Prognostic significance of tumor doubling time in mass-forming type cholangiocarcinoma.

Agostino Maria De Rose, Alessandro Cucchetti, Gennaro Clemente, Francesco Ardito, Ivo Giovannini, Giorgio Ercolani, Felice Giuliante, Antonio Daniele Pinna, Gennaro Nuzzo

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

13 Citazioni (Scopus)


Objective The aim of this study was to determine the prognostic significance of the preoperatively assessed tumor doubling time (DT) in patients undergoing liver resection for mass-forming intrahepatic cholangiocarcinoma (IHC). Methods We evaluated 79 patients who underwent curative resection for IHC, and in whom the same imaging technique was preoperatively available in two consecutive occasions, to allow the calculation of the DT. The influence of DT and other clinical and pathological variables on tumor recurrence and patient survival was determined by the Kaplan–Meier method and uni- and multivariate analysis. Results Median overall survival was 40 months; 1-, 3-, and 5-year survival rates were 86.1, 55.1, and 35.1 %, respectively. Median disease-free survival was 17 months; 1-, 3-, and 5-year disease-free survival rates were 62.0, 29.1, and 23.3 %, respectively. At univariate analysis, DT <70 days (p<0.001) and advanced tumor stage (p=0.024) were associated with worse overall survival and maintained significance at multivariate analysis. Conclusions DT is a clinically useful parameter to estimate the prognosis of “mass-forming” IHC in patients undergoing liver resection.
Lingua originaleEnglish
pagine (da-a)739-747
Numero di pagine9
RivistaJournal of Gastrointestinal Surgery
Stato di pubblicazionePubblicato - 2013


  • Intrahepatic cholangiocarcinoma
  • Liver resection
  • Prognosis
  • Tumor doubling time


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