Prognostic significance of the Ca2+ binding protein S100A2 in laryngeal squamous-cell carcinoma

L. Lauriola*, F. Michetti, N. Maggiano, Jacopo Galli, Gabriella Cadoni, B. Scḧafer, C. Heizmann, F. Ranelletti

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo

Abstract

: We investigated by immunocytochemistry the expression of the Ca(2+) binding protein S100A2 in 62 cases of laryngeal squamous-cell carcinoma (SCC). S100A2 was detected in 18/19 (95%) low-grade tumors and in 22/43 (51%) high-grade tumors, which were partially keratinizing. The remaining 21/43 (49%) high-grade tumors were non-keratinizing, anaplastic tumors and clearly S100A2-negative. In normal laryngeal squamous epithelium and in laryngeal SCC, S100A2 expression was strictly associated with that of cytokeratins 14 (P = 0.0002) and 17 (P = 0.0021), suggesting an association of S100A2 expression and cell commitment to squamous differentiation. A correlation was found between S100A2 tumor positivity and longer relapse-free (P = 0.0005) and overall (P = 0.0095) survival.
Lingua originaleInglese
pagine (da-a)345-349
Numero di pagine5
RivistaInternational Journal of Cancer
Volume89
Numero di pubblicazione4
DOI
Stato di pubblicazionePubblicato - 2000

All Science Journal Classification (ASJC) codes

  • Oncologia
  • Ricerca sul Cancro

Keywords

  • head and neck

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