: adnexal CRS significantly stratifies PFS in HGSC and might be used when omental CRS is not assessable.
Lingua originaleEnglish
pagine (da-a)633-639
Numero di pagine7
RivistaDiagnostics
Volume12
DOI
Stato di pubblicazionePubblicato - 2022

Keywords

  • CRS
  • chemotherapy
  • high grade serous carcinoma
  • ovarian cancer
  • prognosis

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