TY - JOUR
T1 - Prognostic significance of the Ca2+ binding protein S100A2 in laryngeal squamous-cell carcinoma
AU - Lauriola, L.
AU - Michetti, F.
AU - Maggiano, N.
AU - Galli, Jacopo
AU - Cadoni, Gabriella
AU - Scḧafer, B.
AU - Heizmann, C.
AU - Ranelletti, F.
PY - 2000
Y1 - 2000
N2 - : We investigated by immunocytochemistry the expression of the Ca(2+) binding protein S100A2 in 62 cases of laryngeal squamous-cell carcinoma (SCC). S100A2 was detected in 18/19 (95%) low-grade tumors and in 22/43 (51%) high-grade tumors, which were partially keratinizing. The remaining 21/43 (49%) high-grade tumors were non-keratinizing, anaplastic tumors and clearly S100A2-negative. In normal laryngeal squamous epithelium and in laryngeal SCC, S100A2 expression was strictly associated with that of cytokeratins 14 (P = 0.0002) and 17 (P = 0.0021), suggesting an association of S100A2 expression and cell commitment to squamous differentiation. A correlation was found between S100A2 tumor positivity and longer relapse-free (P = 0.0005) and overall (P = 0.0095) survival.
AB - : We investigated by immunocytochemistry the expression of the Ca(2+) binding protein S100A2 in 62 cases of laryngeal squamous-cell carcinoma (SCC). S100A2 was detected in 18/19 (95%) low-grade tumors and in 22/43 (51%) high-grade tumors, which were partially keratinizing. The remaining 21/43 (49%) high-grade tumors were non-keratinizing, anaplastic tumors and clearly S100A2-negative. In normal laryngeal squamous epithelium and in laryngeal SCC, S100A2 expression was strictly associated with that of cytokeratins 14 (P = 0.0002) and 17 (P = 0.0021), suggesting an association of S100A2 expression and cell commitment to squamous differentiation. A correlation was found between S100A2 tumor positivity and longer relapse-free (P = 0.0005) and overall (P = 0.0095) survival.
KW - head and neck
KW - head and neck
UR - https://publicatt.unicatt.it/handle/10807/227582
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=0034691595&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0034691595&origin=inward
U2 - 10.1002/1097-0215(20000720)89:4<345::AID-IJC5>3.0.CO;2-T
DO - 10.1002/1097-0215(20000720)89:4<345::AID-IJC5>3.0.CO;2-T
M3 - Article
SN - 0020-7136
VL - 89
SP - 345
EP - 349
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 4
ER -